Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger

Taif Alholy; Walid Khaddam

Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger

Abstract

Magnesium oxide nanoparticles (MgO-NPs) were synthesis via green method using Opunita ficus indica extract as reducing and covering agent. The optimal formula for the preparation of MgO-NPs was determined by UV- Vis and DLS (Opunita ficus -indica extracted by distilled water and ethanol solvent, magnesium nitrate salt (1mM), stirred at 70 °C for 24 h with pH= 9). UV-Vis analysis showed a peak at 300 nm, while DLS measured the hydrodynamic diameter of the nanoparticles. FTIR results suggested that the polysaccharides, phenols and amines present in the extract might have been involved in the formation of MgO-NPs from Mg (NO3)2 as the reducing agent. Image J was utilized to analyze the SEM results and determine the size, which was on average 99 nm, the shape of the nanoparticles was spherical, and EDX spectrum confirmed the presence of magnesium (Mg). It was found that MgO-NPs are highly toxic against Aspergillus niger. Which showed a gradual inhibitory effect when using the concentration of 0.5% and 1.25%, and the inhibitory ability was 66.6%, 100% respectively, when using the poisoned food technique.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Microbiology

Journal Section

Research Article

Authors

Taif Alholy ^* This is me
Syria

Walid Khaddam This is me
0000-0001-6771-2211
Syria

Publication Date

June 28, 2025

Submission Date

December 21, 2022

Acceptance Date

January 28, 2023

Published in Issue

Year 2023 Volume: 27 Number: 3

IZ

https://izlik.org/JA23ZC95EG

Cite

RIS / Bibtex

APA

Alholy, T., & Khaddam, W. (2025). Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger. Journal of Research in Pharmacy, 27(3), 1188-1201. https://izlik.org/JA23ZC95EG

AMA

1.Alholy T, Khaddam W. Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger. J. Res. Pharm. 2025;27(3):1188-1201. https://izlik.org/JA23ZC95EG

Chicago

Alholy, Taif, and Walid Khaddam. 2025. “Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita Ficus-Indica and Their Antifungal Effect Against Aspergillus Niger”. Journal of Research in Pharmacy 27 (3): 1188-1201. https://izlik.org/JA23ZC95EG.

EndNote

Alholy T, Khaddam W (June 1, 2025) Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger. Journal of Research in Pharmacy 27 3 1188–1201.

IEEE

[1]T. Alholy and W. Khaddam, “Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger”, J. Res. Pharm., vol. 27, no. 3, pp. 1188–1201, June 2025, [Online]. Available: https://izlik.org/JA23ZC95EG

ISNAD

Alholy, Taif - Khaddam, Walid. “Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita Ficus-Indica and Their Antifungal Effect Against Aspergillus Niger”. Journal of Research in Pharmacy 27/3 (June 1, 2025): 1188-1201. https://izlik.org/JA23ZC95EG.

JAMA

1.Alholy T, Khaddam W. Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger. J. Res. Pharm. 2025;27:1188–1201.

MLA

Alholy, Taif, and Walid Khaddam. “Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita Ficus-Indica and Their Antifungal Effect Against Aspergillus Niger”. Journal of Research in Pharmacy, vol. 27, no. 3, June 2025, pp. 1188-01, https://izlik.org/JA23ZC95EG.

Vancouver

1.Taif Alholy, Walid Khaddam. Biosynthesis of Magnesium Oxide Nanoparticles Using Opunita ficus-indica and Their Antifungal Effect Against Aspergillus Niger. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(3):1188-201. Available from: https://izlik.org/JA23ZC95EG