Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems

Karan Lokhande; Dhanashree P. Sanap; Kisan Jadhav

doi:10.12991/jrespharm.1798376

Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems

Abstract

The present study aimed to develop a novel drug delivery system utilizing microemulsion as an alternative to traditional oral formulations. This system sought to enhance dissolution rate and thereby improve bioavailability while circumventing first-pass metabolism. To formulate the delivery system, oil was chosen based on drug solubility, while surfactants and co-surfactants (Smix) were selected based on their ability to solubilize the oil and efficiently create microemulsion. The existence ranges of microemulsions were determined through pseudo-ternary phase diagrams, and multiple formulations were developed. The influence of Smix ratio on microemulsion formation and in vitro permeation through a cellophane membrane was investigated. The optimized microemulsion formulations, A7(w/o) and B2(o/w), exhibited globule sizes of 176 nm and 237 nm respectively, with polydispersity indices of 0.02 and 0.14. Additionally, they demonstrated pH values of 5.24 and 5.98, viscosities of 0.809 cp and 0.810 cp, zeta potentials of -30 and 33 mV and conductance values of 47 μS/cm and 166 μS/cm. In vitro drug release for A7 and B2 batches exhibited 71% and 99.5% release respectively. These findings suggested that the developed B2 batch microemulsion holds promise as an alternative for Ondansetron therapy, particularly in mitigating nausea and vomiting induced by cancer medications or radiation therapy.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Karan Lokhande
0009-0007-4079-5935
India

Dhanashree P. Sanap ^*
0000-0002-4794-7598
India

Kisan Jadhav This is me
0000-0001-7563-3935
India

Publication Date

November 2, 2025

Submission Date

May 31, 2024

Acceptance Date

November 19, 2024

Published in Issue

Year 2025 Volume: 29 Number: 6

DOI

https://doi.org/10.12991/jrespharm.1798376

IZ

https://izlik.org/JA96XP56GS

Cite

RIS / Bibtex

APA

Lokhande, K., Sanap, D. P., & Jadhav, K. (2025). Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems. Journal of Research in Pharmacy, 29(6), 2574-2586. https://doi.org/10.12991/jrespharm.1798376

AMA

1.Lokhande K, Sanap DP, Jadhav K. Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems. J. Res. Pharm. 2025;29(6):2574-2586. doi:10.12991/jrespharm.1798376

Chicago

Lokhande, Karan, Dhanashree P. Sanap, and Kisan Jadhav. 2025. “Enhanced Delivery of Ondansetron: Formulation, Development, and Evaluation of Microemulsion Systems”. Journal of Research in Pharmacy 29 (6): 2574-86. https://doi.org/10.12991/jrespharm.1798376.

EndNote

Lokhande K, Sanap DP, Jadhav K (November 1, 2025) Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems. Journal of Research in Pharmacy 29 6 2574–2586.

IEEE

[1]K. Lokhande, D. P. Sanap, and K. Jadhav, “Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems”, J. Res. Pharm., vol. 29, no. 6, pp. 2574–2586, Nov. 2025, doi: 10.12991/jrespharm.1798376.

ISNAD

Lokhande, Karan - Sanap, Dhanashree P. - Jadhav, Kisan. “Enhanced Delivery of Ondansetron: Formulation, Development, and Evaluation of Microemulsion Systems”. Journal of Research in Pharmacy 29/6 (November 1, 2025): 2574-2586. https://doi.org/10.12991/jrespharm.1798376.

JAMA

1.Lokhande K, Sanap DP, Jadhav K. Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems. J. Res. Pharm. 2025;29:2574–2586.

MLA

Lokhande, Karan, et al. “Enhanced Delivery of Ondansetron: Formulation, Development, and Evaluation of Microemulsion Systems”. Journal of Research in Pharmacy, vol. 29, no. 6, Nov. 2025, pp. 2574-86, doi:10.12991/jrespharm.1798376.

Vancouver

1.Karan Lokhande, Dhanashree P. Sanap, Kisan Jadhav. Enhanced delivery of ondansetron: Formulation, development, and evaluation of microemulsion systems. J. Res. Pharm. 2025 Nov. 1;29(6):2574-86. doi:10.12991/jrespharm.1798376