Copeptin Level in Isolated Coronary Artery Ectasia

Year 2018, Volume: 21 Issue: 2, 117 - 121, 19.08.2018

Osman Bektaş , Diyar Köprülü Sezgin Albayrak Adil Bayramoğlu Zeki Yüksel Günaydın Mehmet Yaman Ahmet Kaya

Abstract

Introduction:
The
level of copeptin was investigated in patients who underwent coronary
angiography for suspected coronary artery disease and diagnosed with isolated
coronary artery ectasia (CAE).

Patients
and Methods: A total of 308 patients were diagnosed as having coronary
ectasia out of 3412 patients who underwent coronary angiography between May
2015 and July 2016. The evaluations were performed by two experienced
physicians who were aware of the study design. Among these patients, 41
patients who did not have severe coronary artery disease (CAD) and who were
diagnosed as having isolated CAE were included in the study. The control group
comprised 33 age- and gender-matched individuals diagnosed as having normal
coronary arteries following coronary angiography for suspected CAD. Patients
with a previous coronary revascularization for severe CAD, known congestive
heart disease and severe cardiac valve disease, and a left ventricular ejection
fraction below 50% were excluded from the study. Blood samples were obtained
from both groups and the serum copeptin levels were compared with each other.

Results: Among
patients with CAE, the frequency of isolated CAE was 14.9%. Among the total
coronary angiography series, the frequency of isolated CAE was 1.34%. Most patients
with isolated CAE were men (70%; women: 30%), and the mean age of the patients
was 58 ± 9.2 years. In patients with isolated CAE, the frequencies of type I,
type II, type III, and type IV CAE were found to be 4.3%, 17.4%, 32.6%, and
45.6%, respectively, according to Markis classification. The level of copeptin
was found to be 7.8 ± 0.9 pmol/L in patients with normal coronary arteries and
9.7 ± 1.6 pmol/L in patients with isolated CAE (p< 0.028).

Conclusion: The level of copeptin is
increased in patients with isolated CAE. However, our results have to be
supported by long-term randomized studies on isolated CAE patients with and
high copeptin levels.

Keywords

Isolated coronary ectasia, copeptin

İzole Koroner Ektazide Kopeptin Düzeyi

Abstract

Giriş: Bu çalışmada koroner arter hastalığı şüphesiyle
koroner anjiyografi yapılan ve izole koroner ektazi saptanan hastalarda
kopeptin düzeyi araştırıldı.

Hastalar ve Yöntem: Merkezimizde Mayıs 2015-Temmuz 2016
tarihleri arasında koroner anjiyografi uygulanan 3412 hastada, en az iki
bağımsız operatörün değerlendirilmesi sonucunda 308 koroner arter ektazi (KAE)
olgusu saptandı. Bu hastalardan ciddi koroner arter hastalığı (KAH)
olmayan  izole KAE’si olan 41 hasta
çalışmaya alındı. Kontrol grubu, KAH şüphesiyle koroner anjiyografisi yapılıp
normal koroner arter saptanan yaş ve cinsiyet olarak uyumlu 33 bireyden
oluşturuldu. Daha önce ciddi KAH nedeniyle koroner revaskülarizasyon yapılan
hastalar, bilinen konjestif kalp yetersizliği ve ciddi kalp kapak hastalığı
olanlar ve sol ventrikül ejeksiyon fraksiyonu %50’nin altında olanlar çalışma
dışı bırakıldı. Her iki grupta kan örneği alınarak kopeptin düzeyleri
karşılaştırıldı.

Bulgular: KAE’li hastalar içinde izole KAE sıklığı %14.9 idi. Total
koroner anjiyografi serisi arasında ise izole KAE sıklığı %1.34 idi. İzole
KAE’li hastaların %70’i erkek %30’u kadın idi. Ortalama yaş 58 ± 9.2 idi.
Kontrol ve hasta grubu arasında KAH risk faktörleri olan sigara, diyabet ve
hipertansiyon sıklığı açısından belirgin farklılık yoktu ancak hiperlipidemi
izole KAE’li hastalarda daha fazlaydı. Markis sınıflamasına göre KAE’li
hastaların, %4.3’ü tip I, %17.4’ü tip II, %32.6’sı tip III ve %45.6’sı tip IV
olarak saptandı. Koroner arterleri normal saptanan hastalarda kopeptin düzeyi
7.8 ± 0.9 pmol/L iken izole KAE’li hastalarda bu değer 9.7 ± 1.6 pmol/L olarak
saptandı (p< 0.028).

Sonuç: İzole KAE’sinde kopeptin
düzeyi artmıştır. Çalışmamızın sonuçlarının kopeptin düzeylerinin artmış olduğu
izole KAE’li hastaların uzun dönem takip edildiği randomize çalışmalar ile
desteklenmesi gerekmektedir.

Keywords

İzole koroner ektazi, kopeptin

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