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FONKSİYONEL DİSPEPSİLİ HASTALARDA MİDE BOŞALMA ZAMANI VE BÖLGESEL DAĞILIMIN DEĞERLENDİRİLMESİ. EVALUATION OF GASTRIC EMPTYING AND REGIONAL FOOD DISTRIBUTION IN FUNCTIONAL DYSPEPSIA.

Year 2008, Volume: 1 Issue: 1, 14 - 22, 01.03.2008

Abstract

Functional dyspepsia is a syndrome characterized by symptoms such as epigastric pain, discomfort, early satiety, postprandial fullness and nausea that originate from the gastroduodenal region. The aim of our study is to evaluate the gastric emptying and regional distribution of food in patients with functional dyspepsia. Materials and Method; Seventeen patients with functional dyspepsia (F/M 10/7) and 12 healthy volunteers (F/M 6/6) were enrolled into the study. Following an 8-hour fast, one minute scintigraphic images were obtained in the anterior and posterior projection immediately, 30, 60, 90 and 120 min after a 500mCi (18MBq) Tc99m sulphur colloid-labeled egg, 2 slices of bread and 150 mL of orange juice ingestion. The per cent of radioactivity was calculated by dividing the gastric counts at each time period for total, proximal and distal stomach by the total counts at time zero. The gastric half emptying time (T1/2) was calculated from time activity curves. Results; Total gastric retention at initial and 30 min was not significantly different between patients with FD and controls, whereas a significant difference was observed in the total gastric emptying at 60, 90 and 120 minutes between groups. Although proximal gastric retention was higher in patients with FD compared with the normal subjects at initial, subsequently the ratio of the radioactivity in proximal stomach of FD patients decreased to a level significantly lower than that of controls after 60 min. Distal gastric retention was not significantly different at initial and 60 and 90 min between groups or even lower in FD patients compared to the normal subjects, whereas the values at 30 and 120 min. were even lower in the patients than that of controls. In conclusion, impaired gastric accommodation or early proximal emptying may be associated with symptoms in patients with functional dyspepsia. But early antral filling does not seem to be related to the symptoms.

FONKSİYONEL DİSPEPSİLİ HASTALARDA MİDE BOŞALMA ZAMANI VE BÖLGESEL DAĞILIMIN DEĞERLENDİRİLMESİ

Year 2008, Volume: 1 Issue: 1, 14 - 22, 01.03.2008

Abstract

Fonksiyonel dispepsi; orijini üst gastrointestinal sistem olan, abdominal ağrı, huzursuzluk, erken doyma, postprandial doygunluk ve bulantı ile seyreden bir sendromdur. Çalışmamızın amacı fonksiyonel dispepsili hastalarda, mide boşalma zamanı ve bölgesel dağılımı değerlendirmektir. Materyal ve Metod: Çalışmamıza fonksiyonel dispepsi tanısı alan 17 hasta (E/K: 7/10) ve sağlıklı 12 (E/K:6/6) gönüllü dahil edildi. Hastalar 8 saat açlıktan sonra, 500 mCi (18 MBq) Tc99m sülfür kolloid ile işaretli yumurta 2 dilim ekmek ve 150 ml portakal suyu ile yedikten hemen sonra, her biri 1 dakika olacak şekilde 0, 30, 60, 90 ve 120 inci dakikalarda anterior ve posterior projeksiyonlardan sayımlar alındı. Her bir zamanın Total, Proksimal ve Distal gastrik sayımları sıfır anındaki sayıma oranlanarak yüzdeleri hesaplandı. Zaman aktivite eğrisi kullanılarak mide boşalma zamanı (T1/2) hesap edildi. Bulgular: Total GR değerleri, 0. ve 30. dakikalardaki normal bireylerden anlamlı farklılık göstermemesine karşın, 60. 90. ve 120. dakikalarda normal bireylerden anlamlı azalma göstermiştir. Proksimal GR, 0 dakikada hasta grubunda kontrol grubuna oranla anlamlı yüksek bulunmasına rağmen diğer zamanlarda düşük bulundu. 30. dakikadaki azalma anlamlı olmamasına rağmen diğer zamanlardaki azalma istatistiksel olarak anlamlı idi. Hasta grubunda kontrole göre başlangıç ve 60-90. dakikalarda distal mide retansiyonu anlamlı olarak farklı değilken, 30. ve 120. dakikalardaki değerler anlamlı düşük bulundu. Sonuç: Bozulmuş gastrik uyum veya erken proksimal boşalma dispepsi ile ilişkili fakat erken antral dolma fonksiyonel dispepsi ile ilişkisizdir.

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Details

Other ID JA52VZ66SP
Journal Section Research Article
Authors

Eser Kaya This is me

İhsan Uslan This is me

Dursun Ali Şahin This is me

Publication Date March 1, 2008
Submission Date March 1, 2008
Published in Issue Year 2008 Volume: 1 Issue: 1

Cite

Vancouver Kaya E, Uslan İ, Şahin DA. FONKSİYONEL DİSPEPSİLİ HASTALARDA MİDE BOŞALMA ZAMANI VE BÖLGESEL DAĞILIMIN DEĞERLENDİRİLMESİ. EVALUATION OF GASTRIC EMPTYING AND REGIONAL FOOD DISTRIBUTION IN FUNCTIONAL DYSPEPSIA. JSurgArts. 2008;1(1):14-22.

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