3-Hidroksibenzoik Asit – İzonikotinamid 1/1 Ko-Kristalinin Sentezi ve Spektroskopik Karakterizasyonu
Abstract
Bu çalışmada 3-hidroksibenzoik asit ile izonikotinamidin ko-kristali aseton-etanol çözeltisi içinde 1:1 oranında çözücü buharlaştırma yöntemi ile hazırlandı. Yapıları FT-IR, 1H NMR ve 13C NMR spektroskopileri, toz X ışını diffraksiyonu XRD ve diferansiyel tarama kalorimetresi DSC yöntemi ile karakterize edildi
References
- Akalin, E., Yilmaz, A., Akyuz, S. 2005. Vibrational analysis of isonicotinamide. J. Mol. Struct.,744-747:881-886.
- Arıcı, M., Yeşilel, OZ., Acar, E., Dege, N. 2017. Synthesis, cha- racterization and properties of nicotinamide and isonicotina- mide complexes with diverse dicarboxylic acids. Polyhedron., 127: 293–301.
- Ash, M., Ash, I. 2009. Handbook of preservatives. Synapse Information Resources, Endicott, NY .
- Bhardwaj, R.M., Yang, H., Florence, AJ. 2016. Crystal structure of the co-crystal butyl-paraben-isonicotinamide (1/1). Acta. Cryst. E. Crystallogr. Comm., 72: 53–55.
- Bond, AD. 2007. What is a co-crystal? Cryst. Eng. Comm., 9: 833–834.
- Vangala, VR., Chow, PS., Tan, RBH. 2011. Characterization, physicochemical and photo-stability of a co-crystal involving an antibiotic drug, nitrofurantoin, and 4-hydroxybenzoic acid. Cryst.Eng. Comm., 13: 759–762.
- Vishweshwar, P., Nangia, A., Lynch, VM. 2003. Supramolecular synthons in phenol–isonicotinamide adducts. Cryst. Eng. Comm., 5: 164–168.
- Vishweshwar, P., Thaimattam, R., Jaskólski, M., Desiraju, GR. 2002. Supramolecular synthons based on N-H...N and C-H...O hydrogen bonds. Crystal engineering of a helical structure with 5,5-diethylbarbituric acid. Chem. Commun., 7(17): 1830–1831.
- Vishweshwar, P., McMahon, JA., Peterson, ML., Hickey, MB., Shattock, TR., Zaworotko, MJ. 2005. Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients. Chem. Comm., 36: 4601-4603.
- Vijayalakshmi A, Vidyavathy B, Vinitha G. 2016. Crystal struc- ture, growth and nonlinear optical studies of isonicotinamide p-nitrophenol: A new organic crystal for optical limiting app- lications. J. Cryst. Growth., 448: 82–88.
- Wang, L., Zhao, L., Liu, W., Chen, R., Gu, Y., Yang, Y. 2012. Co- crystallization of glycine anhydride with the hydroxybenzoic acids: Controlled formation of dimers via synthons cooperation and structural characterization. Scı. Chına. Chem., 55: 2381– 2387.
- Yadav, AV., Shete, AS., Dabke, AP., Kulkarni, PV., Sakhare, SS. 2009. Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients. Indian J. Pharm. Sci., 71: 359–370.
Synthesis and Spectroscopic Characterization of 3-Hydroxybenzoic Acid -Isonicotinamide 1/1 Co-Crystalline
Abstract
The co-crystal of 3-hydroxybenzoic acid and the isonicotinamide were prepared by solvent evaporation in a 1: 1 ratio in acetoneethanol solution. Structures were characterized by FT-IR, 1 H NMR and 13C NMR spectroscopy, Powder X-ray diffraction XRD and differential scanning calorimetry DSC method.
References
- Akalin, E., Yilmaz, A., Akyuz, S. 2005. Vibrational analysis of isonicotinamide. J. Mol. Struct.,744-747:881-886.
- Arıcı, M., Yeşilel, OZ., Acar, E., Dege, N. 2017. Synthesis, cha- racterization and properties of nicotinamide and isonicotina- mide complexes with diverse dicarboxylic acids. Polyhedron., 127: 293–301.
- Ash, M., Ash, I. 2009. Handbook of preservatives. Synapse Information Resources, Endicott, NY .
- Bhardwaj, R.M., Yang, H., Florence, AJ. 2016. Crystal structure of the co-crystal butyl-paraben-isonicotinamide (1/1). Acta. Cryst. E. Crystallogr. Comm., 72: 53–55.
- Bond, AD. 2007. What is a co-crystal? Cryst. Eng. Comm., 9: 833–834.
- Vangala, VR., Chow, PS., Tan, RBH. 2011. Characterization, physicochemical and photo-stability of a co-crystal involving an antibiotic drug, nitrofurantoin, and 4-hydroxybenzoic acid. Cryst.Eng. Comm., 13: 759–762.
- Vishweshwar, P., Nangia, A., Lynch, VM. 2003. Supramolecular synthons in phenol–isonicotinamide adducts. Cryst. Eng. Comm., 5: 164–168.
- Vishweshwar, P., Thaimattam, R., Jaskólski, M., Desiraju, GR. 2002. Supramolecular synthons based on N-H...N and C-H...O hydrogen bonds. Crystal engineering of a helical structure with 5,5-diethylbarbituric acid. Chem. Commun., 7(17): 1830–1831.
- Vishweshwar, P., McMahon, JA., Peterson, ML., Hickey, MB., Shattock, TR., Zaworotko, MJ. 2005. Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients. Chem. Comm., 36: 4601-4603.
- Vijayalakshmi A, Vidyavathy B, Vinitha G. 2016. Crystal struc- ture, growth and nonlinear optical studies of isonicotinamide p-nitrophenol: A new organic crystal for optical limiting app- lications. J. Cryst. Growth., 448: 82–88.
- Wang, L., Zhao, L., Liu, W., Chen, R., Gu, Y., Yang, Y. 2012. Co- crystallization of glycine anhydride with the hydroxybenzoic acids: Controlled formation of dimers via synthons cooperation and structural characterization. Scı. Chına. Chem., 55: 2381– 2387.
- Yadav, AV., Shete, AS., Dabke, AP., Kulkarni, PV., Sakhare, SS. 2009. Co-crystals: a novel approach to modify physicochemical properties of active pharmaceutical ingredients. Indian J. Pharm. Sci., 71: 359–370.
There are 12 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 1, 2019 |
| Published in Issue | Year 2019 Volume: 9 Issue: 1 |