Research Article
BibTex RIS Cite

Repair of Complex Mitral Valve Pathologies: Is It Worth to Cope With?

Year 2018, Volume: 21 Issue: 1, 32 - 38, 01.04.2018

Abstract

Introduction:
Mitral
valve (MV) repair is preferred over replacement for its benefits of
preservation of ventricular function, lower operative mortality, superior
long-term survival, and avoidance of anticoagulation. In this study, we aimed
to review the repair techniques of complex MV pathologies and their outcomes.



Patients
and Methods:
We retrospectively analyzed 56 patients (mean age 41.8 ±
16.5 years; 33 males) who underwent repair of complex MV pathologies. 44
patients had pure mitral regurgitation (MR), and 12 (21.4%) had mixed mitral
disease (mitral stenosis (MS) + MR). Preoperative and operative
characteristics, postoperative MR severity, operative mortality, and midterm
survival were examined for each patient.



Results: There was
only one early death (30-day mortality: 1.8%) due to postoperative low cardiac
output syndrome. The procedures were successful in all patients who underwent
MV repair. Transthoracic echocardiography examinations revealed no/trivial MR
in 74.6% and mild MR in 21.8% of patients at discharge. Late follow-up was
obtained in 55 patients. The mean follow-up period of patients was 47.9 ± 23.1
months. Mortality developed in one (1.8%) patient with Marfan syndrome who had
acute aortic dissection three years after MV surgery. During follow-up visits,
mitral repair procedures were successful in 49 (90.7%) patients. Four (7.4%)
patients presented with moderate MR. Only one (1.9%) patient needed reoperation
because of severe MR.



Conclusion: This study showed that
repair of complex MV pathologies provides excellent surgical outcomes. Repair
of complex MV pathologies is safe and highly effective, but operations require
considerable surgical experience.

