Voltammetric Determination of Guaifenesin on Poly (Nile blue) Modified Glassy Carbon Electrode in Pharmaceutical Dosage Forms

Year 2018, Issue: 2, 27 - 31, 30.06.2018

Fatma Ağın

Abstract

The electro-oxidation behavior of expectorant
drug guaifenesin (GUF) was studied on poly(Nile blue) modified glassy carbon electrode
by cyclic voltammetry and differential pulse voltammetry. Camsı karbon elektrot
was modified with electropolymerization of Nile blue for sensitive
determination of GUF with voltammetric methods. The current peaks for GUF
occurred at around 1.130 V for differential pulse voltammetry when the
potential was scanned in the positive direction. The oxidation process of GUF
has shown irreversible and diffusion controlled behavior. The linear response
has been obtained in the range from 6 × 10^-7 to 1 × 10^-4 M with the limit of detection 1.24 × 10^-8 for
differential pulse voltammetry in 0.1 M phosphate buffer solution at pH 3.0.
Fully validated differential pulse voltammetry was successfully applied for the
determination of GUF from pharmaceutical dosage form and obtained satisfying
results.

Keywords

Guaifenesin, poly(Nile blue) modified glassy carbon electrode, voltammetry.

Guaifenesinin Poli(Nil Mavisi) ile Modifiye Edilmiş Camsı Karbon Elektrot ile Voltametrik Analizi ve Farmasötik Dozaj Formundan Tayini

Abstract

Ekspektorant bir ilaç etken maddesi guaifenesin (GUF)
elektro-oksidasyon davranışı poli(Nil mavisi) modifiye camsı karbon elektrotta
dönüşümlü voltametri (DV) ve diferansiyel puls voltametri (DPV) ile çalışıldı.
Camsı karbon elektrot, GUF’un voltametrik metodlarla hassas tayini için, Nil
mavisinin elektropolimerizasyonu ile modifiye edildi. Potansiyel pozitif yönde
tarandığında GUF’un pik akımı 1.130 V civarinda DPV ile oluştu. GUF’un
oksidasyon prosesi tersinmez ve difüzyon kontrollü davranış gösterdi. DPV için
doğrusal cevaplar                        
    6 × 10^-7- 1 × 10^-4 M, 1.24 × 10^-8 yakalama alt sınırı (YAS)
ile 0.1 M fosfat tamponu (FT) pH 3.0 içinde elde edildi. Tamamen valide edilmiş
DPV başarılı bir şekilde GUF’un farmasötik dozaj formundan miktar tayini için
uygulandı ve memnun edici sonuçlar elde edildi.

Keywords

Guafenesin, poli(Nil mavisi) modifiye camsı karbon elektrot, voltametri

References

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