Synthesis, characterization and biological studies of metal complexes of 4-iodo-n-(6-sulfamoylbenzothiazol-2-yl)benzamide

Year 2025, Issue: 061, 125 - 136, 30.06.2025

Halil İlkimen , Tuğçe Öztürk , Cengiz Yenikaya , Aysel Gülbandılar

Abstract

In this study, the new 4-iodo-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (L3) obtained from 2-amino-6-sulfamoylbenzothiazole (L1) and 4-iodobenzoyl chloride (L2) and Fe(II) {[Fe(L3)2(SO4)].H2O (1)}, Ni(II) {[Ni(L3)2(Ac)2].2H2O (2)} and Cu(II) {[Cu(L3)2(Ac)2].2H2O (3)} complexes were synthesized. The structures were synthesized by elemental analysis for L3 and 1-3, infrared spectroscopy (IR) for L3 and 1-3, nuclear magnetic resonance (NMR) for L3, atomic absorption spectroscopy (AAS), molar conductivity, and magnetic susceptibility methods for 1-3. As a consequence of spectroscopic evaluation, it was determined that compounds 1-3 exhibited a non-ionic and tetrahedral conformation. A comprehensive examination was conducted on the susceptibility of all substances to C. albicans (yeast), L. monocytogenes, E. faecalis, E. coli, P. aeruginosa, S. aureus, and B. subtilis (bacteria) were thoroughly investigated. The antimicrobial activities were contrasted with those of Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin, and Cefepime.

Keywords

2-Amino-6-sulfamoylbenzothiazole, 4-iodobenzoyl chloride, 4-iodo-N-(6-sulfamoylbenzothiazol-2-yl)benzamide, metal complex

Project Number

Kütahya Dumlupinar University Research Fund (Grant No. 2024/16).

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