Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration

Suresh Velayutham; Arunprasanth Sundararaju; Thamotharan Govindhaswamy; Muthukumaran Gurupackiyam; Anbukarasi Balakrishnan; Mohamed Yasar Abdul; Chetan Ashok; J Srikanth

Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration

Abstract

This study was designed to investigate the effect of ethanolic extract of Pedalium murex linnleaf (EEPML) in 3-Nitropropionic acid (3-NPA) induced neurodegeneration in a Sprague Dawley rat model. EEPML at a dose of 200 and 400mg/kg was given orally to desired group of animals for a period of 14 days. Neurodegeneration was induced by administering 3-Nitropropionic acid (10 mg/kg/i.p) on 14th day. Two hours after drug administration on 14th day of drug treatment, parameters such as in vitro anticholinesterase activity, DPPH Radical Scavenging Activity, behavioural test for memory and learning (Rotarod test, Open field test), Acetylcholine (ACh) content, Acetylcholinesterase (AChE) activity, Superoxide dismutase (SOD) level in brain homogenate were analysed. EEPML at both doses, i.e., 200 and 400 mg/kg, decreased the acetylcholinesterase in neurodegenerated rats. The EEPML 400 mg/kg/i.p had more pronounced effect on memory, learning test and motor coordination. The EEPML also decreased the body weight of neurodegenerated animals. Acetylcholine was found to be decreased in untreated neurodegenerated rats due to neuronal inflammation. The EEPML at both doses increased the acetylcholine level in neurodegenerated rats. Modulation of Acetylcholine level by the EEPML is related with its potential anti-oxidant and cholinesterase inhibitory activity.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Suresh Velayutham This is me
India

Arunprasanth Sundararaju This is me
India

Thamotharan Govindhaswamy This is me
India

Muthukumaran Gurupackiyam This is me
India

Anbukarasi Balakrishnan This is me
India

Mohamed Yasar Abdul This is me
India

Chetan Ashok This is me
India

J Srikanth ^*
India

Publication Date

June 28, 2025

Submission Date

November 12, 2022

Acceptance Date

March 3, 2023

Published in Issue

Year 2023 Volume: 27 Number: 3

IZ

https://izlik.org/JA73HT58TT

Cite

RIS / Bibtex

APA

Velayutham, S., Sundararaju, A., Govindhaswamy, T., Gurupackiyam, M., Balakrishnan, A., Abdul, M. Y., Ashok, C., & Srikanth, J. (2025). Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. Journal of Research in Pharmacy, 27(3), 1143-1156. https://izlik.org/JA73HT58TT

AMA

1.Velayutham S, Sundararaju A, Govindhaswamy T, et al. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. 2025;27(3):1143-1156. https://izlik.org/JA73HT58TT

Chicago

Velayutham, Suresh, Arunprasanth Sundararaju, Thamotharan Govindhaswamy, et al. 2025. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy 27 (3): 1143-56. https://izlik.org/JA73HT58TT.

EndNote

Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J (June 1, 2025) Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. Journal of Research in Pharmacy 27 3 1143–1156.

IEEE

[1]S. Velayutham et al., “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”, J. Res. Pharm., vol. 27, no. 3, pp. 1143–1156, June 2025, [Online]. Available: https://izlik.org/JA73HT58TT

ISNAD

Velayutham, Suresh - Sundararaju, Arunprasanth - Govindhaswamy, Thamotharan - Gurupackiyam, Muthukumaran - Balakrishnan, Anbukarasi - Abdul, Mohamed Yasar - Ashok, Chetan - Srikanth, J. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy 27/3 (June 1, 2025): 1143-1156. https://izlik.org/JA73HT58TT.

JAMA

1.Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. 2025;27:1143–1156.

MLA

Velayutham, Suresh, et al. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy, vol. 27, no. 3, June 2025, pp. 1143-56, https://izlik.org/JA73HT58TT.

Vancouver

1.Suresh Velayutham, Arunprasanth Sundararaju, Thamotharan Govindhaswamy, Muthukumaran Gurupackiyam, Anbukarasi Balakrishnan, Mohamed Yasar Abdul, Chetan Ashok, J Srikanth. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(3):1143-56. Available from: https://izlik.org/JA73HT58TT