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Diyabetik Ayak Enfeksiyonlu Hastalarda Tedavi Maliyet Analizi: Retrospektif Bir Çalışma

Year 2023, Volume: 2 Issue: 2, 47 - 54, 31.08.2023

Abstract

Giriş: Diyabetik ayak enfeksiyonu (DAE) ve diyabetik ayak ülserleri (DAÜ) diyabetin yaygın komplikasyonlarındandır. Önemli bir halk sağlığı sorunu olan DAÜ yönetimi ve tedavisi sağlık sistemlerinde önemli boyutlarda ekonomik yük oluşturmaktadır. Bu nedenle DAE tanısıyla kliniğimizde yatırılarak tedavi ve bakımı yapılan hastalardaki genel maliyet boyutunu ortaya koymayı amaçladık.
Materyal ve method: Retrospektif olarak gerçekleştirilen bu çalışmada kliniğimizde 1 Ocak 2018 ile 1 Ağustos 2020 tarihleri arasında DAE tanısıyla takip edilen 179 hasta dahil edildi. Hastanede yattıkları süre içerisindeki radyolojik görüntüleme, laboratuvar tetkikleri, muayene ve konsültasyon, yatak masrafı, medikal ve cerrahi tedavi (ampütasyon, debridman), pansuman maliyetleri dahil olmak üzere genel maliyet toplamları hesaplandı.
Bulgular: Çalışmaya dahil edilen 179 DAE’lu hastanın yaş ortalaması 61.5±10.9 yıl ve 122’si (%68.2) erkekti. Hastaların ortalama diyabet süresi 13.7±6.5 yıldı. DAÜ’li hastaların IDSA sınıflamasına göre %55.9’u orta derece olup, %41.3’ünde osteomiyelit bulunuyor ve %15.6’sı hiperbarik oksijen tedavisi alıyordu. Çalışmada genel amputasyon sıklığı %26.8 olup, %22.9’unu minör amputasyonlar oluşturuyordu. Amputasyonlu vakaların %7.3’ü (n=13) ise birden fazla amputasyon geçirmişti. Hastaların %54.7’sinin çalışma süresi kapsamında tekrarlayan hastane yatışları söz konusuydu. Vakalarda genel mortalite sıklığı ise %2.8 idi. DAÜ’li hastaların ortalama kişi başı tedavi maliyeti 9181.9±5155.3 TL idi. Kişi başı maliyet ile tekrarlayan hospitalizasyonu olan hastalar (p<0.001) hariç, incelenen değişkenlerin hiçbiri anlamlı ilişki göstermedi (tümü için p>0.05)
Sonuç: Hastaneye tekrarlayan yatışı olan hastalarla maliyet arasında anlamlı bir korelasyon vardır. DAÜ oluşumuna neden olan risk faktörleri ve ayak bakımını içeren farkındalık eğitim programları DM’lu hastalarda DAÜ oluşumunu ve buna bağlı gelişen ampütasyon gibi komplikasyon oranlarının azalmasına katkı sağlayacaktır.

