Research Article
BibTex RIS Cite
Year 2020, Issue: 045, 28 - 49, 31.12.2020

Abstract

References

  • [1] Martini, F. H., (2003), Fundamentals of Anatomy & Physiology, 6. Baskı, Yayımlayan Addison Wesley Longman, s. 1004.
  • [2] Hole, J.W., (1993), Human Anatomy and Physiology, 6. Baskı, William C. Brown Publisher, s. 770.
  • [3] Demirci, A., Canda, E.C., (2010), AĢırı Aktif Mesanenin Patofizyolojisi, Türk Üroloji Seminerleri, 1: 23-6.
  • [4] Tahata, S., Yuan, B., Kikuchi, H., Tagaki, N., Hirano, T., Toyoda, H., (2014), Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin, International Journal of Oncology, 45(4): 1749-1759.
  • [5] Şengül, E., (2014), Achillea Millefolium (Civan perçemi) Ekstraktlarının ve Bazı Biyolojik Aktif Bileşiklerinin In Vitro Ortamda Rat Mesanesi Düz Kasları Üzerine Etkilerinin Araştırılması, Doktora Tezi, Atatürk Üniversitesi, Erzurum, s. 2, 101.
  • [6] Ege, H., (2016), Silodosin ve Palonosetronun İzole Sıçan Mesane Kasılmaları Üzerindeki Etkileri, Yüksek Lisans Tezi, Necmettin Erbakan Üniversitesi, Konya, s. 2, 42, 43, 44.
  • [7] Agis-Torres, A., Recio, P., López-Oliva, M.E., Martínez, M.P., Barahona, M.V., Benedito, S., Bustamante, S., Jiménez-Cidre, M.A., García-Sacristán, A., Prieto, D., Fernandes, V.S., Hernández, M., (2018), Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission, Scientific Reports, 8: 4711.
  • [8] Ozturk Fincan G.S., Vural I.M., Yildirim S.S., Isli F., Dilekoz E., Ercan S., Sarioglu Y., (2016), Role of nicotinic acetylcholine receptor subtypes on nicotine's enhancing effect on electrical field stimulation elicited contractile responses in rabbit urine bladder, European Review for Medical and Pharmacological Sciences, 20(8): 1636-1641.
  • [9] Andersson, M., Aronsson, P., Doufish, D., Lampert, A., Tobin, G., (2012), Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder, Autonomic Neuroscience: Basic and Clinical, 170(1-2): 5-11.
  • [10] Darblade, B., Behr-Roussel, D., Oger, S., Hieble, J.P., Lebret, T., Gorny, D., Benoit, G., Alexandre, L., Giuliano, F., (2006), Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder, Urology, 68(2): 442-8.
  • [11] Giglio, D., Tobin, G., (2009), Muscarinic receptor subtypes in the lower urinary tract, Pharmacology, 83(5): 259-69.
  • [12] Hegde, S.S., Eglen, R.M., (1999), Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder, Life Sciences, 64(6-7): 419-28.
  • [13] Lüllmann, H., Hein, L., Mohr, K., Bieger, D., (2005), Color Atlas of Pharmacology, 3. Baskı, Thieme Publishers New York, s. 6, 7, 54.
  • [14] Brunton, L., Chabner, B., Knollman, B., (2010), Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12. Baskı, McGraw-Hill Higher Education, s. 214-320.
  • [15] Altinkurt, O., (1981), Farmakoloji I, Ankara Üniversitesi Basımevi, Ankara, s. 35, 105.
  • [16] Katzung, B.G., Masters, S.B., Trevor, A.J., (2012), Basic & Clinical Pharmacology, 12.Baskı, McGraw-Hill Higher Education, s. 87, 152.
  • [17] Kayaalp, S.O., (2002), Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, 10.Baskı, Hacettepe-Taş, Ankara, s. 1093-1138.
  • [18] Guyton A.C. and Hall, J.E., (2013), Tıbbi Fizyoloji (çev. Yeğen, B.), 12. Baskı, Nobel Tıp Kitabevleri, s. 91, 307, 308, 731, 773.
  • [19] Thorneloe, K.S. and Nelson, M.T., (2005), Ion channels in smooth muscle: regulators of intracellular calcium and contractility, Canadian Journal of Physiology and Pharmacology, 83: 215–242.
  • [20] Bisset, D. and Chung, S.H., (2008), Efficacy of external tetraethylammonium block of the KcsA potassium channel: molecular and Brownian dynamics studies, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778(10): 2273-82.
  • [21] Gür, S., (1998), Mesane’nin Non-adrenerjik Non-kolinerjik Kontrolü, Ankara Eczacılık Fakültesi Dergisi, 27(1): 51-60.
  • [22] Vesela, R., Aronsson, P., Andersson, M., Wsol, V., Tobin, G., (2012), The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis/painful bladder syndrome, Journal of Physiology and Pharmacology, 63(3): 209-16.
  • [23] Daly, D.M., 1, Collins, V.M., Chapple, C.R., Grundy, D., (2011), The afferent system and its role in lower urinary tract dysfunction, Current Opinion in Urology, 21: 268–274.
  • [24] Gohar, O., (2005), The Transient Receptor Potential (TRP) Ion Channels, Modulator, 20: 20-23.
  • [25] Araki, I., Du, S., Kobayashi, H., Sawada, N., Mochizuki, T., Zakoji, H., Takeda, M., (2008), Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder, International Journal of Urology, 15(8): 681-687.
  • [26] Si, X., McManus, BM., Zhang, J., Yuan, J., Cheung, C., Esfandiarei, M., Suarez, A., Morgan, A., Luo, H., (2005), Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway, Journal of Virology, 79(13): 8014–8023.