References

  • 1. Ren JF, Askut S, Lightly GW Jr, Vigilante GJ, Sink JD, Segal BL, et al. Mitral valve repair is superior to valve replacement for early preservation of cardiac function: relation of ventricular geometry to function. Am Heart J 1996;131:974-81.
  • 2. Suri RM, Schaff HV, Dearani JA, Sundt TM 3rd, Daly RC, Mullany CJ, et al. Survival advantage and improved durability of mitral repair for leaflet prolapse subsets in the current era. Ann Thorac Surg 2006;82:819-26.
  • 3. Enriquez-Sarano M, Schaff HV, Orszulak TA, Tajik AJ, Bailey KR, Frye RL. Valve repair improves the outcome of surgery for mitral regurgitation. A multivariate analysis. Circulation 1995;91:1022-8.
  • 4. David TE, Armstrong S, Sun Z, Daniel L. Late results of mitral valve repair for mitral regurgitation due to degenerative disease. Ann Thorac Surg 1993;56:7-12; discussion 13-4.
  • 5. Gillinov AM, Cosgrove DM, Blackstone EH, Diaz R, Arnold JH, Lytle BW, et al. Durability of mitral valve repair for degenerative disease. J Thorac Cardiovasc Surg 1998;116:734-43.
  • 6. Korkmaz AA, Onan B, Demir AS, Tarakçı S, Gündoğdu R, Akdemir I, et al. Clinical outcomes of mitral valve repair in mitral regurgitation: a prospective analysis of 100 consecutive patients. Anadolu Kardiol Derg 2011;11:542-50.
  • 7. Onan B, Erkanlı K, Onan IS, Ersoy B, Aktürk IF, Bakır I. Clinical outcomes of mitral valve repair, a single center experience in 100 patients. Türk Kalp Damar Cerrahisi Dergisi 2014;22:19-28.
  • 8. Cosgrove DM, Steward WJ. Mitral valvuloplasty. Current Probl Cardiol 1989;14:359-415.
  • 9. Yau TM, Ei-Ghoneimi YA, Armstrong S, Ivanov J, David TE. Mitral valve repair and replacement in rheumatic disease. J Thorac Cardiovasc Surg 2000;119:53-60.
  • 10. David TE, Ivanov J, Armstrong S, Christie D, Rakowski H. A comparison of outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse. J Thorac Cardiovasc Surg 2005;130:1242-9.
  • 11. Carpentier A. Cardiac valve surgery-the “French correction”. J Thorac Cardiovasc Surg 1983;86:323-37.
  • 12. Duran CG, Revuelta JM, Gaite L, Alonso C, Fleitas MG. Stability of mitral reconstruction surgery at 10-12 years for predominantly rheumatic valvular disease. Circulation 1988;78:91-6.
  • 13. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, et al. Guidelines on the management of valvular heart disease. The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg 2012;42:S1-44.
  • 14. Bonow RO, Carabello BA, Chaterjee K, de Leon AC, Faxon DP, Freed MD, et al. Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2008;118:e523-661.
  • 15. Adams DH, Anyanwu AC, Rahmanian PB, Filsoufi F. Current concepts in mitral valve repair for degenerative disease. Heart Fail Rev 2006;11: 241-57.
  • 16. Kumar AS, Rao PN, Saxena A. Results of mitral valve reconstruction in children with rheumatic heart disease. Ann Thorac Surg 1995;60:1044-7.
  • 17. Erez E, Kanter KR, Isom E, Williams WH, Tam VK. Mitral valve replacement in children. J Heart Valve Dis 2003;12:25-9.
  • 18. Gao G, Wu Y, Grunkemeier GL, Furnary AP, Starr A. Forty-years survival with the Starr-Edwards heart valve prosthesis. J Heart Valve Dis 2004;13:91-6.
  • 19. Braunberger E, Deloche A, Berrebi A, Abdallah F, Celestin JA, Meimoun P, et al. Very long-term results (more than 20 years) of valve repair with Carpentier’s techniques in nonrheumatic mitral valve insufficiency. Circulation 2001;104:8-11.
  • 20. Gillinov AM, Blackstone EH, Alaulaqi A, Sabik JF, Mihaljevic T, Svensson LG, et al. Outcomes after repair of the anterior mitral leaflet for degenerative disease. Ann Thorac Surg 2008;86:708-17.
  • 21. Kasegawa H, Shimokawa T, Shibazaki I, Koyanagi T, Ida T. Mitral valve repair for anterior leaflet prolapse with expanded polytetrafluoroethylene sutures. Ann Thorac Surg 2006;81:1625-31.
  • 22. Chauvaud S, Jebara V, Chachques JC, El Asmar B, Mihaileanu S, Perier P, et al. Valve extension with glutaraldehyde-preserved autologous pericardium: results inmitral valve repair. J Thorac Cardiovasc Surg 1991;102:171-8.
  • 23. Chauvaud S, Fuzellier JF, Berrebi A, Deloche A, Fabiani JN, Carpentier A. Long term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. Circulation 2001;104(Suppl I):I-12-5.
  • 24. Zakkar M, Amirak E, John Chan KM, Punjabi PP. Rheumatic mitral valve disease: current surgical status. Prog Cardiovasc Dis 2009;51:478-81.
  • 25. Dillon J, Yakub MA, Nordin MN, Pau KK, Krishna Moorthy PS. Leaflet extension in rheumatic mitral valve reconstruction. Eur J Cardiothorac Surg 2013;44:682-9.
  • 26. Kadoba K, Jonas RA, Mayer JE, Castaneda AR. Mitral valve replacement in the first year of life. J Thorac Cardiovasc Surg 1990;100:762-8.
  • 27. Carpentier A, Branchini B, Cour JC, Asfaou E, Villani M, Deloche A, et al. Congenital malformations of the mitral valve in children. Pathology and surgical treatment. J Thorac Cardiovasc Surg 1976;72:854-8.
  • 28. Murakami T, Yagihara T, Yamamoto F, Uemura H, Yamashita K, Ishizaka T. Artificial chordae for mitral valve reconstruction in children. Ann Thorac Surg 1998;65:1377-80.
  • 29. Kawahira Y, Yagihara T, Uemura H, Ishizaka H, Yoshizumi K, Kitamura S.Use of expanded polytetrafluoroethylene sutures as artificial tendinous cords in children with congenital mitral regurgitation. European Journal of Cardio-thoracic Surgery 1999:15:289-293.
  • 30. Okita Y, Miki S, Kusuhara K, Ueda Y, Tahata T, Tsukamoto Y, et al. Early and late results of reconstructive operation for congenital mitral regurgitation in pediatric age group. The Journal of Thoracic and Cardiovascular Surgery 1988;96:294-8.
  • 31. Grigg LE, Wigle ED, Williams WG, Daniel LB, Rakowski H. Transesophageal Doppler echocardiography in obstructive hypertrophic cardiomyopathy: clarification of pathophysiology and importance in intraoperative decision making. J Am Coll Cardiol 1992;20:42-52.
  • 32. Van der Lee C, Kofflard MJM, van Herwerden LA, Vletter WB, ten Cate FJ. et al. Sustained improvement after combined anterior mitral leaflet extension and myectomy in hypertrophic obstructive cardiomyopathy. Circulation 2003;108:2088-92.

