Galectin-3 in Middle-Aged Patients with First Episode of Non-valvular Atrial Fibrillation: a Speckle-tracking Study

Year 2017, Volume: 20 Issue: 3, 224 - 229, 03.12.2017

Alev Kılıçgedik Süleyman Çağan Efe Ahmet Seyfettin Gürbüz Emrah Acar Mehmet Fatih Yılmaz Fatih Yılmaz Ali Yaman Gökhan Kahveci İbrahim Akın İzgi Cevat Kırma

Abstract

Introduction: Recent
studies have shown a significant association between left atrial (LA) global
longitudinal strain (GLS) and the progression of atrial fibrillation (AF) with
significantly decreased LA GLS in patients with paroxysmal AF. Significantly
higher levels of serum galectin-3 have also been found in patients with non-valvular
AF. This study aimed to examine the relationship of the early stage of atrial
fibrosis and reduced atrial deformation with serum galectin-3 concentration in
middle-aged patients with a first episode of non-valvular AF.

Patients and Methods:
This
study prospectively enrolled 34 patients who were admitted to our emergency
department and required either a medical or electrical cardioversion due to the
first episode of AF, without any structural or coronary heart disease and with
normal LA size. Additionally, 31 control subjects were also enrolled. The
diameter, volume, and mechanical function of LA, including strain (S) and
strain rate (SR), and serum galectin-3 levels were measured.

Results: The
average age was 48.5 ± 10.4 years. Galectin-3 values were not significantly
different between the AF and control groups (r= 0.42; p= 0.51) and were found
to correlate inversely with peak negative SR on apical four chamber (r= −0.31,
p= 0.02) and two chamber (r= −0.25, p= 0.04) views. In comparison to the control
group, the AF group had significantly lower values of peak systolic S on four
chamber view (p= 0.037), peak late diastolic S (p= 0.04), peak positive SR on
apical four-chamber view (p= 0.04), and peak late negative SR on apical four
chamber (p= 0.03) and two-chamber (p= 0.02) views.

Conclusion: Middle-aged patients with
the first episode of AF and normal LA sizes had reduced LA reservoir and active
atrial functions. Although beginning signs of LA functional remodeling were
shown on S and SR imaging, these were not completely reflected by serum
galectin-3 levels.

Keywords

Atrial fibrillation, strain, strain rate, galectin-3

İlk Atak Non-valvular Atrial Fibrilasyonlu Orta Yaşlı Hastalarda Galectin-3

Abstract

Giriş: Biz bu çalışmada ilk atak non-valvular atriyal fibrilasyon (AF)’lu orta
yaşlı hasta grubunda serum galectin konsantrasyonu ile AF erken evresi
arasındaki ilişkiyi araştırdık.

Hastalar ve
Yöntem: Bu çalışmaya acil servisimize ilk atak AF ile başvuran,
medikal ya da elektriki kardiyoversiyon yapılmış, yapısal ya da koroner kalp
hastalığı olmayan normal LA boyuta sahip 34 hasta ve 31 kontrol hastası
prospektif olarak dahil edildi. Ekokardiyografik bulgular kayıt altına alındı
ve serum galectin düzeyleri ekokardiyografi öncesi alınan kan örneklerinden
ölçüldü.

Bulgular: Hastaların ortalama yaşı 48.5 ± 10.4 yıldı. Galectin değerleri arasında AF
ve kontrol grubu arasında anlamlı fark saptanmadı (r= 0.42 ; p= 0.51) ve apikal
dört boşluk (r= -0.31, p= 0.02) ve iki boşluk görüntüden (r= -0.25 , p= 0.04)
pik negatif SR ile negatif korele bulundu. Kontrol grubu ile
karşılaştırıldığında, AF grubunda dört boşluk görüntüden pik sistolik strain
(p= 0.037), pik geç diastolik strain (p= 0.04), pik positif SR (p= 0.04) ve pik
geç negatif SR apikal dört (p= 0.03) ve iki boşluk (p= 0.02) görüntüden
değerleri anlamlı olarak daha düşük olarak bulunmuştur.

Sonuç: İlk atak AF’li orta yaşlı
ve normal LA boyutuna sahip hastalarda LA rezervuar ve aktif atriyal
fonksiyonlar azalmıştır. Strain ve SR görüntüleme ile gösterilmiş LA
fonksiyonel remodeling belirtileri başlamış olmasına rağmen bu durum serum
galectin düzeyleri ile tam olarak gösterilememiştir.

Keywords

Atriyal fibrilasyon, strain, strain rate, galectin

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