Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Year 2022, Volume: 26 Issue: 5, 1453 - 1460, 28.06.2025

Fatih Tok , Muhammed Oğuzhan Doğan Burçak Gürbüz , Bedia Kaymakçıoğlu

Abstract

In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The
antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia
coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata,
Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical
and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these
derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2
and 3 against yeast strains exhibited good antimicrobial activity.

Keywords

Pyrazoline , bacteria , yeast , MIC

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