References

  • Raspovic KM, Wukich DK. Self-reported quality of life and diabetic foot infections. J. Foot. J. Med 2017; 376: 2367–2375.
  • Singer AJ, Tassiopoulos, Kirsner RS. Evaluation and Management of Lower-Extremity Ulcers. N Engl J Med 2018; 378(3): 302-303.
  • Lauri C, Leone A, Cavallini M, Signore A, Giurato L, Uccioli L. Diabetic Foot Infections: The Diagnostic Challenges. J Clin Med 2020; 9(6): 1779.
  • Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med 2017; 376: 2367–2375.
  • Lavery LA, Armstrong DG, Murdoch DP, Peters EJ, Lipsky BA. Validation of the Infectious Diseases Society of America's diabetic foot infection classification system. Clin Infect Dis 2007; 44: 562–565.
  • Ragnarson Tennvall R, Apelqvist J. Health-Economic Consequences of Diabetic Foot Lesions. Clinical Infectious Diseases 2004; 39(2): 132-139.
  • Karagöz G, Kadanalı A, Öztürk S, Öztürk S, Çakar ŞE, Çomoğlu Ş, Doğan F. The analysis of the cost and amputation rates of hospitalized diabetic foot infection patients. Int J Diabetes Dev Ctries 2017; 37(2): 201–205.
  • Tabur S, Eren MA, Çelik Y, Dağ OF, Sabuncu T, Sayiner ZA, Savas E. The major predictors of amputation and length of stay in diabetic patients with acute foot ulceration. Wien Klin Wochenschr 2015; 127: 45–50.
  • Hoffstad O, Mitra N, Walsh J, Margolis DJ. Diabetes, lowerextremity amputation, and death. Diabetes Care 2015; 38: 1852–1857.
  • Lawrence SM, Wraight PR, Campbell DA, Colman PG. Assessment and management of inpatients with acute diabetes-related foot complications: room for improvement. Intern Med J 2004; 34(5): 229–233.
  • Nather A, Bee CS, Huak CY, Chew JL, Lin CB, Neo S, Sim EY. Epidemiology of diabetic foot problems and predictive factors for limb loss. J Diabetes Complications 2008; 22(2): 77–82.
  • Rezende KF, Nunes MA, Melo NH, Malerbi D, Chacra AR, Ferraz MB. In hospital care for diabetic foot: a comparison between the estimated cost and the SUS reimbursement. Arq Bras Endocrinol Metabol 2008; 52(3): 523–530.
  • Alay H, Yılmaz S, Kesmez Can F, Parlak M. An evaluation of risk factors affecting amputation in patients with diabetic foot infection. J Health Sci Med 2021; 4(1): 49-54.
  • Lavery LA, Armstrong DG, Wunderlich RP, Boulton AJM, Tredwell JL. Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care 2003; 26:1435–1438.
  • Bozkurt F, Tekin R, Çelen MK, Ayaz C. Wagner classification and culture analysis of diabetic foot infection. Dicle Tıp Dergisi. 2011; 38(1): 31 - 34.
  • Apelqvist J, Ragnarson Tennvall G, Persson U, Larsson J. Diabetic foot ulcers in a multidisciplinary setting: an economic analysis of primary healing and healing with amputation. J Intern Med 1994; 235: 463–471.
  • Ragnarson Tennvall G, Apelqvist J, Eneroth M. Costs of deep foot infections in patients with diabetes mellitus. Pharmacoeconomics 2000; 18: 225–238.
  • Gonen MS, Cakir M, Gonulalan G, Ozturk M, Ipekci SH, Kosker A, Karalezli MN, Eryaman I, Durgut K, Keskin M, Seyhan N. The problems and cost-effectiveness analysis of diabetic foot infections. Turk J Endocrinol Metab 2012; 16: 10–13.
  • Keskek SO, Kirim S, Yanmaz N. Estimated costs of the treatment of diabetic foot ulcers in a tertiary hospital in Turkey. Pak J Med Sci 2014; 30: 968–971.
  • Bao X, Yang C, Fang K, Shi M, Yu G, Hu Y. Hospitalization costs and complications in hospitalized patients with type 2 diabetes mellitus in Beijing. China J Diabetes 2017; 9(4): 405-411.
  • Tchero H, Kangambega P, Lin L, Mukisi-Mukaza M, Brunet-Houdard S, et al. Cost of diabetic foot in France, Spain, Italy, Germany and United Kingdom: A systemetic review. Ann Endocrinol (Paris) 2018; 79(2): 67-74.
  • Struijs JN, Baan CA, Schellevis FG, Westert GP, van den Bos GA. Comorbidity in patients with diabetes mellitus: impact on medical health care utilization. BMC Health Serv Res 2006; 6: 84.

