Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo

İbrahim Etem Dural; Selçuk Kuzu; Çağlar Günebakan; Erkan Yıldız

Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo

Abstract

Introduction: The relationship between benign paroxysmal positional vertigo (BPPV) and cardiovascular autonomic dysfunction is not clear. Disruption of the balance between the sympathetic and parasympathetic systems causes various diseases. It is believed that disorders of the parasympathetic system, particularly, may be responsible for causing BPPV. Heart rate variability (HRV) and HRT (heart rate turbulence), which show autonomic dysfunction, are two non-invasive tests that show the relationship of the heart rate with the autonomic nervous system. The purpose of the present study was to evaluate the relationship between autonomic dysfunction and BPPV in patients with BPPV by using HRV and HRT, which are non-invasive laboratory parameters. Patients and Methods: A total of 100 age- and gender-matched volunteers and 100 patients with BPPV were selected for the study between January 2015 and January 2020. We obtained HRT and HRV parameters from 24-hour ECG Holter recordings. We considered a TO above 0 and a TS above 2.5 to be abnormal. We compared the parameters between groups. Results: A significant difference was observed between the BPPV and control groups in the HRV parameters SDNNI (p= 0.036), SDANN (p= 0.045), and HRT parameter TS (p= 0.048). We showed that abnormal TO (p= 0.025) and TS (p= 0.038) values were significantly higher in the patient group. Conclusion: Parasympathetic autonomic dysfunction was demonstrated by the lower HRV and HRT values observed in the patients with BPPV compared to the control group in the present study. The present findings must be confirmed with a much larger number of patients and multi-center studies.

Keywords

References

1. Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, et al. Clinical practice guideline: Benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg 2017;156(Suppl 3):1-47. [Crossref]
2. Tahtis V, Male A, Kaski D. Positional manoeuvres for BPPV: Theoretical approach to remote training for non-specialists. Front Neurol 2021;12. [Crossref]
3. Pappas DG. Autonomic related vertigo. Laryngoscope 2003;113:1658-71. [Crossref]
4. Yan H, Wang S, Cai H, Zhang J, Liu P, Wang Y, et al. Prognostic value of biomarkers in children and adolescents with orthostatic intolerance. Frontiers Pediatr 2021;9. [Crossref]
5. la Rovere MT, Maestri R, Pinna GD, Sleight P, Febo O. Clinical and haemodynamic correlates of heart rate turbulence as a non-invasive index of baroreflex sensitivity in chronic heart failure. Clinical Science 2011;121:279-84. [Crossref]
6. Thanou A, Stavrakis S, Dyer JW, Munroe ME, James JA, Merrill JT. Impact of heart rate variability, a marker for cardiac health, on lupus disease activity. Arthritis Res Ther 2016;18:1-10. [Crossref]
7. Lombardi F, Stein PK. Origin of heart rate variability and turbulence: An appraisal of autonomic modulation of cardiovascular function. Front Physiol 2011;2:95. [Crossref]
8. Billman GE, Huikuri H, Sacha J, Trimmel K. An introduction to heart rate variability: Methodological considerations and clinical applications. Front Physiol 2015;6:55. [Crossref]

