Effect of Intravenously Injected Arachidonic Acid on Electrocardiography in Rats

Year 2022, , 62 - 66, 31.12.2022

Esra Kaşıkçı , Murat Yalçın

https://doi.org/10.30782/jrvm.1124608

Cited By: 1

Abstract

Arachidonic acid (AA), which is released from phospholipids in the cell membrane by a variety of stimuli, has physiological and pathophysiological roles on the cardiovascular system. The current study designed to determine the effect of intravenously (iv) injected AA on the electrocardiography (ECG) of the anesthetized rats.
The ECG waves obtained from the lead II were written by placing electrodes to limbs of the ketamine and xylazine mixture (50 mg/kg/20 mg/kg; im) anesthetized adult Spraque Dawley rats. AA (3 mg/kg; iv) statistically significantly (p<0.05) caused to prolong of the ECG waves and intervals resulting in a decrease in the heart rate of the rats.
The current findings herein present the effect of the most abundant endogenous unsaturated fatty acid AA on ECG. The results clearly showed that AA could produce to bradycardia response by increasing the ECG waves and interval durations.

Keywords

Arachidonic acid, Electrocardiography, Intravenous, Heart rate

References

• Referans1 Das UN. Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review. J. Adv. Res. 2018;11:43-55.
• Referans2 Goodman DS. The role of arachidonic acid metabolites in cardiovascular homeostasis. Biochemical, histological and clinical cardiovascular effects of non-steroidal anti-inflammatory drugs and their interactions with cardiovascular drugs. Drugs 1987;33:47-55.
• Referans3 de Deckere EAM, ten Hoor F. PGF2 alpha stimulates release of PGE2 and PGI2 in the isolated perfused rat heart. Adv. Prostaglandin Thromboxane Res. 1980;7:655-8.
• Referans4 Isakson PC, Raz A, Denny SE, Pure E, Needleman P. A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart. Proc. Natl. Acad. Sci. USA 1977;74:101-5.
• Referans5 Dusting GJ, Moncada S, Vane JR. Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins 1977;13:3-15.
• Referans6 Heinroth-Hoffmann I, Giessler C, Mest HJ. Relevance of vasoactive mediators for the blood pressure effects of intravenous arachidonic acid injection in rats. Prostaglandins Leukot Essent Fatty Acids 1992;46:197-201.
• Referans7 Hill SR, Smith AJ. The response to arachidonic acid before and after non-steroidal anti-inflammatory drugs in normotensive and hypertensive rats. J. Hypertens. 1994;12:891-899.
• Referans8 Yalcin M. Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid Can. J. Physiol. Pharmacol. 2011;89:127-133.
• Referans9. Guvenc-Bayram G, Altinbas B, Erkan LG, Yalcin M. Modulation of arachidonic acid-evoked cardiorespiratory effects by the central lipoxygenase pathway. Respir Physiol Neurobiol. 2020;278:103441.
• Referans10 Hall JE. Cardiac Arrhythmias and their electrocardiographic interpretation. In: Hall JE, Guyton AC, Schmitt W, eds. Guyton and Hall Textbook of Medical Physiology. 12th ed. Saunders, London; 2011:143-153.
• Referans11 Wagner GS, Macfarlane P, Wellens H, et al. AHA/ ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part VI: acute ischemia/infarction: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol. 2009;53:1003-1011.
• Referans12 Zhang DY, Anderson AS. he Sympathetic Nervous System and Heart Failure. Cardiol Clin. 2014;32: 33–vii.
• Referans13 Pavlyuchenko VB, Moibenko AA. Effect of indomethacin-induced inhibition of arachidonic acid metabolism on the development of cardiogenic reflexes. Neurophysiology volume 1996;28:41-48.
• Referans14 Shaffer JE, Malik KU. Mechanism of action of arachidonic acid in the isolated perfused rat heart. Can. J. Physiol. Pharmacol. 1984;62:551-558.
• Referans15 Rapoport SI, Arachidonic acid and the brain. J. Nutr. 2008;138:2515-2520.
• Referans16 Yalcin M. Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid. Can. J. Physiol. Pharmacol. 2011;89:127-133.
• Referans17 Erkan LG, Altinbas B, Guvenc G, Aydin B, Niaz N, Yalcin M. The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F2α. Respir. Physiol. Neurobiol. 2017;242:117-124.
• Referans18 Strosznajder J, Chalimoniuk M, Strosznajder RP, Albanese V, Alberghina M. Arachidonate transport through the blood-retina and blood-brain barrier of the rat during aging. Neuroscience Lett. 1996;209:145-148.