Treatment Cost Analysis in Patients with Diabetic Foot Infection: A Retrospective Study

Year 2023, Volume: 2 Issue: 2, 47 - 54, 31.08.2023

Abstract

Introduction: Diabetic foot infection (DFI) and diabetic foot ulcer (DFU) are widespread complications of diabetes. The management and treatment of DFU, an important public health problem, can result in a significant economic burden on health systems. The purpose of this study was to reveal the general cost dimension in patients hospitalized in our clinic for treatment and care with diagnoses of DFI.
Materials and methods: One hundred seventy-nine patients followed-up with diagnoses of DFI in our clinic between 1 January, 2018, and 1 August, 2020, were included in this retrospective study. General cost totals including radiological imaging, laboratory tests, examination and consultation, bed costs, medical and surgical treatment (amputation, debridement), and dressing costs during patients’ hospital stays were calculated.
Results: The mean age of the 179 patients with DFI in this study was 61.5±10.9 years, and 122 (68.2%) were men. Mean duration of diabetes was 13.7±6.5 years. Based on the Infectious Disease Society of America classification, 55.9% of the cases with DFU were moderate, osteomyelitis was present in 41.3%, and 15.6% were receiving hyperbaric therapy. The general prevalence of amputation was 26.8%, with minor amputations representing 22.9%. Thirteen (7.3%) of the amputation cases had undergone more than one amputation. Repeat hospitalizations were observed in 54.7% of the patients during the study period. The general mortality rate was 2.8%. The mean treatment cost per capita among the patients with DFU was 9181.9±5155.3 Turkish lira. With the exception of the repeat hospitalization cases (p<0.001), no significant association was determined between per capita cost and any of the demographic and clinical variables investigated(p>0.05 for all).
Conclusion: There is a significant correlation between patients with repeated hospitalizations and cost. Awareness training programs including risk factors and foot care will contribute to a decrease in DFU development and related complications such as amputation in patients with diabetes mellitus.

