Relation Between Glycosylated Hemoglobin (Hemoglobin A1c) and Aortic Stiffness in Patients with Type 2 Diabetes

Year 2017, Volume: 20 Issue: 2, 137 - 142, 01.08.2017

Taner Şen , Erkan Kahraman Saadet Güven Serkan Topaloğlu Şule Korkmaz

Abstract

Introduction: Type 2 diabetes mellitus (DM) is a major risk factor for cardiovascular
diseases and is responsible for the increase in cardiovascular mortality.
Chronic hyperglycemia is related to accelerated atherosclerosis. In this study,
we tried to demonstrate the relation between glycosylated hemoglobin (HbA1c)
level, which is a marker of long-standing hyperglycemia, and aortic stiffness,
which is a marker of cardiovascular disease.

Patients
and Methods: In total, 100 patients with
type 2 DM were included in this study. Patients were divided into three groups
according to the HbA1c level (group 1 HbA1c ≤ 6, group 2 HbA1c between 6 and 7,
and group 3 HbA1c ≥ 7).

Results: Significant correlation was found between aortic distensibility and
HbA1c level (r= 0.283, p= 0.004). Moreover, aortic distensibility was also
correlated with the duration of DM (r= −0.172, p= 0.05) and age (r= -0.27, p=
0.006). Significant correlation was determined between aortic strain and
fasting blood glucose level, HbA1c level, and the duration of DM (r= −0.265, p=
0.008; r= 0.279, p= 0.005; and r= −0.14, p= 0.03, respectively).

Conclusion:
In this study, we showed that aortic stiffness was increased in patients with
type 2 DM who have high blood fasting glucose and HbA1c levels. Our study also
showed that the duration of DM was related to aortic stiffness.
Echocardiographic non-invasive evaluation of aortic stiffness may be helpful in
the estimation of cardiovascular risk in patients with DM.

Keywords

Aortic stiffness, diabetes mellitus

Tip 2 Diabetes Mellituslu Hastalarda Glikolize Hemoglobin (Hemoglobin A1c) ile Aortik Sertlik Arasındaki İlişki

Abstract

Giriş: Tip 2 diabetes mellitus (DM) kardiyovasküler hastalıklar için major risk
faktörüdür ve DM’li hastalar artmış kardiyovasküler mortalite ve morbiditeye
sahiplerdir. Kronik hiperglisemi ile ilişkili olan birçok mekanizma bu
hızlanmış aterosklerozdan sorumlu tutulmaktadır. Bu çalışmada amaç DM’li
hastalarda uzun dönem glisemik kontrolün belirteci olan HbA1c seviyesi ile
kardiyovasküler hastalıkların belirteci olan aortik sertlik arasındaki ilişkiyi
saptamaktır.

Hastalar
ve Yöntem: Çalışmamıza kliniğimize başvuran Tip 2 DM’li 100
hasta alındı. Hastalar HbA1c değerlerine göre üç gruba ayrıldı.

Bulgular: Gruplar arasında açlık kan şekerleri, DM süresi ve oral antidiyabetik ya
da insülin kullanımında istatistiksel olarak anlamlı şekilde farklı bulundu.
Aortik esneyebilirlik ve HbA1c düzeyi arasında önemli ilişki bulundu (r= 0.283;
p= 0.004). Bunun yanı sıra, DM süresi (r= -0.172; p= 0.05) açlık kan şekeri
(r=0.292; p= 0.003) ve hasta yaşı ile (r= -0.27; p= 0.006) aortik
esneyebilirlik arasında da istatistiksel anlama ulaşan korelasyon tespit
edildi. Bunun yanında aortik gerilim ile açlık kan şekeri, HbA1c, DM süresi
arasında (sırasıyla; r= -0.265; p= 0.008, r= 0.279; p= 0.005 ve r= -0.14; p=
0.03) anlamlı korelasyon bulundu.

Sonuç:
Bu çalışmada, yüksek açlık kan şekeri ve HbA1c düzeyine sahip tip 2 diyabet
hastalarında aortik sertliğin arttığını gösterdik. Aynı zamanda çalışmamız
diyabetin süresi ile aortik sertliğin ilişkili olduğunu göstermiştir. Ekokardiyografiyle
noninvaziv yöntem olarak ölçülen aortik elastisite parametreleri hastalığın erken
döneminde kardiyovasküler riski tahmin etmede ve önlemede faydalı olabilir.

Keywords

Aortik sertlik, diabetes mellitus

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