Kompleks Mitral Kapak Patolojilerin Onarımı; Uğraşmaya Değer mi?

Year 2018, Volume: 21 Issue: 1, 32 - 38, 01.04.2018

Abstract

Giriş: Ventrikül fonksiyonun korunması, daha az cerrahi mortaliteye sahip olması,
üstün uzun dönem survey ve antikoagülan kullanımının önlenmesi gibi
üstünlükleri nedeniyle mitral kapak onarımı replasmana daha çok tercih
edilmektedir. Bu çalışmanın amacı, kompleks mitral kapak patolojilerin onarım
teknikleri ve sonuçları sunmaktır.



Hastalar ve
Yöntem:
Retrospektif olarak kompleks mitral kapak patolojilerin
onarımı geçiren 56 hasta incelendi (ortalama yaş 41.8 ± 16.5 yıl; 33 erkek).
Kırk dört hastada saf mitral yetmezliği varken, 12 (%21.4) hastada miks mitral
kapak hastalığı (mitral darlığı + mitral yetmezliği) vardı. Preoperatif ve
operatif özellikleri, postoperatif mitral yetmezliği derecesi, cerrahi
mortalite ve orta dönem sonuçları her hasta için araştırıldı.



Bulgular: Postoperatif düşük kardiyak debi sendromuna bağlı bir hastada erken
mortalite (30 gün mortalite: %1.8) görüldü. Mitral kapak onarımı ameliyatı olan
bütün hastalarda mitral onarım prosedürleri başarılı olmuştur. Hastalar taburcu
olduğunda yapılan ekokardiyografik değerlendirmede %74.6’sında hiç/eser
yetersizlik ve %21.8’inde hafif yetersizlik saptandı. 55 hastada geç dönem
takibi yapıldı. Hastalarımızın ortalama takip süresi 47.9 ± 23.1 aydı. Geç
mortalite mitral kapak onarımından 3 yıl sonra akut aort diseksiyonu nedeniyle
ameliyata alınan marfan sendromlu bir hastada gözlendi. Takipler sırasında
yapılan ekokardiyografik değerlendirmede hastaların %90.7 (49 hasta)’sinde  hiç ya da hafif yetersizlik gözlendi. Orta
yetersizlik gözlenen 4 (%7.4) hastada tıbbi tedavi uygulandı. İleri yetersizlik
gözlenen 1 (%1.9) hastada reoperasyon uygulandı.



Sonuç: Çalışmamız kompleks mitral
kapak patolojilerin onarımının sonuçları mükemmel olduğunu gösterdi. Kompleks
mitral kapak patolojilerin onarım teknikleri güvenli ve sonuçları son derece
etkindir, fakat ameliyatlarda yeterli cerrahi tecrübe gereklidir.