References

  • Raspovic KM, Wukich DK. Self-reported quality of life and diabetic foot infections. J. Foot. J. Med 2017; 376: 2367–2375.
  • Singer AJ, Tassiopoulos, Kirsner RS. Evaluation and Management of Lower-Extremity Ulcers. N Engl J Med 2018; 378(3): 302-303.
  • Lauri C, Leone A, Cavallini M, Signore A, Giurato L, Uccioli L. Diabetic Foot Infections: The Diagnostic Challenges. J Clin Med 2020; 9(6): 1779.
  • Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med 2017; 376: 2367–2375.
  • Lavery LA, Armstrong DG, Murdoch DP, Peters EJ, Lipsky BA. Validation of the Infectious Diseases Society of America's diabetic foot infection classification system. Clin Infect Dis 2007; 44: 562–565.
  • Ragnarson Tennvall R, Apelqvist J. Health-Economic Consequences of Diabetic Foot Lesions. Clinical Infectious Diseases 2004; 39(2): 132-139.
  • Karagöz G, Kadanalı A, Öztürk S, Öztürk S, Çakar ŞE, Çomoğlu Ş, Doğan F. The analysis of the cost and amputation rates of hospitalized diabetic foot infection patients. Int J Diabetes Dev Ctries 2017; 37(2): 201–205.
  • Tabur S, Eren MA, Çelik Y, Dağ OF, Sabuncu T, Sayiner ZA, Savas E. The major predictors of amputation and length of stay in diabetic patients with acute foot ulceration. Wien Klin Wochenschr 2015; 127: 45–50.
  • Hoffstad O, Mitra N, Walsh J, Margolis DJ. Diabetes, lowerextremity amputation, and death. Diabetes Care 2015; 38: 1852–1857.
  • Lawrence SM, Wraight PR, Campbell DA, Colman PG. Assessment and management of inpatients with acute diabetes-related foot complications: room for improvement. Intern Med J 2004; 34(5): 229–233.
  • Nather A, Bee CS, Huak CY, Chew JL, Lin CB, Neo S, Sim EY. Epidemiology of diabetic foot problems and predictive factors for limb loss. J Diabetes Complications 2008; 22(2): 77–82.
  • Rezende KF, Nunes MA, Melo NH, Malerbi D, Chacra AR, Ferraz MB. In hospital care for diabetic foot: a comparison between the estimated cost and the SUS reimbursement. Arq Bras Endocrinol Metabol 2008; 52(3): 523–530.
  • Alay H, Yılmaz S, Kesmez Can F, Parlak M. An evaluation of risk factors affecting amputation in patients with diabetic foot infection. J Health Sci Med 2021; 4(1): 49-54.
  • Lavery LA, Armstrong DG, Wunderlich RP, Boulton AJM, Tredwell JL. Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care 2003; 26:1435–1438.
  • Bozkurt F, Tekin R, Çelen MK, Ayaz C. Wagner classification and culture analysis of diabetic foot infection. Dicle Tıp Dergisi. 2011; 38(1): 31 - 34.
  • Apelqvist J, Ragnarson Tennvall G, Persson U, Larsson J. Diabetic foot ulcers in a multidisciplinary setting: an economic analysis of primary healing and healing with amputation. J Intern Med 1994; 235: 463–471.
  • Ragnarson Tennvall G, Apelqvist J, Eneroth M. Costs of deep foot infections in patients with diabetes mellitus. Pharmacoeconomics 2000; 18: 225–238.
  • Gonen MS, Cakir M, Gonulalan G, Ozturk M, Ipekci SH, Kosker A, Karalezli MN, Eryaman I, Durgut K, Keskin M, Seyhan N. The problems and cost-effectiveness analysis of diabetic foot infections. Turk J Endocrinol Metab 2012; 16: 10–13.
  • Keskek SO, Kirim S, Yanmaz N. Estimated costs of the treatment of diabetic foot ulcers in a tertiary hospital in Turkey. Pak J Med Sci 2014; 30: 968–971.
  • Bao X, Yang C, Fang K, Shi M, Yu G, Hu Y. Hospitalization costs and complications in hospitalized patients with type 2 diabetes mellitus in Beijing. China J Diabetes 2017; 9(4): 405-411.
  • Tchero H, Kangambega P, Lin L, Mukisi-Mukaza M, Brunet-Houdard S, et al. Cost of diabetic foot in France, Spain, Italy, Germany and United Kingdom: A systemetic review. Ann Endocrinol (Paris) 2018; 79(2): 67-74.
  • Struijs JN, Baan CA, Schellevis FG, Westert GP, van den Bos GA. Comorbidity in patients with diabetes mellitus: impact on medical health care utilization. BMC Health Serv Res 2006; 6: 84.
There are 22 citations in total.

Details

Primary Language English
Subjects Surgery, Surgery (Other)
Journal Section Research Articles
Authors

Handan Alay 0000-0002-4406-014X

Sinan Yılmaz 0000-0001-7784-3274

Fatma Kesmez Can 0000-0001-8085-7589

Zülal Özkurt 0000-0001-5554-8768

Zeynep Selin Vural 0000-0002-3471-3135

Ayse Albayrak 0000-0002-6177-4566

Kemalettin Özden 0000-0003-3293-5671

Esra Çınar Tanrıverdi 0000-0001-8857-3986

Publication Date August 31, 2023
Submission Date May 29, 2023
Published in Issue Year 2023 Volume: 2 Issue: 2

Cite

AMA Alay H, Yılmaz S, Kesmez Can F, Özkurt Z, Vural ZS, Albayrak A, Özden K, Çınar Tanrıverdi E. Treatment Cost Analysis in Patients with Diabetic Foot Infection: A Retrospective Study. JSMS. August 2023;2(2):47-54.