Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid

Halil İlkimen; Cengiz Yenikaya; Aysel Gülbandılar

doi:10.59313/jsr-a.1816079

Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid

Abstract

In this study, the salts {(Habt)(Hdpc) (3), (Habt)(Hdpc)₂ (6), (HMeabt)(Hdpc).H₂O (12), (HMeOabt)(Hdpc) (18)} obtained from 2,6-pyridinedicarboxylic acid (H₂dpc) and 2-aminobenzothiazole (abt), 2-amino-6-chlorobenzothiazole (Clabt), 2-amino-6-methylbenzothiazole (Meabt), and 2-amino-6-methoxybenzothiazole (MeOabt), and metal complexes of 1 {Fe(III) (Habt)[Fe(dpc)].4H₂O (2), Co(II) (Habt)₂[Co(dpc)].3H₂O (3), Ni(II) (Habt)₂[Ni(dpc)].4H₂O (4), Cu(II) [Cu(dpc)(abt)(H₂O)] (5)}, of 6 {Fe(III) (HClabt)[Fe(dpc)].5H₂O (7), Co(II) (HClabt)₂[Co(dpc)].H₂O (8), Ni(II) (HClabt)₂[Ni(dpc)].H₂O (9), Cu(II) [Cu(dpc)(Clabt)(H₂O)]₂ (10), Cu(II) (HClabt)₂[Cu(dpc)].H₂O (11)}, of 12 {Fe(II) (HMeabt)₂[Fe(dpc)].H₂O (13), Fe(III) (HMeabt)[Fe(dpc)].5H₂O (14), Co(II) (HMeabt)₂[Co(dpc)].H₂O (15), Ni(II) (HMeabt)₂[Ni(dpc)].H₂O (16), Cu(II) (HMeabt)₂[Cu(dpc)].H₂O (17)}, of 18 {Fe(III) (HMeOabt)[Fe(dpc)].2H₂O (19), Co(II) (HMeOabt)₂[Co(dpc)].4H₂O (20), Ni(II) (HMeOabt)₂[Ni(dpc)].H₂O (21), Cu(II) (HMeOabt)₂[Cu(dpc)].H₂O (22)} were synthesized by the methods found in the literature. The metal percentages in the structures of the synthesized compounds (2-5, 7-11, 14-17, and 19-22) were compared with those in the literature using Atomic Absorption Spectroscopy (AAS). Furthermore, the antimicrobial properties of all compounds have also been tested against C. albicans (antifungal activity) and E. Coli, P. aeruginosa, B. subtilis, S. aureus, L. monocytogenes, and E. faecalis (antibacterial activity). The results were compared with those obtained using the control compounds Fluconazole and Ketoconazole (antifungal activity) and Vancomycin, Levofloxacin, Cefepime, and Chloramphenicol (antibacterial activity). As a result of activity studies, newly synthesized compounds show activity against bacteria and yeasts. Specifically, compound 9 demonstrated superior activity against all bacteria and yeasts. Compounds Clabt and 18 showed good activity against C. albicans compared to control compounds. In conclusion, it is suggested that all compounds have potential applications in inhibiting bacterial and yeast growth. Consequently, all compounds are proposed to have potential applications in inhibiting bacterial and yeast growth.

Keywords

Project Number

2022-03

Thanks

The authors acknowledge the support provided by Kütahya Dumlupınar University Research Fund (grant No. 2022–03).

References

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Details

Primary Language

English

Subjects

Microbiology (Other)

Journal Section

Research Article

Authors

Halil İlkimen ^*
0000-0003-1747-159X
Türkiye

Cengiz Yenikaya
0000-0002-5867-9146
Türkiye

Aysel Gülbandılar
0000-0001-9075-9923
Türkiye

Publication Date

June 30, 2026

Submission Date

November 2, 2025

Acceptance Date

March 30, 2026

Published in Issue

Year 2026 Number: 065

DOI

https://doi.org/10.59313/jsr-a.1816079

IZ

https://izlik.org/JA86TW59RU

Cite

RIS / Bibtex

APA

İlkimen, H., Yenikaya, C., & Gülbandılar, A. (2026). Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid. Journal of Scientific Reports-A, 065, 84-92. https://doi.org/10.59313/jsr-a.1816079

AMA

1.İlkimen H, Yenikaya C, Gülbandılar A. Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid. JSR-A. 2026;(065):84-92. doi:10.59313/jsr-a.1816079

Chicago

İlkimen, Halil, Cengiz Yenikaya, and Aysel Gülbandılar. 2026. “Antimicrobial Activity Studies of Salt and Metal Complexes of 2-Aminobenzothiazole Derivatives and 2,6-Pyridinedicarboxylic Acid”. Journal of Scientific Reports-A, nos. 065: 84-92. https://doi.org/10.59313/jsr-a.1816079.

EndNote

İlkimen H, Yenikaya C, Gülbandılar A (June 1, 2026) Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid. Journal of Scientific Reports-A 065 84–92.

IEEE

[1]H. İlkimen, C. Yenikaya, and A. Gülbandılar, “Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid”, JSR-A, no. 065, pp. 84–92, June 2026, doi: 10.59313/jsr-a.1816079.

ISNAD

İlkimen, Halil - Yenikaya, Cengiz - Gülbandılar, Aysel. “Antimicrobial Activity Studies of Salt and Metal Complexes of 2-Aminobenzothiazole Derivatives and 2,6-Pyridinedicarboxylic Acid”. Journal of Scientific Reports-A. 065 (June 1, 2026): 84-92. https://doi.org/10.59313/jsr-a.1816079.

JAMA

1.İlkimen H, Yenikaya C, Gülbandılar A. Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid. JSR-A. 2026;:84–92.

MLA

İlkimen, Halil, et al. “Antimicrobial Activity Studies of Salt and Metal Complexes of 2-Aminobenzothiazole Derivatives and 2,6-Pyridinedicarboxylic Acid”. Journal of Scientific Reports-A, no. 065, June 2026, pp. 84-92, doi:10.59313/jsr-a.1816079.

Vancouver

1.Halil İlkimen, Cengiz Yenikaya, Aysel Gülbandılar. Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid. JSR-A. 2026 Jun. 1;(065):84-92. doi:10.59313/jsr-a.1816079