MORPHOLOGICAL, HEMATOLOGICAL and HISTOPATHOLOGICAL EFFECTS of PROPYL PARABEN on ENDOCRINE GLANDS of MALE RATS at PREPUBERTAL PERIOD

Year 2022, Issue: 049, 74 - 91, 30.06.2022

Eda Nur İnkaya , Gözde Karabulut , Nurhayat Barlas

Abstract

Propyl paraben (propyl 4-Hydroxybenzoate) is frequently used in various products due to its physical and chemical properties and cheapness, and its use is increasing day by day due to the development of the industrial industry. This study is conducted on the side effects of propyl paraben on male rats' endocrine glands. Accordingly, each oil control, positive control (3 mg/kg/day flutamide=FLU), negative control (0.4 mg/kg/day testosterone propionate = TP) and 10, 250 and 750 mg/kg/day testosterone propionate + propyl paraben 6 groups were formed, one of which had six rats.

While a decrease was observed in thymus and spleen weights in the 10, 250 and 750 mg/kg/day testosterone propionate + propyl paraben dose groups compared to the fat control group, an increase was observed in the weight of the thyroid tissue in the 250 mg/kg/day testosterone propionate + propyl paraben dose group compared to the positive control and 10 mg/kg/day testosterone propionate + propyl paraben dose groups. It has also been shown with various damages in endocrine organs in histopathological examinations. Therefore, we can say that propyl paraben has a negative effect on the endocrine organs examined.

Keywords

Propyl paraben, Endocrine glands, Toxicity, Prepubertal male rats

Supporting Institution

Hacettepe University Scientific Research Projects Coordination Unit

Project Number

Project no: FHD-2017-13477

Thanks

Nurhayat BARLAS designed the study, analyzed the data, and reviewed the text. The text was written by Gözde KARABULUT, who also evaluated the data and updated it. Eda Nur İNKAYA gathered the information, analyzed it, and reviewed the paper. This work was reviewed and approved by all authors. We would like to express our gratitude to the writers for their dedication to this effort. The Hacettepe University Scientific Research Projects Coordination Unit provided financial assistance for this project (Project no: FHD-2017-13477). Eda Nur İNKAYA is supported by Council of Higher Education (YÖK), Turkey within the scope of YÖK 100/2000 PhD Scholarship.

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