References

  • 1. Ren JF, Askut S, Lightly GW Jr, Vigilante GJ, Sink JD, Segal BL, et al. Mitral valve repair is superior to valve replacement for early preservation of cardiac function: relation of ventricular geometry to function. Am Heart J 1996;131:974-81.
  • 2. Suri RM, Schaff HV, Dearani JA, Sundt TM 3rd, Daly RC, Mullany CJ, et al. Survival advantage and improved durability of mitral repair for leaflet prolapse subsets in the current era. Ann Thorac Surg 2006;82:819-26.
  • 3. Enriquez-Sarano M, Schaff HV, Orszulak TA, Tajik AJ, Bailey KR, Frye RL. Valve repair improves the outcome of surgery for mitral regurgitation. A multivariate analysis. Circulation 1995;91:1022-8.
  • 4. David TE, Armstrong S, Sun Z, Daniel L. Late results of mitral valve repair for mitral regurgitation due to degenerative disease. Ann Thorac Surg 1993;56:7-12; discussion 13-4.
  • 5. Gillinov AM, Cosgrove DM, Blackstone EH, Diaz R, Arnold JH, Lytle BW, et al. Durability of mitral valve repair for degenerative disease. J Thorac Cardiovasc Surg 1998;116:734-43.
  • 6. Korkmaz AA, Onan B, Demir AS, Tarakçı S, Gündoğdu R, Akdemir I, et al. Clinical outcomes of mitral valve repair in mitral regurgitation: a prospective analysis of 100 consecutive patients. Anadolu Kardiol Derg 2011;11:542-50.
  • 7. Onan B, Erkanlı K, Onan IS, Ersoy B, Aktürk IF, Bakır I. Clinical outcomes of mitral valve repair, a single center experience in 100 patients. Türk Kalp Damar Cerrahisi Dergisi 2014;22:19-28.
  • 8. Cosgrove DM, Steward WJ. Mitral valvuloplasty. Current Probl Cardiol 1989;14:359-415.
  • 9. Yau TM, Ei-Ghoneimi YA, Armstrong S, Ivanov J, David TE. Mitral valve repair and replacement in rheumatic disease. J Thorac Cardiovasc Surg 2000;119:53-60.
  • 10. David TE, Ivanov J, Armstrong S, Christie D, Rakowski H. A comparison of outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse. J Thorac Cardiovasc Surg 2005;130:1242-9.
  • 11. Carpentier A. Cardiac valve surgery-the “French correction”. J Thorac Cardiovasc Surg 1983;86:323-37.
  • 12. Duran CG, Revuelta JM, Gaite L, Alonso C, Fleitas MG. Stability of mitral reconstruction surgery at 10-12 years for predominantly rheumatic valvular disease. Circulation 1988;78:91-6.
  • 13. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, et al. Guidelines on the management of valvular heart disease. The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg 2012;42:S1-44.
  • 14. Bonow RO, Carabello BA, Chaterjee K, de Leon AC, Faxon DP, Freed MD, et al. Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2008;118:e523-661.
  • 15. Adams DH, Anyanwu AC, Rahmanian PB, Filsoufi F. Current concepts in mitral valve repair for degenerative disease. Heart Fail Rev 2006;11: 241-57.
  • 16. Kumar AS, Rao PN, Saxena A. Results of mitral valve reconstruction in children with rheumatic heart disease. Ann Thorac Surg 1995;60:1044-7.
  • 17. Erez E, Kanter KR, Isom E, Williams WH, Tam VK. Mitral valve replacement in children. J Heart Valve Dis 2003;12:25-9.
  • 18. Gao G, Wu Y, Grunkemeier GL, Furnary AP, Starr A. Forty-years survival with the Starr-Edwards heart valve prosthesis. J Heart Valve Dis 2004;13:91-6.
  • 19. Braunberger E, Deloche A, Berrebi A, Abdallah F, Celestin JA, Meimoun P, et al. Very long-term results (more than 20 years) of valve repair with Carpentier’s techniques in nonrheumatic mitral valve insufficiency. Circulation 2001;104:8-11.
