The impact of carvedilol on level of interleukin-6, superoxide dismutase, elastin levels and epidermal thickness in experimentally aging induced mice model

Year 2025, Volume: 29 Issue: 1, 11 - 19

Elaf Mahmood Shihab Haitham Mahmood Kadhim Samer Salim Shahooth

Abstract

The study aimed to evaluate the antiaging activity of carvedilol, as it has antioxidant and anti inflammatory activity, and also to investigate whether it’s better to give carvedilol with or after aging. The study was conducted on six groups (I-VI) of male mice, ‎each consisting of 10 animals who were administered, for 6 weeks, oral normal saline only, 500 mg/kg of D-galactose (induction model), d-galactose 500 mg/kg, and vitamin C 100 mg/kg concomitantly, D-galactose 500 mg/kg followed by vitamin C 100 mg/kg; D-galactose 500 mg/kg; and carvedilol 10 mg/kg concomitantly; and galactose 500 mg/kg followed by carvedilol 10 mg/kg; respectively. Animals were killed, and heart tissue was taken and homogenized for the measurement of interleukin-6 and superoxide dismutase by ELISA technique, while skin tissue was divided into two parts, one homogenized to determine elastin level and another for histopathological analysis to determine epidermal thickness. Findings showed a significant drop in the level of interleukin-6 with a substantial elevation in Superoxide dismutase (SOD) and elastin level, along with an improvement in the epidermal thickness in both carvedilol treated groups, which revealed that carvedilol may have an anti-aging effect by decreasing oxidative stress, restoring normal levels of inflammatory markers, and postponing the aging of the skin, which is obtained when the carvedilol is used with or after the aging induction, with superiority when used at the beginning of the process.

Keywords

Carvedilol, elastin, epidermal thickness, interleukin-6, superoxide ismutase

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