Beyond the Lipid-lowering Effects of Statins: Renal Effects

Abstract

Nowadays statins, 3 hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase enzyme inhibitors, are used in the treatment of hyperlipidemia. Statins have been shown to decrease cardiovascular mortality and morbidity in both coronary artery disease and peripheral arterial disease. Besides their lipid-lowering effects, statins have pleiotropic effects such as improvement of endothelial dysfunction, atherosclerotic plaques stabilization, oxidative stress inhibition, anti-inflammatory, and antithrombogenic effects. Some clinical trials have revealed that statin therapy improved renal function. On the other hand, statins have been shown to have no beneficial effects in many studies in renal function. In this review, we aimed to evaluate the effects of statins on renal function.

Keywords

• Statin,chronic renal disease,acute renal disease,contrast-induced nephropathy

Statinlerin Lipit Düşürücü Etkilerinin Ötesi: Renal Etkileri

Abstract

Statin 3-hidroksi-3-metilglutaril CoA (HMG CoA) redüktaz enzim inhibitörü olarak günümüzde hiperlipidemi tedavisinde yaygın olarak kullanılmaktadır. Özellikle koroner arter hastalığı ve periferik arter hastalığında morbidite ve mortaliteyi azalttığı gösterilmiştir. Aynı zamanda aterosklerotik plak stabilizasyonu, endotel fonksiyonunu iyileştirme, oksidatif stres, inflamasyon ve tromboza yanıtın inhibisyonu gibi pleiotropik etkileri de bulunmaktadır. Statinin kanıtlanmış birçok yararlı etkisinin olmasının yanında, özellikle böbrek fonksiyonları üzerine etkisiyle ilgili çalışmalarda çelişkili sonuçlar bulunmaktadır. Bazı klinik çalışmalarda statinin böbrek fonksiyonları üzerine faydalı olduğu saptanmışken, birçok çalışmada da faydalı etkisinin olmadığı gösterilmiştir. Biz bu derlemede statin ile akut, kronik ve kontrasta bağlı nefropati ilişkilerini araştıran çalışmaları inceleyerek, statinin böbrek fonksiyonları üzerine etkisini değerlendirmeye çalıştık.

Keywords

• Statin,kronik böbrek yetersizliği,akut böbrek yetersizliği,kontrast nefropati

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