Antikanser Etkili Doğal Bir Bileşik: Bakteriyel Ekzopolisakkaritler

Yıl 2023, Cilt: 13 Sayı: 1, 217 - 223, 30.06.2023

Volkan Kuzucu , Nazime Dogan

Öz

Bakteriyel ekzopolisakkaritler (EPS'ler), birçok bakteri tarafından sentezlenen biyomoleküller olup çevresel koruma, yüzey yapışması ve hücresel etkileşimler gibi çeşitli biyolojik işlevlere sahiptir. Güçlü biyouyumlu özellikleri, onları çeşitli uygulamalara uygun hale getirmektedir. Kanser, dünyadaki en büyük hastalık yüklerinden biridir, bu nedenle kanser için yeni kemoterapötik etkili ajanlar ve tedaviler geliştirmek için çok sayıda bilimsel çalışma yürütülmektedir. Literatür bilgileri, EPS’lerin kanser hücrelerinin çoğalmasını, anjiyogenezisini ve metastazını engelleyebileceğini ve apoptozu uyarabileceğini göstermektedir. EPS’lerin meme, kolon, akciğer ve mide kanserine etkileri bilimsel çalışmalarla kanıtlanmıştır. Bu derleme, bakteriyel EPS’lerin antikanser özelliğini kısaca özetlemekte ve kemoterapi ve radyoterapinin yan etkilerini azaltabilecek bir ajan olarak potansiyel faydalarını vurgulayarak açıklamaktadır.

Anahtar Kelimeler

Antikanser etki, Bakteri, Ekzopolisakkarit

A Natural Compound with Anti-Cancer Effect: Bacterial Exopolysaccharides

Öz

Bacterial exopolysaccharides (EPSs) are biomolecules synthesized by many bacteria and have a variety of biological functions such as
environmental protection, surface adhesion, and cellular interactions. Their strong biocompatible properties make them suitable for
a variety of applications. As it is known, the disease burden of cancer is enormous both in terms of health and economy, therefore
numerous studies are being conducted to develop new chemotherapeutic agents and treatments for cancer by researchers. Literature
information indicates that EPSs can inhibit proliferation, angiogenesis and metastasis of cancer cells and stimulate apoptosis. The
effects of EPS on breast, colon, lung and stomach cancer have been proven by scientific studies. This review briefly summarizes
the anticancer properties of bacterial EPSs and highlights their potential benefits as an agent that can reduce the side effects of
chemotherapy and radiotherapy.

Anahtar Kelimeler

Anticancer effect, Bacteria, Exoplysaccharide

Kaynakça

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