In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging

Year 2026, Volume: 30 Issue: 2, 569 - 575, 15.03.2026

Hussein Alkufi , Hanan J. Kassab

https://doi.org/10.12991/jrespharm.1909321

https://izlik.org/JA79AE45SE

Abstract

This study investigated the efficacy of nasal injection of rhodamine B nanospanlastic (RBN) for magnetic vesicle imaging of specific brain locations. Effective delivery of RBN, which functions as fluorescence agents, to specific brain regions is necessary to achieve fluorescence particle imaging (FPI). There has been interest in nasal administration as a means of administering drugs directly to the brain, thereby circumventing the blood-brain barrier. We offered experimental nasal fluorescence agent administration by in vivo research. Fluorescent tests confirmed that, upon nasal delivery, the intended nanospanlastic migrated into the brain. Furthermore, using fluorescent microscopy, we demonstrated how these nanospanlastics accumulate in specific target regions. It was shown in the study that delivering fluorescent nanospanlastic through the nose to the brains of rats worked. The field of fluorescent particle imaging in certain brain regions should significantly progress as a result of the findings of this study.

Keywords

Fluorescent nanospanlastic , nasal to brain delivery , florescent particle imaging , Rhodamine B.

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