The synthesis, characterization, and evaluation of the antimicrobial activity of the Co(II) complexes of 5-Sulfosalicylic acid and 2-Aminopyridine derivatives

Abstract

The new five Co(II) complexes {(HX)₂[Co(H₂O)₆](Hssa)₂.2H₂O (1), [Co(Hssa)(X)(H₂O)₂] (2), [Co(Hssa)(X)(H₂O)₂].H₂O (3), (HX)[Co(ssa)(H₂O)₄] (4), and (HX)[Co(ssa)(H₂O)₄] (5); H₃ssa: 5-sulfosalicylic acid, X = 2-amino-3-nitro-4-methylpyridine (L1) for 1, 2-amino-3-hydroxypyridine (L2) for 2, 2-amino-5-bromopyridine (L3) for 3, 2-amino-4-chloropyridine (L4) for 4 and 2,6-diaminopyridine (L5) for 5} were synthesized. The compounds 1-5 were characterized by FT-IR, thermal analyses, UV, magnetic susceptibility, and molar conductivity methods. All complexes (1-5) show an octahedral conformation. The structures 1, 4, and 5 have 3:2 ionic form for 1 and a 1:1 ionic form for 4 and 5, whereas the structures 2 and 3 have non-ionic forms. Also, Co(OH)₂, H₃ssa, and L1-L5 and 1-5 were screened for their antibacterial activity against Listeria monocytogenes, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and antifungal activity against Candida albicans microorganisms. The results emerge to be in accordance with those of the antifungal drug Ketoconazole and Fluconazole, and the antibacterial agents Chloramphenicol, Cefepime, Vancomycin, and Levofloxacin. The best activity MIC values were shown Co(OH)₂ and L5 for P. aeruginosa, Co(OH)₂, 3, and 5 for E. faecalis, L3 for B. subtilis, L5 for E. coli, L1, L2, L5, and 3 for L. monocytogenes, and L5, 2, and 5 for C. albicans. Compounds L2, L3, and 3 for B. subtilis bacteria, and compounds L5, 2, and 5 for C. albicans yeast had better activity than the control compounds.

Keywords

• 5-Sulfosalicylic acid
• 2-aminopyridine
• Co(II) complex
• antibacterial activity
• antifungal activity.

2-Aminopikolin Türevleri ile 4-Kloro-3-sülfamoyilbenzoik Asitin Cu(II) Komplekslerinin Sentezi, Karakterizasyonu, Antibakteriyel ve Antifungal Özelliklerinin İncelenmesiu

Abstract

Bazı yeni beş Co(II) kompleksi {(HX)2[Co(H2O)6](Hssa)2.2H2O (6), [Co(Hssa)(X)(H2O)2] (7), [Co(Hssa)(X)(H2O)2].H2O (8), (HX)[Co(ssa)(H2O)4] (9) ve (HX)[Co(ssa)(H2O)4] (10); 6 için X = 2-amino-3-nitro-4-metilpiridin (1), 7 için 2-amino-3-hidroksipiridin (2), 8 için 2-amino-5-bromopiridin (3), 9 için 2-amino-4-kloropiridin (4) ve 10 için 2,6-diaminopiridin (5)} sentezlendi. 6-10 bileşikleri FT-IR, termal analiz, UV, manyetik duyarlılık ve molar iletkenlik yöntemleri ile karakterize edildi. Tüm kompleksler (6-10) oktahedral konformasyon göstermektedir. 6, 9 ve 10 yapıları 6 için 3:2 iyonik forma ve 9 ve 10 için 1:1 iyonik forma sahipken, 7 ve 8 yapıları noniyonik formlara sahiptir. Ayrıca, Co(OH)2, H3ssa ve 1-10, Listeria monocytogenes, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis'e karşı antibakteriyel aktiviteleri ve Candida albicans mikroorganizmalarına karşı antifungal aktiviteleri açısından tarandı. Sonuçlar antifungal ilaçlar Ketokonazol ve Flukonazol ile antibakteriyel maddeler Kloramfenikol, Sefepim, Vankomisin ve Levofloksasin ile uyumlu çıkmıştır. En iyi aktivite MİK değerleri P. aeruginosa için Co(OH)2 ve 5, E. faecalis için Co(OH)2, 8 ve 10, B. subtilis için 3, E. coli için 5, L. monocytogenes için 1, 2, 5 ve 8 ve C. albicans için 5, 7 ve 10 olarak gösterilmiştir. B. subtilis bakterileri için 2, 3 ve 8 numaralı bileşikler ile C. albicans mayası için 5, 7 ve 10 numaralı bileşikler kontrol bileşiklerine göre daha iyi aktiviteye sahiptir.

Keywords

• 5-Sülfosalisilik asit
• 2-aminopiridin
• Co(II) kompleksi
• antibakteriyel aktivite
• antifungal aktivite.

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