DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH

Miloš N. Milosavljević; Jovana Milosavljević; Ana V. Pejčić; Petar Arsenijević; Ivana živanović Mačužić; Nevena Folić; Slobodan Janković

DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH

Abstract

We designed our research as an ambidirectional cohort study that was conducted on the population of pregnant women whose pregnancy was monitored at the Clinic for Gynecology and Obstetrics of the University Clinical Centre Kragujevac, Serbia. All pregnant women with pregnancies confirmed by a gynecology specialist were taken into account, with the exception of pregnant women under the age of 18, functionally illiterate pregnant women and those with a confirmed high risk of genetic abnormalities of the fetus by a combination of ultrasound and biochemical examination during the 12th week of pregnancy. Our major outcome measures were body weight, body length and head circumference of newborns at birth. We examined the potential impact of the following variables to the newborn body size: demographic factors, presence of acute or chronic diseases during pregnancy, medications used during pregnancy, pregnancy factors, presence of uterine or placental abnormalities and maternal nutrition. For the assessment of the nutritional status of pregnant women, we previously developed and validated a special questionnaire that we named Balkan Food Quality and Diversity in Pregnancy Questionnaire-18 (BFQDPQ-18) [6]. We used the method of multiple linear regression analysis to evaluate the influence of potential factors on birth weight, length, and head circumference.

Keywords

References

[1] Kheirouri S, Alizadeh M. Impact of prenatal maternal factors and birth order on the anthropometric status of newborns in Iran. J Biosoc Sci. 2017; 49(2): 251-264. [CrossRef]
[2] Zeljkovic A, Vekic J, Spasic S, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V, Gojkovic T, Ardalic D, Mandic-Markovic V, Cerovic N, Mikovic Z. Changes in LDL and HDL subclasses in normal pregnancy and associations with birth weight, birth length and head circumference. Matern Child Health J. 2013; 17(3): 556-565. [CrossRef]
[3] Lunde A, Melve KK, Gjessing HK, Skjaerven R, Irgens LM. Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol. 2007; 165(7): 734-741. [CrossRef]
[4] Parazzini F, Benedetto C, Bortolus R. Nifedipine versus expectant management in mild to moderate hypertension in pregnancy. Br J Obstet Gynaecol. 1998; 105(7): 718–722. [CrossRef]
[5] Karahanoglu E, Altinboga O, Akpinar F, Demirdag E, Ozdemirci S, Akyol A, Yalvac S. Nifedipine increases fetoplacental perfusion. J Perinat Med. 2017; 45(1): 51-55. [CrossRef]
[6] Milosavljević J, Pejčić A, Arsenijević P, Dimitrijević A, Milosavljević M, Mihajlović D, Janković S. Testing of new instrument for measuring quality and diversity of nutrition in pregnancy. Ginekol Pol. 2023; 94(1): 73-78. [CrossRef]
[7] Kemp MW, Newnham JP, Challis JG, Jobe AH, Stock SJ. The clinical use of corticosteroids in pregnancy. Hum Reprod Update. 2016; 22(2): 240-259. [CrossRef]
[8] Crowther CA, McKinlay CJ, Middleton P, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database Syst Rev. 2015; 2015(7): CD003935. [CrossRef]

[9] Rodriguez A, Wang Y, Ali Khan A, Cartwright R, Gissler M, Järvelin MR. Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish Medical Birth Register. PLoS Med. 2019; 16(2): e1002746. [CrossRef]
[10] Thorp JA, Jones PG, Knox E, Clark RH. Does antenatal corticosteroid therapy affect birth weight and head circumference? Obstet Gynecol. 2002; 99(1): 101-108. [CrossRef]
[11] Brown CM, Garovic VD. Drug treatment of hypertension in pregnancy. Drugs. 2014; 74(3): 283-296. [CrossRef]
[12] Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, Militello M, Pedata R. Hypertensive disorders of pregnancy. J Prenat Med. 2009; 3(1): 1-5.
[13] Butalia S, Audibert F, Côté AM, Firoz T, Logan AG, Magee LA, Mundle W, Rey E, Rabi DM, Daskalopoulou SS, Nerenberg KA; Hypertension Canada. Hypertension Canada's 2018 Guidelines for the Management of Hypertension in Pregnancy. Can J Cardiol. 2018; 34(5): 526-531. [CrossRef]
[14] Hoeltzenbein M, Beck E, Fietz AK, Wernicke J, Zinke S, Kayser A, Padberg S, Weber-Schoendorfer C, Meister R, Schaefer C. Pregnancy outcome after first trimester use of methyldopa: A prospective cohort study. Hypertension. 2017; 70(1): 201-208. [CrossRef]
[15] Orbach H, Matok I, Gorodischer R, Sheiner E, Daniel S, Wiznitzer A, Koren G, Levy A. Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes. Am J Obstet Gynecol. 2013; 208(4): 301.e1-6. [CrossRef]
[16] Harbison AF, Polly DM, Musselman ME. Antiinfective therapy for pregnant or lactating patients in the emergency department. Am J Health Syst Pharm. 2015; 72(3): 189-197. [CrossRef]
[17] Lamont HF, Blogg HJ, Lamont RF. Safety of antimicrobial treatment during pregnancy: A current review of resistance, immunomodulation and teratogenicity. Expert Opin Drug Saf. 2014; 13(12): 1569-1581. [CrossRef]
[18] Jepsen P, Skriver MV, Floyd A, Lipworth L, Schønheyder HC, Sørensen HT. A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark. Br J Clin Pharmacol. 2003; 55(2): 216-221. [CrossRef]
[19] Czeizel AE, Rockenbauer M, Olsen J. Use of antibiotics during pregnancy. Eur J Obstet Gynecol Reprod Biol. 1998; 81(1): 1-8. [CrossRef]
[20] Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, Neelon SE, Fuemmeler B, Iversen E, Wang F, Kurtzberg J, Jirtle RL, Hoyo C. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond). 2013; 37(7): 907- 913. [CrossRef]
[21] Mueller NT, Rifas-Shiman SL, Blaser MJ, Gillman MW, Hivert MF. Association of prenatal antibiotics with foetal size and cord blood leptin and adiponectin. Pediatr Obes. 2017; 12(2): 129-136. [CrossRef]

Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Conference Paper

Authors

Miloš N. Milosavljević ^*
0000-0002-1786-1507
Serbia

Jovana Milosavljević This is me
0000-0001-9660-6709
Serbia

Ana V. Pejčić
0000-0003-1741-0025
Serbia

Petar Arsenijević This is me
0000-0001-8267-7717
Serbia

Ivana živanović Mačužić This is me
0000-0001-6860-7237
Serbia

Nevena Folić This is me
0000-0001-9494-881X
Serbia

Slobodan Janković This is me
0000-0002-1519-8828
Serbia

Publication Date

June 28, 2025

Submission Date

April 19, 2023

Acceptance Date

May 3, 2023

Published in Issue

Year 2023 Volume: 27 Number: Current Research Topıcs In Pharmacy: Pharmacology Debates

IZ

https://izlik.org/JA27YM72LD

Cite

RIS / Bibtex

APA

Milosavljević, M. N., Milosavljević, J., Pejčić, A. V., Arsenijević, P., živanović Mačužić, I., Folić, N., & Janković, S. (2025). DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH. Journal of Research in Pharmacy, 27(Current Research Topıcs In Pharmacy: Pharmacology Debates), 10-14. https://izlik.org/JA27YM72LD

AMA

1.Milosavljević MN, Milosavljević J, Pejčić AV, et al. DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH. J. Res. Pharm. 2025;27(Current Research Topıcs In Pharmacy: Pharmacology Debates):10-14. https://izlik.org/JA27YM72LD

Chicago

Milosavljević, Miloš N., Jovana Milosavljević, Ana V. Pejčić, et al. 2025. “DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH”. Journal of Research in Pharmacy 27 (Current Research Topıcs In Pharmacy: Pharmacology Debates): 10-14. https://izlik.org/JA27YM72LD.

EndNote

Milosavljević MN, Milosavljević J, Pejčić AV, Arsenijević P, živanović Mačužić I, Folić N, Janković S (July 1, 2025) DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH. Journal of Research in Pharmacy 27 Current Research Topıcs In Pharmacy: Pharmacology Debates 10–14.

IEEE

[1]M. N. Milosavljević et al., “DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH”, J. Res. Pharm., vol. 27, no. Current Research Topıcs In Pharmacy: Pharmacology Debates, pp. 10–14, July 2025, [Online]. Available: https://izlik.org/JA27YM72LD

ISNAD

Milosavljević, Miloš N. - Milosavljević, Jovana - Pejčić, Ana V. - Arsenijević, Petar - živanović Mačužić, Ivana - Folić, Nevena - Janković, Slobodan. “DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH”. Journal of Research in Pharmacy 27/Current Research Topıcs In Pharmacy: Pharmacology Debates (July 1, 2025): 10-14. https://izlik.org/JA27YM72LD.

JAMA

1.Milosavljević MN, Milosavljević J, Pejčić AV, Arsenijević P, živanović Mačužić I, Folić N, Janković S. DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH. J. Res. Pharm. 2025;27:10–14.

MLA

Milosavljević, Miloš N., et al. “DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH”. Journal of Research in Pharmacy, vol. 27, no. Current Research Topıcs In Pharmacy: Pharmacology Debates, July 2025, pp. 10-14, https://izlik.org/JA27YM72LD.

Vancouver

1.Miloš N. Milosavljević, Jovana Milosavljević, Ana V. Pejčić, Petar Arsenijević, Ivana živanović Mačužić, Nevena Folić, Slobodan Janković. DRUGS AFFECTING NEWBORN WEIGHT, LENGTH AND HEAD CIRCUMFERENCE AT BIRTH. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(Current Research Topıcs In Pharmacy: Pharmacology Debates):10-4. Available from: https://izlik.org/JA27YM72LD