  • [27] Xiang, N., Liu, J., Liao, Y., Huang, Y., Wu, Z., Bai, Z., Lin, X., Zhang, J., (2016), Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway, Scientific Reports, 6: 27583. 57
  • [28] Zhang, J., Jiang, W., Zuo, Z., (2014), Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor kappaB, Neuroscience, 261: 1-10.
  • [29] Ivan, A.L., Campanini, M.Z., Martinez, R.M., Ferreira, V.S., Steffen, V.S., Vicentini, F.T., Vilela, F.M., Martins, F.S., Zarpelon, A.C., Cunha, T.M., Fonseca, M.J., Baracat, A.A., Georgetti, S.R., Verri, W.A.Jr., Casagrande, R., (2014), Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro, Journal of Photochemistry and Photobiology B: Biology, 138: 124-33.
  • [30] İnan, O. A., (2015), Sıçan Mesane’si Düz Kası Kasılma-GevĢeme Yanıtları Üzerine Ammonium Pyrrolidine Dithiocarbamate, SG-Benz, Caffeic Acid Phenil Ester, Atorvastatin Kalsiyum’ un Etkileri, Yüksek Lisans Tezi, Dumlupınar Üniveristesi Fen Bilimleri Enstitüsü, Kütahya, s. 39.
  • [31] K Lanke, BM Krenn, W J G Melchers, J Seipelt and FJM van Kuppeveld, (2007), PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells, J Gen Virol. 88 (Pt 4): 1206-1217. doi: 10.1099 / vir.0.82634-0. PMID: 17374764 DOI: 10.1099 / vir.0.82634-0.
  • [32] Yanjie D., Qing Z., Laifang W., (2019), Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes, Chem Biol Interact., 306:131-137. doi: 10.1016 / j.cbi.2019.04.025. PMID: 31004595 DOI: 10.1016 / j.cbi.2019.04.025.
  • [33] Eun H. L., Seon K. S., Su R. S., (2017), Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction, Biochem Pharmacol.; 143:107-117. doi: 10.1016 / j.bcp.2017.07.011. PMID: 28712932 DOI: 10.1016 / j.bcp.2017.07.011 .
  • [34] Han, J.S., Kim, S.J., Nam, Y., Lee, H.Y., Kim, G.M., Kim, D.M., Sohn, U.D., (2019), The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat, Biomolecules & Therapeutics, 27 (1): 101-106.
  • [35] Hai Z., Daoda C., Jinghui Z., Yuan T., (2004), Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells, J Huazhong Univ Sci Technolog Med Sci.; 24 (2): 140-3, 157. doi: 10.1007 / BF02885413. PMID: 15315164 DOI: 10.1007 / BF02885413.
  • [36] Rembetski, B.E., Cobine, C.A., Drumm, B.T., (2018), Laboratory practical to study the differential innervation pathways of urinary tract smooth muscle, American Physiological Society, 1;42(2): 295-304.
  • [37] A Kondo, M Mogi, Y Koshihara, A Togari., (2001), Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells, Biochem Pharmacol.; 61(3):319-26. doi: 10.1016/s0006-2952(00)00544-x. PMID: 11172736 DOI: 10.1016/s0006-2952(00)00544-x.
  • [38] Rogers, M.J., Xiao, Z., Shen, B., Wang, J., Schwen, Z., Roppolo, J.R., de Groat, W.C., Tai, C., (2015), Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats, American Physiological Society, 1;308(1): R42-9.
  • [39] Hong F., Chounghun K., Jonathan R. D., Ryan K., Iwalola A., Yong Z., Li L. J., (2013), Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade, Exp Physiol.; 98 (3): 784-95. doi: 10.1113 / expphysiol.2012.069286. PMID: 23104933 DOI: 10.1113 / expphysiol.2012.069286.
  • [40] Zar, M.A., Iravani, M.M., Luheshi, G.N., (1990), Effect of nifedipine on the contractile responses of the isolated rat bladder, The Journal of Urology, 143(4): 835-9.
  • [41] Rud, T,. Andersson, K.E., Ulmsten, U., (1979), Effects of Nifedipine in Women with Unstable Bladders, Urologia Internationalis, 34: 421–429.
  • [42] Maggi, C.A., Manzini, S., Parlani, M., Conte, B., Giuliani, S., Meli, A., (1988), The effect of nifedipine on spontaneous, drug-induced and reflexly-activated contractions of the rat urinary bladder: evidence for the participation of an intracellular calcium store to micturition contraction, General Pharmacology: The Vascular System, 19(1): 73-81.
  • [43] Soichiro I., Shouji M., Kosuke O., Masataka I., Akihito I., Tomonori T., Nobuyuki E., Taishi Y., Masashi S., Hiroko D., Sachio M., Tomomi I., Hiroyuki T., (2019), Blockade of L-type Ca 2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway, Sci Rep.; 9(1):9850. doi: 10.1038 / s41598-019-46367-6. PMID: 31285514 PMCID: PMC6614470 DOI: 10.1038 / s41598-019-46367-6.
  • [44] Carpenter, F.G., (1978), Potentiation of nevre-induced bladder responses by tetraethylammonium in reletion to junctionaland extrajunctional muscarinic receptors, British journal of pharmacology, 64(3): 331-9.
  • [45] Oh, S.J., Ahn, S.C., (2003), Inhibitory effects of potassium channel blockers on carbachol induced contraction in rat detrusor muscle, Journal of Korean Medical Science, 18(5): 701-6.

