The effect of calcium supplements on troponin variables in athletes and their association with bone diseases : Implications for myocardial health

Year 2025, Volume: 29 Issue: 5, 1890 - 1895, 01.09.2025

Muntadher Jaber , Sada Ghalib Taher Riyadh Rashid Hameed Sajjad Mohammed Zorah Doha Jehad Mohammad Adyan Nafea Abbas Falah Herez Madhloom Alrabea Samer Kareem Hanoon

https://doi.org/10.12991/jrespharm.1763535

Abstract

Calcium supplements are commonly used by athletes, and they are also used to treat certain bone ailments,
however their cardiovascular safety is still debated. This study was designed to investigate the effect of calcium
supplements on troponin variables in athletes as well as those with bone diseases. The current study is case control
research included 180 participants (60 patients with bone problems, 60 athletes who use calcium supplements, and 60
healthy control subjects who do not take calcium supplements) and the levels of calcium and troponin measured for all
subjected group. The results showed that serum calcium levels in athlete's participants were significantly higher than
patients with bone diseases and healthy control subjects respectively (10.13 ± 1.2 vs 9.62 ± 0.92 and 8.57± 0.64,
respectively). Also, the calcium levels in patients with bone diseases was significantly higher than healthy control
subjects P< 0.001). Serum Troponine concentrations in patients with bone diseasesi and athletes participants were
significantly higher than controls (0.22 ± 0.07 and 0.21 ± 0.07 vs 0.06 ± 0.01, respectively, P>0.001). Results showed that
the Troponin levels correlate directly with serum calcium among study group which might be referred to that this
condition enhances production of Troponin in relation to serum calcium which in turn affected by the calcium
supplement administered that linked to a higher risk of myocardial infarction which lead to conclude that it is important
to utilize calcium supplements sparingly and aim to get the majority of the necessary daily intake of calcium from food
sources.

Keywords

Cardiac troponin , bone , calcium supplements , myocardium

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