Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil

Rima Konya Konuk; Gülşah Esen; Yağmur Özhan; Betül Demirci; Hande Sipahi; Muhammed Hamitoğlu; Etil Güzelmeriç

doi:10.12991/jrespharm.1782830

Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil

Abstract

Tanacetum parthenium (L.) Sch.Bip., a well-known member of the Asteraceae family, has long been used in traditional medicine against different ailments. Although the biological activities of its extracts and constituents such as parthenolide have been extensively studied, investigations on its essential oil remain limited. This study aimed to investigate the chemical composition and in vitro biological activities of essential oil obtained from T. parthenium wild-growing in Türkiye. The essential oil was obtained via steam distillation and analyzed by GC-FID and GC-MS. Its anti-inflammatory potential was evaluated by measuring nitric oxide (NO) inhibition in LPS-stimulated RAW 264.7 macrophages using the Griess assay. In addition, the cytotoxic effects of the essential oil were assessed on two human breast cancer cell lines (MCF-7 and MDA-MB-231) using the MTT assay. The results showed that the essential oil reduced NO production by 27% and 11% with 0.5 and 1 mg/mL, and exhibited weak cytotoxicity with IC₅₀ values of 333 ± 2.5 µg/mL and 214 ± 13.8 µg/mL against MCF-7 and MDA-MB-231, respectively. These findings highlight the potential of T. parthenium essential oil as a natural source of bioactive compounds with anti-inflammatory and anticancer properties, warranting further pharmacological and phytochemical investigations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Rima Konya Konuk ^*
0000-0001-6228-4369
Türkiye

Gülşah Esen
0009-0002-8326-5911
Türkiye

Yağmur Özhan
0000-0001-6173-3281
Türkiye

Betül Demirci
0000-0003-2343-746X
Türkiye

Hande Sipahi
0000-0001-6482-3143
Türkiye

Muhammed Hamitoğlu
0000-0002-4545-0756
Türkiye

Etil Güzelmeriç
0000-0001-9696-3271
Türkiye

Publication Date

October 6, 2026

Submission Date

September 12, 2025

Acceptance Date

July 3, 2026

Published in Issue

Year 2026 Volume: 30 Number: 5

DOI

https://doi.org/10.12991/jrespharm.1782830

IZ

https://izlik.org/JA72RB39PF

Cite

RIS / Bibtex

APA

Konya Konuk, R., Esen, G., Özhan, Y., Demirci, B., Sipahi, H., Hamitoğlu, M., & Güzelmeriç, E. (2026). Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil. Journal of Research in Pharmacy, 30(5), 1203-1212. https://doi.org/10.12991/jrespharm.1782830

AMA

1.Konya Konuk R, Esen G, Özhan Y, et al. Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil. J. Res. Pharm. 2026;30(5):1203-1212. doi:10.12991/jrespharm.1782830

Chicago

Konya Konuk, Rima, Gülşah Esen, Yağmur Özhan, et al. 2026. “Anti-Inflammatory and Cytotoxic Activities of Tanacetum Parthenium Essential Oil”. Journal of Research in Pharmacy 30 (5): 1203-12. https://doi.org/10.12991/jrespharm.1782830.

EndNote

Konya Konuk R, Esen G, Özhan Y, Demirci B, Sipahi H, Hamitoğlu M, Güzelmeriç E (October 1, 2026) Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil. Journal of Research in Pharmacy 30 5 1203–1212.

IEEE

[1]R. Konya Konuk et al., “Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil”, J. Res. Pharm., vol. 30, no. 5, pp. 1203–1212, Oct. 2026, doi: 10.12991/jrespharm.1782830.

ISNAD

Konya Konuk, Rima - Esen, Gülşah - Özhan, Yağmur - Demirci, Betül - Sipahi, Hande - Hamitoğlu, Muhammed - Güzelmeriç, Etil. “Anti-Inflammatory and Cytotoxic Activities of Tanacetum Parthenium Essential Oil”. Journal of Research in Pharmacy 30/5 (October 1, 2026): 1203-1212. https://doi.org/10.12991/jrespharm.1782830.

JAMA

1.Konya Konuk R, Esen G, Özhan Y, Demirci B, Sipahi H, Hamitoğlu M, Güzelmeriç E. Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil. J. Res. Pharm. 2026;30:1203–1212.

MLA

Konya Konuk, Rima, et al. “Anti-Inflammatory and Cytotoxic Activities of Tanacetum Parthenium Essential Oil”. Journal of Research in Pharmacy, vol. 30, no. 5, Oct. 2026, pp. 1203-12, doi:10.12991/jrespharm.1782830.

Vancouver

1.Rima Konya Konuk, Gülşah Esen, Yağmur Özhan, Betül Demirci, Hande Sipahi, Muhammed Hamitoğlu, Etil Güzelmeriç. Anti-inflammatory and cytotoxic activities of Tanacetum parthenium essential oil. J. Res. Pharm. 2026 Oct. 1;30(5):1203-12. doi:10.12991/jrespharm.1782830