Reworking potential of Cassava starch as a binder in the production of paracetamol tablets using wet granulation method

Year 2025, Volume: 29 Issue: 5, 1918 - 1929, 01.09.2025

Agatha Budi Susiana Lestari , Rika Eliana

https://doi.org/10.12991/jrespharm.1763611

Abstract

Paracetamol is a drug that is commonly used as an analgesic and antipyretic. In the pharmaceutical
industry, tablets are usually produced in large quantities, and it’s possible to find tablets that don’t fulfill the quality
standards after testing their physical properties, including hardness, friability, and disintegration time. One of the
excipients in tablets that may affect them is the binder, which in this study used cassava starch in two different
concentrations. This study was pure experimental research using a two-way completely randomized research design to
determine the effect of repeated compression on the potential of cassava starch as a binder with concentration levels,
based on the mixture and paracetamol tablets characteristics, which is done by crushing tablets that had been
compressed to test the physical properties of the mixture and tablets. The data obtained were analyzed statistically with
SPSS to check normality, then continued with TwoWay Anova if the data obtained were normally distributed or the
KruskalWallis test for abnormal distribution. The results showed that repeated compression affected the mixture
characteristics and tablet hardness. By analyzing the AUC of the compactibility test data, it was found that the reworking
potential value was greater, which showed that cassava starch could maintain its quality as a binder after being
recompressed twice.

Keywords

Cassava starch , paracetamol tablets , reworking potential , wet granulation

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