Investigation of electrochemical behavior and voltammetric determination of the anti-inflammatory agent bufexamac

Year 2024, Volume: 28 Issue: 5, 1562 - 1571, 28.06.2025

Sariye İrem Kaya , Göksu Özçelikay Akyıldız

Abstract

This study aimed to develop an electrochemical method for the electrochemical determination of bufexamac (BUF), an important anti-inflammatory drug. For this purpose, the electrochemical properties of BUF were elucidated using a glassy carbon electrode (GCE) and cyclic voltammetry. The electrochemical performance of BUF was examined by the differential pulse voltammetry (DPV) method. It was observed that the response of GCE to DBT was linear in the concentration range of 6.0 × 10–6 M and 1.0 × 10–4 M. The limit of detection (LOD) was found to be 2.64 × 10−8 M; The limit of quantification (LOQ) was calculated as 8.79 × 10−8 M. The dexketoprofen tromethamine (DEX), diclofenac (DIC), and ibuprofen (IBU) were used as model active compounds to illustrate the oxidation mechanism of BUF. A simple, rapid, and sensitive electrochemical method for quantitatively determining BUF in a commercial sample of human serum was developed and validated. The calibration curve was linear in the 8.0 × 10–6 – 1.0 × 10–4 M in the biological media. The LOD for the commercial sample of human serum was set at 1.59 × 10−7 M. The electrochemical response of BUF in the presence of interferent was evaluated. The data obtained from the study showed that the developed method can be used in sensitive and selective BUF determination.

Keywords

Bufexamac , determination , electrochemical sensor , glassy carbon electrode , validation

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