Histopathologic and Immunohistochemical Approach to a Case of Invasive Cribriform Carcinoma in Mammary Tissue of Sprague Dawley Rat

Year 2024, Volume: 4 Issue: 1, 11 - 13, 30.06.2024

Metin Kiliçlioğlu , Berrah Gözegir , İsmail Bolat , Yavuz Sağlam , Serkan Yıldırım

https://doi.org/10.5281/zenodo.12577687

Abstract

Breast cancer is a neoplastic disease that originates in the breast tissue and can metastasize to other tissues and organs, especially the lung and liver. It is one of the most common cancers in dogs and cats, especially in humans. Breast cancers exhibit striking genetic and phenotypic diversity and have a highly complex mechanism. There are many subtypes of mammary cancer with different biological and pathologic features and different clinical course. In this case report; the mass detected in the abdominal region of the rat was removed under general anesthesia. The mass was examined macroscopically, histopathologically and immunohistochemically. As a result of the examinations, mammary tissue . Invasive Cribriform Carcinoma was diagnosed. In immunohistochemical analysis, Ki67 and α-SMA expressions were detected in the mass. In this case report, we contributed to the literature by determining the histopathologic findings of Invasive Cribriform Carcinoma in mammary tissue of rats and the expression levels of Ki67 and α-SMA in these carcinomas.

Keywords

Cancer, Histopathology, Immunohistochemistry Mammary, Rat

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