THE INVESTIGATION OF THE ACTION MECHANISM OF AMMONIUM PYRROLIDINE DITHIOCARBAMATE ON RAT BLADDER SMOOTH MUSCLE CONTRACTION-RELAXATION RESPONSES

Year 2020, Issue: 045, 28 - 49, 31.12.2020

Abstract

Ammonium pyrrolidine dithiocarbamate (PDTC), the specific inhibitor of NF-κB, is a thiol compound with anti-viral, anti-apoptotic, anti-inflammatory and antioxidant effects proven in many studies. There is not sufficient literature in what fashion that APDTC has produced these effects. We aimed to investigate the action mechanism of APDTC in rat bladder smooth muscle in our vitro study. In our study, 70 Wistar albino male rats were used. The rats were euthanized by cervical dislocation under the anesthesia and then abdomens were opened and bladders were isolated. After the removal of the connective tissues around the bladders, they were placed in the organ bath containing Krebs solution. KCl, ACh, APDTC, Atropine, Phentolamine, Propranolol, Nifedipine and TEA were applied to the bath with an appropriate protocol. The obtained data were evaluated with Kruskal Wallis and Mann-Whitney U tests. ACh induced bladder produced APDTC relaxation response in its own smooth muscle. Cholinergic receptor blocker Atropine, β-adrenergic receptor blocker Propranolol, L-type calcium channel blocker Nifedipine and atropine+phentolamine+propranolol mix have not changed the relaxation response that APDTC produced. In the presence of potassium channel blocker TEA, APDTC produced contraction response, but this was not a significantly important grade response. In the presence of α-adrenergic receptor blocker Phentolamine, APDTC produced significant contractile response. As a result, we think that APDTC shows its effect on rat bladder smooth muscle via α-adrenergic receptors and NANK system.

