MORPHOLOGICAL, HEMATOLOGICAL and HISTOPATHOLOGICAL EFFECTS of PROPYL PARABEN on ENDOCRINE GLANDS of MALE RATS at PREPUBERTAL PERIOD

Abstract

Propyl paraben (propyl 4-Hydroxybenzoate) is frequently used in various products due to its physical and chemical properties and cheapness, and its use is increasing day by day due to the development of the industrial industry. This study is conducted on the side effects of propyl paraben on male rats' endocrine glands. Accordingly, each oil control, positive control (3 mg/kg/day flutamide=FLU), negative control (0.4 mg/kg/day testosterone propionate = TP) and 10, 250 and 750 mg/kg/day testosterone propionate + propyl paraben 6 groups were formed, one of which had six rats.

While a decrease was observed in thymus and spleen weights in the 10, 250 and 750 mg/kg/day testosterone propionate + propyl paraben dose groups compared to the fat control group, an increase was observed in the weight of the thyroid tissue in the 250 mg/kg/day testosterone propionate + propyl paraben dose group compared to the positive control and 10 mg/kg/day testosterone propionate + propyl paraben dose groups. It has also been shown with various damages in endocrine organs in histopathological examinations. Therefore, we can say that propyl paraben has a negative effect on the endocrine organs examined.

Keywords

• Propyl paraben
• Endocrine glands
• Toxicity
• Prepubertal male rats

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