The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment

Muhammed Bahadır Omar; Kenan Toprak; Khagani Isgandarov; Münevver Sarı; Elnur Alizade; Selçuk Pala

The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment

Abstract

Introduction: One of the pharmacological treatment options for improving the symptoms of peripheral artery disease (PAD) and increasing the quality of life is cilostazol. Cilostazol is a pharmacological agent that shows vasodilator activity mainly by reducing cAMP degradation through specific cellular phosphodiesterase 3A enzyme inhibition. The effect of cilostazol on electrocardiographic parameters is not clear. In this study, we aimed to examine the effect of cilostazol on electrocardiographic parameters in PAD patients. Patients and Methods: The study included a total of 32 patients diagnosed with intermittent claudication and peripheral artery disease (PAD), who were selected for medical treatment based on peripheral artery imaging. The subjects were started on 100 mg of cilostazol twice a day. The electrocardiographic measurements of the subjects before the cilostazol treatment and three months after the initiation of cilostazol were compared. Results: After a period of three months, statistically significant prolongation was observed in the ventricular repolarization parameters QTd, QTc, and Tpe of the subjects compared to their premedication values (p= 0.01, for all). Conclusion: It is known that patients with peripheral artery disease (PAD) are at an increased risk of major adverse cardiovascular events (MACE), including sudden cardiac death (SCD). In this context, close monitoring of electrocardiography markers for ventricular repolarization heterogeneity, such as QTd, QTc, and Tpe, is necessary when initiating cilostazol therapy in patients with peripheral artery disease (PAD). These markers may be closely associated with major adverse cardiovascular events (MACE), including sudden cardiac death (SCD), and therefore require careful monitoring in PAD patients receiving cilostazol treatment.

Keywords

References

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Details

Primary Language

English

Subjects

Cardiology

Journal Section

Research Article

Authors

Muhammed Bahadır Omar ^* This is me
0000-0002-7234-6321
Türkiye

Kenan Toprak This is me
0000-0001-8923-8709
Türkiye

Khagani Isgandarov This is me
0000-0001-8081-4319
Türkiye

Münevver Sarı This is me
0000-0003-2061-415X
Türkiye

Elnur Alizade This is me
0000-0001-6952-7386
Andorra

Selçuk Pala This is me
0000-0003-3523-1573
Türkiye

Publication Date

July 12, 2023

Submission Date

February 17, 2023

Acceptance Date

May 7, 2023

Published in Issue

Year 2023 Volume: 26 Number: 2

IZ

https://izlik.org/JA54WL45MG

Cite

RIS / Bibtex

APA

Omar, M. B., Toprak, K., Isgandarov, K., Sarı, M., Alizade, E., & Pala, S. (2023). The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment. Koşuyolu Heart Journal, 26(2), 70-75. https://izlik.org/JA54WL45MG

AMA

1.Omar MB, Toprak K, Isgandarov K, Sarı M, Alizade E, Pala S. The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment. Koşuyolu Heart Journal. 2023;26(2):70-75. https://izlik.org/JA54WL45MG

Chicago

Omar, Muhammed Bahadır, Kenan Toprak, Khagani Isgandarov, Münevver Sarı, Elnur Alizade, and Selçuk Pala. 2023. “The Effect of Cilostazol on Electrocardiographic Parameters in Patients With Peripheral Artery Disease Initiating Cilostazol Treatment”. Koşuyolu Heart Journal 26 (2): 70-75. https://izlik.org/JA54WL45MG.

EndNote

Omar MB, Toprak K, Isgandarov K, Sarı M, Alizade E, Pala S (July 1, 2023) The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment. Koşuyolu Heart Journal 26 2 70–75.

IEEE

[1]M. B. Omar, K. Toprak, K. Isgandarov, M. Sarı, E. Alizade, and S. Pala, “The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment”, Koşuyolu Heart Journal, vol. 26, no. 2, pp. 70–75, July 2023, [Online]. Available: https://izlik.org/JA54WL45MG

ISNAD

Omar, Muhammed Bahadır - Toprak, Kenan - Isgandarov, Khagani - Sarı, Münevver - Alizade, Elnur - Pala, Selçuk. “The Effect of Cilostazol on Electrocardiographic Parameters in Patients With Peripheral Artery Disease Initiating Cilostazol Treatment”. Koşuyolu Heart Journal 26/2 (July 1, 2023): 70-75. https://izlik.org/JA54WL45MG.

JAMA

1.Omar MB, Toprak K, Isgandarov K, Sarı M, Alizade E, Pala S. The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment. Koşuyolu Heart Journal. 2023;26:70–75.

MLA

Omar, Muhammed Bahadır, et al. “The Effect of Cilostazol on Electrocardiographic Parameters in Patients With Peripheral Artery Disease Initiating Cilostazol Treatment”. Koşuyolu Heart Journal, vol. 26, no. 2, July 2023, pp. 70-75, https://izlik.org/JA54WL45MG.

Vancouver

1.Muhammed Bahadır Omar, Kenan Toprak, Khagani Isgandarov, Münevver Sarı, Elnur Alizade, Selçuk Pala. The Effect of Cilostazol on Electrocardiographic Parameters in Patients with Peripheral Artery Disease Initiating Cilostazol Treatment. Koşuyolu Heart Journal [Internet]. 2023 Jul. 1;26(2):70-5. Available from: https://izlik.org/JA54WL45MG