The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis

Emine Özlem Gür; Atilla Çökmez; Akif Serhat Gür; Cüneyt Akaoğlu; Ercüment Tarcan; Sümer Deniz

The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis

Abstract

It has been demonstrated that nonsteroidal anti-inflammatory drug (NSAID)’s releasing prostaglandin inhibition, created some degree of suppression in the carcinogenesis of the colon. Many recent studies have been directed to underline the mechanism of the preventive effect of NSAID’s and especially aspirin in colonic carcinogenesis. The most frequent subject among these studies is the mutagenic effect of arachidonic acid metabolites. Malondialdehyde (MDA) is the product of arachidonic acid metabolism whose mutagenic effect has been shown, and MDA production can be prevented by cyclooxygenase inhibition. We performed an experimental study to demonstrate the effect of aspirin on the tissue MDA in colonic carcinogenesis. The study is built into four groups, consisting of ten rats each. Group 1: Control group; serum physiologic group, equal volumes to azoxymethane (AOM) is given two weeks subcutaneously, once every week. Group 2: AOM group; 15 mg/kg/week AOM is given subcutaneously for two weeks. Group 3: AOM + 1.4 mg/kg/day aspirin group; following the last dose of AOM, 1.4 mg/kg/day aspirin added to daily fluid doses. Group 4: AOM +5 mg/kg/day Aspirin group; following the last dose of AOM 5 mg/kg/day aspirin is added to the daily fluid doses. Fifty-two weeks after the last AOM dose laparotomy was performed on all the rats. The number, location, and dimension of all two moral masses in all groups were examined. Tumor volumes were calculated. The histopathologic examinations were done and both of the tumor and normal mucosa MDA measures were studied. According to the results, mucosa MDA measures were significantly higher in the other groups than group 1 (p<0.05). On the other hand, there was a significant difference between groups 2-4 (p=0.03) whether there wasn’t a significant difference between groups 2 and 3. When tumor MDA measures have been studied, there wasn’t a difference between 2 and 3, but the measures which have been established for group 4 were lower than either in group 2 or group 3 (p=0.02, p=0.001). Tumor volumes in group 2 were significantly higher than both of group 3 and group 4 (p=0.0009, p=0.0012). These results demonstrate that NSAIDs and aspirin have prevention effects on colonic carcinogenesis. However, there is no agreement about how the drugs affect the carcinogenesis. In this study, decreasing mutagenic activity which is linked to MDA, is one of the mechanisms that has been proved. Furthermore, it has been showed that this effect happens at anti analgesic doses

Keywords

Details

Primary Language

English

Subjects

Surgery

Journal Section

Research Article

Authors

Emine Özlem Gür ^* This is me
Türkiye

Atilla Çökmez This is me
Türkiye

Akif Serhat Gür This is me
Türkiye

Cüneyt Akaoğlu This is me
Türkiye

Ercüment Tarcan This is me
Türkiye

Sümer Deniz This is me
Türkiye

Publication Date

January 1, 2020

Submission Date

April 17, 2019

Acceptance Date

July 23, 2019

Published in Issue

Year 2020 Volume: 13 Number: 1

IZ

https://izlik.org/JA26WT96GS

Cite

RIS / Bibtex

APA

Gür, E. Ö., Çökmez, A., Gür, A. S., Akaoğlu, C., Tarcan, E., & Deniz, S. (2020). The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. Journal of Surgical Arts, 13(1), 16-21. https://izlik.org/JA26WT96GS

AMA

1.Gür EÖ, Çökmez A, Gür AS, Akaoğlu C, Tarcan E, Deniz S. The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. JSurgArts. 2020;13(1):16-21. https://izlik.org/JA26WT96GS

Chicago

Gür, Emine Özlem, Atilla Çökmez, Akif Serhat Gür, Cüneyt Akaoğlu, Ercüment Tarcan, and Sümer Deniz. 2020. “The Effect of Aspirin on Tissue Malondialdehyde Level in Azoxymethane-Induced Colon Carcinogenesis”. Journal of Surgical Arts 13 (1): 16-21. https://izlik.org/JA26WT96GS.

EndNote

Gür EÖ, Çökmez A, Gür AS, Akaoğlu C, Tarcan E, Deniz S (January 1, 2020) The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. Journal of Surgical Arts 13 1 16–21.

IEEE

[1]E. Ö. Gür, A. Çökmez, A. S. Gür, C. Akaoğlu, E. Tarcan, and S. Deniz, “The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis”, JSurgArts, vol. 13, no. 1, pp. 16–21, Jan. 2020, [Online]. Available: https://izlik.org/JA26WT96GS

ISNAD

Gür, Emine Özlem - Çökmez, Atilla - Gür, Akif Serhat - Akaoğlu, Cüneyt - Tarcan, Ercüment - Deniz, Sümer. “The Effect of Aspirin on Tissue Malondialdehyde Level in Azoxymethane-Induced Colon Carcinogenesis”. Journal of Surgical Arts 13/1 (January 1, 2020): 16-21. https://izlik.org/JA26WT96GS.

JAMA

1.Gür EÖ, Çökmez A, Gür AS, Akaoğlu C, Tarcan E, Deniz S. The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. JSurgArts. 2020;13:16–21.

MLA

Gür, Emine Özlem, et al. “The Effect of Aspirin on Tissue Malondialdehyde Level in Azoxymethane-Induced Colon Carcinogenesis”. Journal of Surgical Arts, vol. 13, no. 1, Jan. 2020, pp. 16-21, https://izlik.org/JA26WT96GS.

Vancouver

1.Emine Özlem Gür, Atilla Çökmez, Akif Serhat Gür, Cüneyt Akaoğlu, Ercüment Tarcan, Sümer Deniz. The effect of aspirin on tissue malondialdehyde level in azoxymethane-induced colon carcinogenesis. JSurgArts [Internet]. 2020 Jan. 1;13(1):16-21. Available from: https://izlik.org/JA26WT96GS