The properties of nefopam as analgesic co-administration with caffeine as adjuvant in induced pain in mice

Year 2024, Volume: 28 Issue: 5, 1581 - 1591, 28.06.2025

Manar Gh. I. Alqaysi Nibras N. A. Alabbas

Abstract

This study aimed to evaluate nefopam's analgesic properties, explore caffeine's potential adjuvant effects, and examine its impact on renal and hepatic function. The study involved 56 female albino mice, divided into seven groups: Group A, as the control group, received distilled water; Group B received 0.75 mg per body weight of nefopam orally; Group C received 0.71 mg/B.W. of nefopam and 0.125 mg/B.W. of caffeine; Group D received 0.67 mg/B.W. of nefopam and 0.25 mg/B.W. of caffeine; and Group E received 0.63 mg/B.W. of nefopam and 0.37 mg/B.W. of caffeine. Group F received 0.6 mg/B.W. nefopam and 0.5 mg/B.W. caffeine orally; Group G received 0.56 mg/B.W. of nefopam and 0.62 mg/B.W. of caffeine. Several experimental models have been utilised to investigate the analgesic advantages. The hot plate test is a method used to assess the response time to thermal stimuli. Group D produced the most prolonged response duration to thermal stimuli, namely thermal pain, while the writhing test involves the injection of acetic acid, resulting in a significant decrease in the frequency of writhing observed in Group D. Inconclusion, Nefopam demonstrated analgesic properties in all experimental groups, even when augmented with caffeine, without any observed changes in renal or liver function.

Keywords

Analgesic , Nefopam , Caffeine , Hot Plate , Acetic acid , Renal test , Hepatic test

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