Fiber and starch of Colocasia esculenta var. Mentawai ameliorate adiposity, dyslipidemia and gut dysbiosis in mice fed high fat diet

Year 2025, Volume: 29 Issue: 1, 310 - 321

Putra Santoso , Resti Rahayu , Wardatul Aini Salsabila Dhiah Hirwanto Syafruddin Ilyas

Abstract

Mentawai taro (Colocasia esculenta var. Mentawai, Araceae) corm is a staple food for local people in
Mentawai islands, West Sumatra, Indonesia. This study aimed to determine whether the incorporation of fiber and
starch extracted from Mentawai taro corm could improve adiposity and plasma lipid profiles and intestinal microbiota
composition in mice fed a fatty diet. Adult male mice (n = 24) were assigned to four groups of diet treatments: normal
diet (ND), high-fat diet (HFD), and HFD supplemented with 20% of fiber or starch from Mentawai taro corm,
respectively. After 12-week treatment, body weight, adipose tissues, plasma lipid profiles and intestinal microbiota
composition were investigated. The results showed that the incorporation of fiber and starch of Mentawai taro corm was
capable of substantially preventing the excessive body weight increase against HFD. Moreover, fiber and starch could
significantly suppress the increase of white adipose tissue mass and adipocyte hypertrophy while preventing the
reduction of brown adipose tissue mass and adipocyte hypertrophy. The fiber and starch also could effectively reduce
total plasma cholesterol, low-density lipoprotein-cholesterol, and triglyceride levels. The result also indicated that the
fiber and starch of Mentawai taro corm could modulate the diversity of intestinal microbiota by promoting the health
beneficial taxa while suppressing the pathogenic taxa. Overall, the fiber effectivity in managing the detrimental effects of
fatty diet outperformed the starch of Mentawai taro corm. Hence, it could be recommended as a potent supplement to
combat diet-induced metabolic problems, particularly obesity, dyslipidemia, and gut dysbiosis.

Keywords

adipose tissue, Colocasia esculenta, gut dysbiosis, high-fat diet, plasma lipids, staple food

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