A comprehensive review on triazoles as anticancer agents

Year 2025, Volume: 29 Issue: 2, 639 - 666

Lala Ahmadova Merve Camci Eren Özlen Güzel Akdemir

https://doi.org/10.12991/jrespharm.1664884

Abstract

Despite the advancements in anticancer drug design, new pharmacological compounds that are safer, more effective, and able to stop the emergence of resistance to themselves are still desperately needed. Triazoles have a broad range of biological activities, including anticancer, antiviral, and antibacterial activities. Also, they can interact with diverse enzyme systems via hydrogen bonds, electrostatic interactions, and other mechanisms. Due to these advantages, triazoles have become one of the most popular scaffolds in medicinal chemistry and have attracted researchers' attention. In this review, a comprehensive overview of recent advances in anticancer triazoles, focusing on developments within the last five years, their classification based on their mode of action and synthesis methodology, and a summary of historical progress in synthesis techniques are provided to offer researchers a broad perspective.

Keywords

triazole, anticancer, synthesis, activity, molecular modelling

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