References

  • [1] Martini, F. H., (2003), Fundamentals of Anatomy & Physiology, 6. Baskı, Yayımlayan Addison Wesley Longman, s. 1004.
  • [2] Hole, J.W., (1993), Human Anatomy and Physiology, 6. Baskı, William C. Brown Publisher, s. 770.
  • [3] Demirci, A., Canda, E.C., (2010), AĢırı Aktif Mesanenin Patofizyolojisi, Türk Üroloji Seminerleri, 1: 23-6.
  • [4] Tahata, S., Yuan, B., Kikuchi, H., Tagaki, N., Hirano, T., Toyoda, H., (2014), Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin, International Journal of Oncology, 45(4): 1749-1759.
  • [5] Şengül, E., (2014), Achillea Millefolium (Civan perçemi) Ekstraktlarının ve Bazı Biyolojik Aktif Bileşiklerinin In Vitro Ortamda Rat Mesanesi Düz Kasları Üzerine Etkilerinin Araştırılması, Doktora Tezi, Atatürk Üniversitesi, Erzurum, s. 2, 101.
  • [6] Ege, H., (2016), Silodosin ve Palonosetronun İzole Sıçan Mesane Kasılmaları Üzerindeki Etkileri, Yüksek Lisans Tezi, Necmettin Erbakan Üniversitesi, Konya, s. 2, 42, 43, 44.
  • [7] Agis-Torres, A., Recio, P., López-Oliva, M.E., Martínez, M.P., Barahona, M.V., Benedito, S., Bustamante, S., Jiménez-Cidre, M.A., García-Sacristán, A., Prieto, D., Fernandes, V.S., Hernández, M., (2018), Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission, Scientific Reports, 8: 4711.
  • [8] Ozturk Fincan G.S., Vural I.M., Yildirim S.S., Isli F., Dilekoz E., Ercan S., Sarioglu Y., (2016), Role of nicotinic acetylcholine receptor subtypes on nicotine's enhancing effect on electrical field stimulation elicited contractile responses in rabbit urine bladder, European Review for Medical and Pharmacological Sciences, 20(8): 1636-1641.
  • [9] Andersson, M., Aronsson, P., Doufish, D., Lampert, A., Tobin, G., (2012), Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder, Autonomic Neuroscience: Basic and Clinical, 170(1-2): 5-11.
  • [10] Darblade, B., Behr-Roussel, D., Oger, S., Hieble, J.P., Lebret, T., Gorny, D., Benoit, G., Alexandre, L., Giuliano, F., (2006), Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder, Urology, 68(2): 442-8.
  • [11] Giglio, D., Tobin, G., (2009), Muscarinic receptor subtypes in the lower urinary tract, Pharmacology, 83(5): 259-69.
  • [12] Hegde, S.S., Eglen, R.M., (1999), Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder, Life Sciences, 64(6-7): 419-28.
  • [13] Lüllmann, H., Hein, L., Mohr, K., Bieger, D., (2005), Color Atlas of Pharmacology, 3. Baskı, Thieme Publishers New York, s. 6, 7, 54.
  • [14] Brunton, L., Chabner, B., Knollman, B., (2010), Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12. Baskı, McGraw-Hill Higher Education, s. 214-320.
  • [15] Altinkurt, O., (1981), Farmakoloji I, Ankara Üniversitesi Basımevi, Ankara, s. 35, 105.
  • [16] Katzung, B.G., Masters, S.B., Trevor, A.J., (2012), Basic & Clinical Pharmacology, 12.Baskı, McGraw-Hill Higher Education, s. 87, 152.
  • [17] Kayaalp, S.O., (2002), Rasyonel Tedavi Yönünden Tıbbi Farmakoloji, 10.Baskı, Hacettepe-Taş, Ankara, s. 1093-1138.
  • [18] Guyton A.C. and Hall, J.E., (2013), Tıbbi Fizyoloji (çev. Yeğen, B.), 12. Baskı, Nobel Tıp Kitabevleri, s. 91, 307, 308, 731, 773.
  • [19] Thorneloe, K.S. and Nelson, M.T., (2005), Ion channels in smooth muscle: regulators of intracellular calcium and contractility, Canadian Journal of Physiology and Pharmacology, 83: 215–242.
