Kararlı Anjina Pektorisli Hastalarda Trimetazidin Tedavisinin Lipoprotein İlişkili Fosfolipaz A2 Düzeyi ve Egzersiz Parametreleri Üzerine Etkisi

Abstract

Giriş: Kararlı anjina pektorisli hastalarda, metabolik bir anti-iskemik ilaç olan trimetazidin (TMZ) tedavisinin risk faktörü olarak kabul edilen lipoprotein ilişkili fosfolipaz A₂ (Lp-PLA₂) düzeyi ve egzersiz parametreleri üzerine etkisi araştırıldı.

Hastalar ve Yöntem: Egzersiz testi pozitif olan kararlı anjina pektorisli 30 hasta (ort. yaş 62.1 ± 8.3; dağılım 47-77) çalışmaya alındı. Trimetazidin tedavisi öncesinde Lp-PLA₂ düzeyleri ölçüldü; 12 haftalık TMZ tedavisi sonrasında egzersiz testi ve Lp-PLA₂ ölçümleri tekrarlandı.

Bulgular: Trimetazidin tedavisi sonrasında Lp-PLA₂ düzeyleri anlamlı düşüş (p= 0.006), egzersiz iş yükü anlamlı artış (p= 0.048) gösterdi.

Sonuç: Trimetazidin tedavisi kardiyak metabolizma değişikliği sonucu serbest oksijen radikal oluşumunu ve enflamasyonu azaltarak Lp-PLA₂ düzeyinde anlamlı düşüş sağlamaktadır. Bu bulgu, egzersiz parametrelerindeki iyileşmelerle birlikte, TMZ tedavisinin kararlı anjina pektorisli hastaların prognozunda olumlu katkı sağlayabileceğini göstermektedir.

Keywords

• Anjina,kararlı,trimetazidin,lipoprotein ilişkili fosfolipaz A2

Effects of Trimetazidine Treatment on the Lipoprotein-Associated Phospholipase A2 Level and Exercise Parameters in Patients with Stable Angina Pectoris

Abstract

Introduction: We examined the clinical effectiveness of trimetazidine (TMZ), a metabolic anti-ischemic agent, on lipoprotein-associated phospholipase A₂ (Lp-PLA₂) levels, which is considered a risk factor for cardiovascular events, and on exercise parameters in patients with stable angina pectoris (SAP).

Patients and Methods: The study included 30 patients (mean age 62.1 ± 8.3 years; range 47 to 77 years) with SAP and a positive exercise test result. Serum Lp-PLA₂ levels were measured at baseline. Exercise testing and Lp-PLA₂ measurements were repeated after at least 12 weeks of TMZ treatment.

Results: After TMZ treatment, Lp-PLA₂ levels decreased significantly (p= 0.006), and workload increased significantly (p= 0.048).

Conclusion: Trimetazidine treatment reduces serum Lp-PLA₂ levels via shifting cardiac metabolism, resulting in decreased production of free oxygen radicals and inflammation. This finding, together with improvements in exercise test parameters, suggests that TMZ may have a beneficial effect on the prognosis of patients with SAP.

Keywords

• Angina,stable,trimetazidine,lipoprotein-associated phospholipase A2

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