  • 20. Gillinov AM, Blackstone EH, Alaulaqi A, Sabik JF, Mihaljevic T, Svensson LG, et al. Outcomes after repair of the anterior mitral leaflet for degenerative disease. Ann Thorac Surg 2008;86:708-17.
  • 21. Kasegawa H, Shimokawa T, Shibazaki I, Koyanagi T, Ida T. Mitral valve repair for anterior leaflet prolapse with expanded polytetrafluoroethylene sutures. Ann Thorac Surg 2006;81:1625-31.
  • 22. Chauvaud S, Jebara V, Chachques JC, El Asmar B, Mihaileanu S, Perier P, et al. Valve extension with glutaraldehyde-preserved autologous pericardium: results inmitral valve repair. J Thorac Cardiovasc Surg 1991;102:171-8.
  • 23. Chauvaud S, Fuzellier JF, Berrebi A, Deloche A, Fabiani JN, Carpentier A. Long term (29 years) results of reconstructive surgery in rheumatic mitral valve insufficiency. Circulation 2001;104(Suppl I):I-12-5.
  • 24. Zakkar M, Amirak E, John Chan KM, Punjabi PP. Rheumatic mitral valve disease: current surgical status. Prog Cardiovasc Dis 2009;51:478-81.
  • 25. Dillon J, Yakub MA, Nordin MN, Pau KK, Krishna Moorthy PS. Leaflet extension in rheumatic mitral valve reconstruction. Eur J Cardiothorac Surg 2013;44:682-9.
  • 26. Kadoba K, Jonas RA, Mayer JE, Castaneda AR. Mitral valve replacement in the first year of life. J Thorac Cardiovasc Surg 1990;100:762-8.
  • 27. Carpentier A, Branchini B, Cour JC, Asfaou E, Villani M, Deloche A, et al. Congenital malformations of the mitral valve in children. Pathology and surgical treatment. J Thorac Cardiovasc Surg 1976;72:854-8.
  • 28. Murakami T, Yagihara T, Yamamoto F, Uemura H, Yamashita K, Ishizaka T. Artificial chordae for mitral valve reconstruction in children. Ann Thorac Surg 1998;65:1377-80.
  • 29. Kawahira Y, Yagihara T, Uemura H, Ishizaka H, Yoshizumi K, Kitamura S.Use of expanded polytetrafluoroethylene sutures as artificial tendinous cords in children with congenital mitral regurgitation. European Journal of Cardio-thoracic Surgery 1999:15:289-293.
  • 30. Okita Y, Miki S, Kusuhara K, Ueda Y, Tahata T, Tsukamoto Y, et al. Early and late results of reconstructive operation for congenital mitral regurgitation in pediatric age group. The Journal of Thoracic and Cardiovascular Surgery 1988;96:294-8.
  • 31. Grigg LE, Wigle ED, Williams WG, Daniel LB, Rakowski H. Transesophageal Doppler echocardiography in obstructive hypertrophic cardiomyopathy: clarification of pathophysiology and importance in intraoperative decision making. J Am Coll Cardiol 1992;20:42-52.
  • 32. Van der Lee C, Kofflard MJM, van Herwerden LA, Vletter WB, ten Cate FJ. et al. Sustained improvement after combined anterior mitral leaflet extension and myectomy in hypertrophic obstructive cardiomyopathy. Circulation 2003;108:2088-92.
There are 32 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Investigations
Authors

Salih Salihi This is me

H. Tarık Kızıltan This is me

Aşkın Ali Korkmaz This is me

Mustafa Güden This is me

Publication Date April 1, 2018
Published in Issue Year 2018 Volume: 21 Issue: 1

Cite

Vancouver Salihi S, Kızıltan HT, Korkmaz AA, Güden M. Repair of Complex Mitral Valve Pathologies: Is It Worth to Cope With?. Koşuyolu Heart Journal. 2018;21(1):32-8.