Synthesis and characterization of gum acacia stabilized zinc oxide / titanium dioxide nanoparticles embedded with Entacapone for in vitro drug release

Year 2025, Volume: 29 Issue: 1, 384 - 395

Seema Firdouse

Abstract

Nanotechnology is among the most developing aspects of the medical stream. Gum acacia (GA), being
biocompatible, naturally occurring, non-toxic, and inexpensive polymer, has gained tremendous attention in the field of
pharmacy. The nanoparticle production using Gum acacia as a template led to more stable drug delivery systems. Zinc
oxide (ZnO) and Titanium dioxide (TiO2) possess potential biological applications including anticancer activity,
antimicrobial activity, bioimaging, and potent drug carrier properties. The synthesis of Gum acacia stabilized Zinc oxide
and Titanium dioxide nanoparticles incorporated with Entacapone an antiparkinsonian drug, was carried out keeping in
view all these aspects. Entacapone is a combination of drug therapy with levodopa and carbidopa in the treatment of
Parkinson’s disease (a neuro-degenerative disorder). The synthesized drug – nanocomposite showed extended release or
sustained-release properties. According to the experimental results, it is reported that the Gum acacia along with ZnO
and TiO2 acts as a drug delivery carrier releasing Entacapone at the intended site in desired time and quantity.

Keywords

Nanoparticles, Drug delivery carrier, Sustained release, Entacapone, Anti-parkinsonian drug

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