9. Nakagawa H, Ohashi N, Kanda K, Watanabe Y. Autonomic nervous system disturbance as etiological background of vertigo and dizziness. Acta Otolaryngol Suppl 1993;504:130-3. [Crossref]
10. Staab JP, Ruckenstein MJ. Autonomic nervous system function in chronic dizziness. Otology Neurotol 2007;28:854-9. [Crossref]
11. Rabbitt RD. Semicircular canal biomechanics in health and disease. J Neurophysiol 2019;121:732-55. [Crossref]
12. Nuti D, Zee DS, Mandalà M. Benign paroxysmal positional vertigo: What we do and do not know. Seminars Neurol 2020;40:49-58. [Crossref]
13. Pezzoli M, Garzaro M, Pecorari G, Cena M, Giordano C, Albera R. Benign paroxysmal positional vertigo and orthostatic hypotension. Clin Auton Res 2010;20:27-31. [Crossref]
14. Kim HA, Lee H. Autonomic dysfunction as a possible cause of residual dizziness after successful treatment in benign paroxysmal positional vertigo. Clin Neurophysiol 2014;125:608-14. [Crossref]
15. Laborde S, Mosley E, Thayer JF. Heart rate variability and cardiac vagal tone in psychophysiological research - recommendations for experiment planning, data analysis, and data reporting. Front Psychol 2017;8:213. [Crossref]
16. Gökaslan S, Demirbaş H, Özer Gökaslan C. Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis. Turk J Med Sci 2020;50:442-7. [Crossref]
17. Szymanowska K, Piatkowska A, Nowicka A, Cofta S, Wierzchowiecki M. Heart rate turbulence in patients with obstructive sleep apnea syndrome. Cardiol J 2008;15(5):441-5.
18. Balcıoǧlu S, Arslan U, Türkoǧlu S, Özdemir M, Çengel A. Heart rate variability and heart rate turbulence in patients with type 2 diabetes mellitus with versus without cardiac autonomic neuropathy. Am J Cardiol 2007;100:890-3. [Crossref]

Details

Primary Language

English

Subjects

Cardiovascular Medicine and Haematology (Other)

Journal Section

Research Article

Authors

İbrahim Etem Dural ^* This is me
0000-0003-4005-4858
Türkiye

Selçuk Kuzu This is me
0000-0002-0511-9874
Türkiye

Çağlar Günebakan This is me
0000-0003-3281-9785
Türkiye

Erkan Yıldız This is me
0000-0002-0265-7327
Türkiye

Publication Date

July 12, 2023

Submission Date

July 6, 2022

Acceptance Date

April 25, 2023

Published in Issue

Year 2023 Volume: 26 Number: 2

IZ

https://izlik.org/JA76YZ47TA

Cite

RIS / Bibtex

APA

Dural, İ. E., Kuzu, S., Günebakan, Ç., & Yıldız, E. (2023). Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo. Koşuyolu Heart Journal, 26(2), 43-47. https://izlik.org/JA76YZ47TA

AMA

1.Dural İE, Kuzu S, Günebakan Ç, Yıldız E. Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo. Koşuyolu Heart Journal. 2023;26(2):43-47. https://izlik.org/JA76YZ47TA

Chicago

Dural, İbrahim Etem, Selçuk Kuzu, Çağlar Günebakan, and Erkan Yıldız. 2023. “Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients With Benign Paroxysmal Positional Vertigo”. Koşuyolu Heart Journal 26 (2): 43-47. https://izlik.org/JA76YZ47TA.

EndNote

Dural İE, Kuzu S, Günebakan Ç, Yıldız E (July 1, 2023) Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo. Koşuyolu Heart Journal 26 2 43–47.

IEEE

[1]İ. E. Dural, S. Kuzu, Ç. Günebakan, and E. Yıldız, “Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo”, Koşuyolu Heart Journal, vol. 26, no. 2, pp. 43–47, July 2023, [Online]. Available: https://izlik.org/JA76YZ47TA

ISNAD

Dural, İbrahim Etem - Kuzu, Selçuk - Günebakan, Çağlar - Yıldız, Erkan. “Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients With Benign Paroxysmal Positional Vertigo”. Koşuyolu Heart Journal 26/2 (July 1, 2023): 43-47. https://izlik.org/JA76YZ47TA.

JAMA

1.Dural İE, Kuzu S, Günebakan Ç, Yıldız E. Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo. Koşuyolu Heart Journal. 2023;26:43–47.

MLA

Dural, İbrahim Etem, et al. “Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients With Benign Paroxysmal Positional Vertigo”. Koşuyolu Heart Journal, vol. 26, no. 2, July 2023, pp. 43-47, https://izlik.org/JA76YZ47TA.

Vancouver

1.İbrahim Etem Dural, Selçuk Kuzu, Çağlar Günebakan, Erkan Yıldız. Evaluation of Cardiovascular Autonomic Dysfunction According to Heart Rate Turbulence and Variability in Patients with Benign Paroxysmal Positional Vertigo. Koşuyolu Heart Journal [Internet]. 2023 Jul. 1;26(2):43-7. Available from: https://izlik.org/JA76YZ47TA