Cytotoxic evaluation of some plants against renal cancer cell lines

Year 2025, Volume: 29 Issue: 2, 585 - 589

Feyyaz Mihoğlugil Demet Akalgan Aklar Fatma Tosun

https://doi.org/10.12991/jrespharm.1661047

Abstract

In the current study, we evaluated the cytotoxic activities of 21 extracts from 7 plants belonging to 4 families. The dichloromethane, ethyl acetate, and methanol extracts of the plants were screened for their cytotoxic activities on the renal (A498 and U031) cancer cell lines. 8 extracts exhibited more than 50% growth inhibition at a 25 ug/mL concentration on both renal cancer A498 and UO31 cell lines. The highest cytotoxic activity on the renal cancer UO31 cell line was observed for the methanol extract of the aerial parts of Telekia speciosa with 66% inhibition at a 25 ug/mL concentration. The highest cytotoxic activity on the renal cancer A498 cell line was found for the dichloromethane extract of the aerial parts of Coronilla varia with 64% inhibition at a 25 ug/mL concentration.

Keywords

Cytotoxic activity, renal cancer, Telekia speciosa, Coronilla varia

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