The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial

Nasrin Moslemzadeh; Ali Özdemir; Mesut Sancar

doi:10.12991/jrespharm.1700641

The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial

Abstract

According to the World Health Organization, anemia is a prevalent public health issue in developing and industrialized nations, with serious consequences for individual health and broader social and economic development. Iron deficiency anemia (IDA), a prevalent global health issue in Türkiye, adversely affects multiple organs and physiological systems. This study aims to evaluate the impact of pharmacist-led educational interventions on improving patients' knowledge of the causes and consequences of IDA and on enhancing compliance with prescribed treatment regimens. This study was structured as a prospective, parallel, randomized controlled trial. It included all premenopausal women newly diagnosed with iron deficiency anemia (IDA) (hemoglobin levels below 12 g/dL) or those already undergoing iron therapy, who attended outpatient clinics at a research hospital in Istanbul, Türkiye. Participants were randomly allocated in a 1:1 ratio to either the intervention or control group using a computerized simple randomization program. A total of 116 patients were enrolled, with 56 assigned to the intervention group and 60 to the control group. Patients in the intervention group received verbal counseling on iron therapy and a brochure detailing the significance of anemia management, dietary adjustments, treatment recommendations, and strategies for managing side effects. Additionally, these patients were followed up weekly by a clinical pharmacist via telephone. In contrast, patients in the control group received standard medical care from their physicians without any pharmacist intervention. The mean age of the patients was 40.50 years. The majority of participants in the intervention group (78.3%) exhibited high compliance with iron deficiency anemia (IDA) supplements, compared to the control group (42.9%), with a statistically significant difference (p < 0.001). The mean increase in hemoglobin concentration in the intervention group (1.35 g/dL) was greater than that in the control group (0.70 g/dL) (p < 0.001). No serious or life-threatening adverse effects were reported in either group. This study demonstrated the importance of the clinical pharmacist's role in the treatment of iron deficiency anemia (IDA) in outpatient clinics; clinical pharmacist interventions and effective physician-pharmacist collaboration have led to improved disease management outcomes.

Keywords

References

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Details

Primary Language

English

Subjects

Clinical Pharmacy and Pharmacy Practice

Journal Section

Clinical Research

Authors

Nasrin Moslemzadeh
0009-0004-2493-5860
Türkiye

Ali Özdemir
0000-0002-8087-9654
Türkiye

Mesut Sancar ^*
0000-0002-7445-3235
Türkiye

Publication Date

March 15, 2026

Submission Date

May 16, 2025

Acceptance Date

July 5, 2025

Published in Issue

Year 2026 Volume: 30 Number: 2

DOI

https://doi.org/10.12991/jrespharm.1700641

IZ

https://izlik.org/JA67LL58EN

Cite

RIS / Bibtex

APA

Moslemzadeh, N., Özdemir, A., & Sancar, M. (2026). The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial. Journal of Research in Pharmacy, 30(2), 516-528. https://doi.org/10.12991/jrespharm.1700641

AMA

1.Moslemzadeh N, Özdemir A, Sancar M. The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial. J. Res. Pharm. 2026;30(2):516-528. doi:10.12991/jrespharm.1700641

Chicago

Moslemzadeh, Nasrin, Ali Özdemir, and Mesut Sancar. 2026. “The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients With Iron Deficiency Anemia: A Randomized Controlled Trial”. Journal of Research in Pharmacy 30 (2): 516-28. https://doi.org/10.12991/jrespharm.1700641.

EndNote

Moslemzadeh N, Özdemir A, Sancar M (March 1, 2026) The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial. Journal of Research in Pharmacy 30 2 516–528.

IEEE

[1]N. Moslemzadeh, A. Özdemir, and M. Sancar, “The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial”, J. Res. Pharm., vol. 30, no. 2, pp. 516–528, Mar. 2026, doi: 10.12991/jrespharm.1700641.

ISNAD

Moslemzadeh, Nasrin - Özdemir, Ali - Sancar, Mesut. “The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients With Iron Deficiency Anemia: A Randomized Controlled Trial”. Journal of Research in Pharmacy 30/2 (March 1, 2026): 516-528. https://doi.org/10.12991/jrespharm.1700641.

JAMA

1.Moslemzadeh N, Özdemir A, Sancar M. The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial. J. Res. Pharm. 2026;30:516–528.

MLA

Moslemzadeh, Nasrin, et al. “The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients With Iron Deficiency Anemia: A Randomized Controlled Trial”. Journal of Research in Pharmacy, vol. 30, no. 2, Mar. 2026, pp. 516-28, doi:10.12991/jrespharm.1700641.

Vancouver

1.Nasrin Moslemzadeh, Ali Özdemir, Mesut Sancar. The Effect of Patient Education Provided by Clinical Pharmacists in Premenopausal Female Patients with Iron Deficiency Anemia: A Randomized Controlled Trial. J. Res. Pharm. 2026 Mar. 1;30(2):516-28. doi:10.12991/jrespharm.1700641