  • [20] Bisset, D. and Chung, S.H., (2008), Efficacy of external tetraethylammonium block of the KcsA potassium channel: molecular and Brownian dynamics studies, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778(10): 2273-82.
  • [21] Gür, S., (1998), Mesane’nin Non-adrenerjik Non-kolinerjik Kontrolü, Ankara Eczacılık Fakültesi Dergisi, 27(1): 51-60.
  • [22] Vesela, R., Aronsson, P., Andersson, M., Wsol, V., Tobin, G., (2012), The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis/painful bladder syndrome, Journal of Physiology and Pharmacology, 63(3): 209-16.
  • [23] Daly, D.M., 1, Collins, V.M., Chapple, C.R., Grundy, D., (2011), The afferent system and its role in lower urinary tract dysfunction, Current Opinion in Urology, 21: 268–274.
  • [24] Gohar, O., (2005), The Transient Receptor Potential (TRP) Ion Channels, Modulator, 20: 20-23.
  • [25] Araki, I., Du, S., Kobayashi, H., Sawada, N., Mochizuki, T., Zakoji, H., Takeda, M., (2008), Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder, International Journal of Urology, 15(8): 681-687.
  • [26] Si, X., McManus, BM., Zhang, J., Yuan, J., Cheung, C., Esfandiarei, M., Suarez, A., Morgan, A., Luo, H., (2005), Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway, Journal of Virology, 79(13): 8014–8023.
  • [27] Xiang, N., Liu, J., Liao, Y., Huang, Y., Wu, Z., Bai, Z., Lin, X., Zhang, J., (2016), Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway, Scientific Reports, 6: 27583. 57
  • [28] Zhang, J., Jiang, W., Zuo, Z., (2014), Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor kappaB, Neuroscience, 261: 1-10.
  • [29] Ivan, A.L., Campanini, M.Z., Martinez, R.M., Ferreira, V.S., Steffen, V.S., Vicentini, F.T., Vilela, F.M., Martins, F.S., Zarpelon, A.C., Cunha, T.M., Fonseca, M.J., Baracat, A.A., Georgetti, S.R., Verri, W.A.Jr., Casagrande, R., (2014), Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro, Journal of Photochemistry and Photobiology B: Biology, 138: 124-33.
  • [30] İnan, O. A., (2015), Sıçan Mesane’si Düz Kası Kasılma-GevĢeme Yanıtları Üzerine Ammonium Pyrrolidine Dithiocarbamate, SG-Benz, Caffeic Acid Phenil Ester, Atorvastatin Kalsiyum’ un Etkileri, Yüksek Lisans Tezi, Dumlupınar Üniveristesi Fen Bilimleri Enstitüsü, Kütahya, s. 39.
  • [31] K Lanke, BM Krenn, W J G Melchers, J Seipelt and FJM van Kuppeveld, (2007), PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells, J Gen Virol. 88 (Pt 4): 1206-1217. doi: 10.1099 / vir.0.82634-0. PMID: 17374764 DOI: 10.1099 / vir.0.82634-0.
  • [32] Yanjie D., Qing Z., Laifang W., (2019), Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes, Chem Biol Interact., 306:131-137. doi: 10.1016 / j.cbi.2019.04.025. PMID: 31004595 DOI: 10.1016 / j.cbi.2019.04.025.
  • [33] Eun H. L., Seon K. S., Su R. S., (2017), Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction, Biochem Pharmacol.; 143:107-117. doi: 10.1016 / j.bcp.2017.07.011. PMID: 28712932 DOI: 10.1016 / j.bcp.2017.07.011 .
  • [34] Han, J.S., Kim, S.J., Nam, Y., Lee, H.Y., Kim, G.M., Kim, D.M., Sohn, U.D., (2019), The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat, Biomolecules & Therapeutics, 27 (1): 101-106.
