Proof-of-concept about the role of dietary agents in the inhibition and prevention of carcinogenesis and metastasis: Focus on animal model studies

Year 2025, Volume: 29 Issue: 1, 436 - 444

Mirna Azalea Romero Uteuliyev Yerzhan Sabitaliyevich Moldagassimova Aizat Ospanova Zhanar

Abstract

The field of nutrigenomics has gained considerable limelight and interdisciplinary researchers have started
to realize its significance as a goldmine for the discovery of pathways that are important as dietary targets. Emerging
evidence has provided wealth of exciting proof-of-concept studies highlighting an important role in the elucidation of
oncogenic signaling cascades that can be pharmacologically targeted by dietary agents, whole extracts and isolated
compounds for the inhibition/prevention of carcinogenesis and metastasis. In this review, we have critically analyzed
some of the mechanistic animal models studies which have rationally propelled the field in a frontward direction. We
also provide an overview of the fruits-mediated anti-metastatic effects in metastasis models that highlight how
nutrigenomics may be combined with pharmacological therapies for synergistic effects, potentially ushering a path
towards precision nutrition for cancer.

Keywords

Cancer, Nutrigenomics, Metastasis, Cell signaling, Apoptosis

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