Development of nanoemulgel formula with purified Anredera cordifolia (Ten.) Steenis leaves extract for antiinflammatory activity

Year 2025, Volume: 29 Issue: 6, 2239 - 2252, 02.11.2025

Desak Made Nita Pratiwi Sri Hartati Yuliani , Putu Oka Samirana

https://doi.org/10.12991/jrespharm.1796226

Abstract

This study evaluates the potential of a nanoemulgel formulation of purified extract from Anredera cordifolia (Ten.) Steenis leaves, which is rich in flavonoids, as a substance that reduces inflammation. The aim of this study is to evaluate the effects of concentrations of Tween 80 and PEG 400 on the physicochemical characteristics and antiinflammatory activities of nanoemulgel. Four nanoemulsion formulas (formula 1, formula A, formula B, and formula AB), which vary in the concentrations of Tween 80 and PEG 400, were tested for their characteristics and have met all the requirements for nanoemulsion characteristics by assessing percent transmittance, particle size, zeta potential and PDI value. Formula AB indicates the smallest particle size (84.233 ± 3.513 nm) and the highest transmittance percentage (99.367 ± 0.306%). The interaction of Tween 80 and PEG 400 affects the pH response, spreading ability, adhesion, and viscosity. Formula 1, formula A, formula B, and formula AB can be accepted or are within the optimal area. The antiinflammatory test using the carrageenan model showed that formula A and formula AB had the best anti-inflammatory activity compared to the other formulas, approaching the activity of the positive control (betamethasone cream). Based on the assessment of edema volume, the anti-inflammatory activity was assessed, and formulae A and AB demonstrated a considerable inhibition of inflammation at the 4th, 5th, and 6th hour. The study's findings suggest that the purified extract from Anredera cordifolia (Ten.) Steenis leaf nanoemulgel has promising anti-inflammatory properties and is useful for topical application.

Keywords

Anredera cordifolia , flavonoids , purified extracts , nanoemulgel , anti-inflammatory

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