  • [35] Hai Z., Daoda C., Jinghui Z., Yuan T., (2004), Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells, J Huazhong Univ Sci Technolog Med Sci.; 24 (2): 140-3, 157. doi: 10.1007 / BF02885413. PMID: 15315164 DOI: 10.1007 / BF02885413.
  • [36] Rembetski, B.E., Cobine, C.A., Drumm, B.T., (2018), Laboratory practical to study the differential innervation pathways of urinary tract smooth muscle, American Physiological Society, 1;42(2): 295-304.
  • [37] A Kondo, M Mogi, Y Koshihara, A Togari., (2001), Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells, Biochem Pharmacol.; 61(3):319-26. doi: 10.1016/s0006-2952(00)00544-x. PMID: 11172736 DOI: 10.1016/s0006-2952(00)00544-x.
  • [38] Rogers, M.J., Xiao, Z., Shen, B., Wang, J., Schwen, Z., Roppolo, J.R., de Groat, W.C., Tai, C., (2015), Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats, American Physiological Society, 1;308(1): R42-9.
  • [39] Hong F., Chounghun K., Jonathan R. D., Ryan K., Iwalola A., Yong Z., Li L. J., (2013), Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade, Exp Physiol.; 98 (3): 784-95. doi: 10.1113 / expphysiol.2012.069286. PMID: 23104933 DOI: 10.1113 / expphysiol.2012.069286.
  • [40] Zar, M.A., Iravani, M.M., Luheshi, G.N., (1990), Effect of nifedipine on the contractile responses of the isolated rat bladder, The Journal of Urology, 143(4): 835-9.
  • [41] Rud, T,. Andersson, K.E., Ulmsten, U., (1979), Effects of Nifedipine in Women with Unstable Bladders, Urologia Internationalis, 34: 421–429.
  • [42] Maggi, C.A., Manzini, S., Parlani, M., Conte, B., Giuliani, S., Meli, A., (1988), The effect of nifedipine on spontaneous, drug-induced and reflexly-activated contractions of the rat urinary bladder: evidence for the participation of an intracellular calcium store to micturition contraction, General Pharmacology: The Vascular System, 19(1): 73-81.
  • [43] Soichiro I., Shouji M., Kosuke O., Masataka I., Akihito I., Tomonori T., Nobuyuki E., Taishi Y., Masashi S., Hiroko D., Sachio M., Tomomi I., Hiroyuki T., (2019), Blockade of L-type Ca 2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway, Sci Rep.; 9(1):9850. doi: 10.1038 / s41598-019-46367-6. PMID: 31285514 PMCID: PMC6614470 DOI: 10.1038 / s41598-019-46367-6.
  • [44] Carpenter, F.G., (1978), Potentiation of nevre-induced bladder responses by tetraethylammonium in reletion to junctionaland extrajunctional muscarinic receptors, British journal of pharmacology, 64(3): 331-9.
  • [45] Oh, S.J., Ahn, S.C., (2003), Inhibitory effects of potassium channel blockers on carbachol induced contraction in rat detrusor muscle, Journal of Korean Medical Science, 18(5): 701-6.
There are 45 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Hayri Dayıoğlu This is me 0000-0002-9270-8561

Ayhan Yılmaz This is me 0000-0003-0410-8687

Aysun Erdoğan This is me 0000-0002-4738-8132

Fatih Alan This is me 0000-0002-0561-6192

Sinan Darcan This is me 0000-0002-2135-4807

Publication Date December 31, 2020
Submission Date April 20, 2020
Published in Issue Year 2020 Issue: 045

Cite

IEEE H. Dayıoğlu, A. Yılmaz, A. Erdoğan, F. Alan, and S. Darcan, “THE INVESTIGATION OF THE ACTION MECHANISM OF AMMONIUM PYRROLIDINE DITHIOCARBAMATE ON RAT BLADDER SMOOTH MUSCLE CONTRACTION-RELAXATION RESPONSES”, JSR-A, no. 045, pp. 28–49, December 2020.