In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging

Hussein Alkufi; Hanan J. Kassab

doi:10.12991/jrespharm.1909321

In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging

Abstract

This study investigated the efficacy of nasal injection of rhodamine B nanospanlastic (RBN) for magnetic vesicle imaging of specific brain locations. Effective delivery of RBN, which functions as fluorescence agents, to specific brain regions is necessary to achieve fluorescence particle imaging (FPI). There has been interest in nasal administration as a means of administering drugs directly to the brain, thereby circumventing the blood-brain barrier. We offered experimental nasal fluorescence agent administration by in vivo research. Fluorescent tests confirmed that, upon nasal delivery, the intended nanospanlastic migrated into the brain. Furthermore, using fluorescent microscopy, we demonstrated how these nanospanlastics accumulate in specific target regions. It was shown in the study that delivering fluorescent nanospanlastic through the nose to the brains of rats worked. The field of fluorescent particle imaging in certain brain regions should significantly progress as a result of the findings of this study.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Hussein Alkufi
0000-0001-6977-6737
Iraq

Hanan J. Kassab ^* This is me
0000-0001-9590-339X
Iraq

Publication Date

March 15, 2026

Submission Date

October 26, 2024

Acceptance Date

January 31, 2025

Published in Issue

Year 2026 Volume: 30 Number: 2

DOI

https://doi.org/10.12991/jrespharm.1909321

IZ

https://izlik.org/JA79AE45SE

Cite

RIS / Bibtex

APA

Alkufi, H., & J. Kassab, H. (2026). In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging. Journal of Research in Pharmacy, 30(2), 569-575. https://doi.org/10.12991/jrespharm.1909321

AMA

1.Alkufi H, J. Kassab H. In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging. J. Res. Pharm. 2026;30(2):569-575. doi:10.12991/jrespharm.1909321

Chicago

Alkufi, Hussein, and Hanan J. Kassab. 2026. “In-Vivo Examination of Nasal-to-Brain Administration for Delivering Rhodamine B Nanospanlastic for Fluorescent Vesicle Imaging”. Journal of Research in Pharmacy 30 (2): 569-75. https://doi.org/10.12991/jrespharm.1909321.

EndNote

Alkufi H, J. Kassab H (March 1, 2026) In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging. Journal of Research in Pharmacy 30 2 569–575.

IEEE

[1]H. Alkufi and H. J. Kassab, “In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging”, J. Res. Pharm., vol. 30, no. 2, pp. 569–575, Mar. 2026, doi: 10.12991/jrespharm.1909321.

ISNAD

Alkufi, Hussein - J. Kassab, Hanan. “In-Vivo Examination of Nasal-to-Brain Administration for Delivering Rhodamine B Nanospanlastic for Fluorescent Vesicle Imaging”. Journal of Research in Pharmacy 30/2 (March 1, 2026): 569-575. https://doi.org/10.12991/jrespharm.1909321.

JAMA

1.Alkufi H, J. Kassab H. In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging. J. Res. Pharm. 2026;30:569–575.

MLA

Alkufi, Hussein, and Hanan J. Kassab. “In-Vivo Examination of Nasal-to-Brain Administration for Delivering Rhodamine B Nanospanlastic for Fluorescent Vesicle Imaging”. Journal of Research in Pharmacy, vol. 30, no. 2, Mar. 2026, pp. 569-75, doi:10.12991/jrespharm.1909321.

Vancouver

1.Hussein Alkufi, Hanan J. Kassab. In-vivo examination of nasal-to-brain administration for delivering rhodamine B nanospanlastic for fluorescent vesicle imaging. J. Res. Pharm. 2026 Mar. 1;30(2):569-75. doi:10.12991/jrespharm.1909321