Monosit Sayısı/HDL Oranı ile Koroner Arter Hastalığının Ciddiyeti ve Yaygınlığı Arasındaki İlişki

Year 2017, Volume: 20 Issue: 1, 30 - 35, 03.04.2017

Emrullah Kızıltunç Yakup Alsancak Burak Sezenöz Selçuk Özkan Serkan Sivri , Aybüke Demir Alsancak Gülten Taçoy

Abstract

Giriş: Kan dolaşımında bulunan monosit sayısı yeni aterosklerotik plak oluşumunda
öngörücüdür. Bununla birlikte yüksek dansiteli lipoprotein kolesterol (HDL)
düzeyleri ile ateroskleroz arasında güçlü bir negatif ilişki vardır. Bu
çalışmada, monosit sayısı/HDL oranıyla koroner arter hastalığı ciddiyeti
arasındaki ilişkiyi değerlendirmeyi amaçladık.

Hastalar ve
Yöntem: Koroner anjiyografi yapılan toplam 760 hasta çalışmaya
dahil edildi. Koroner ateroskleroz ciddiyeti Gensini skorlama sistemi
kullanılarak değerlendirildi ve hastalar Gensini skorlarına göre yüksek (>
20) ve düşük (< 20) olarak iki gruba ayrıldı. Bazal karakteristik özellikler
ve laboratuvar parametreleri kaydedilerek yüksek ve düşük Gensini skoru olan
hastalar arasında karşılaştırıldı.

Bulgular: Hipertansiyon, diabetes mellitus, hiperlipidemi, ileri yaş ve sigara
içiciliği yüksek Gensini skoru olan hastalarda daha fazlaydı. Açlık kan şekeri,
kreatinin düzeyleri ve monosit/HDL oranı düşük Gensini skoru olan hastalarda
yüksek Gensini skoru olanlara kıyasla daha düşüktü. Lojistik regresyon
analizinde ileri yaş, açlık kan şekeri, hiperlipidemi, aile öyküsü ve erkek
cinsiyetin yüksek Gensini skoru için bağımsız parametreler olduğu gözlendi.
Monosit/HDL oranının, Gensini skoruyla korele olduğu (p< 0.001) ancak bu
korelasyonun çok zayıf olduğu tespit edildi (Spearman’s Rho: 0.159).

Sonuç: Monosit/HDL oranı ile Gensini skoruyla elde
edilen ateroskleroz yaygınlığı arasında zayıf da olsa bir ilişki izlenmiştir.
Ancak Monosit/HDL oranı ve aterosklerotik kalp hastalığı arasındaki ilişkiyi
belirlemek için daha fazla klinik çalışmaya ihtiyaç vardır.

Keywords

Monosit sayısı, yüksek dansiteli lipoprotein kolesterol, ateroskleroz, koroner arter hastalığı, Gensini skoru

Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease

Abstract

Introduction:
Circulating
monocyte count is predictive of new atherosclerotic plaque development. In
addition, there is a strong inverse relationship between high-density
lipoprotein (HDL) cholesterol and atherosclerosis. We aimed to investigate the
relationship between the monocyte/HDL cholesterol ratio and severity of
coronary artery disease.

Patients
and Methods: A total of 760 patients who underwent coronary
angiography were included in the study. The severity of coronary
atherosclerosis was calculated by the Gensini score, and the patients were
grouped as having low (< 20) and high (> 20) Gensini scores. Baseline
characteristics and laboratory parameters were recorded and compared between
patients with low and high Gensini scores.

Results: Hypertension,
diabetes mellitus, hyperlipidaemia, advanced age and smoking were more common
in patients with a high Gensini score. Fasting blood glucose levels, creatinine
levels and monocyte/HDL cholesterol ratio were significantly lower in patients
with a low Gensini score than in those with a high Gensini score. Logistic
regression analysis revealed that older age, fasting blood glucose levels,
hyperlipidaemia, family history of coronary artery disease and male gender were
independent predictors of a high Gensini score. We observed a correlation
between the monocyte/HDL cholesterol ratio and Gensini score (p< 0.001).
However, this correlation was weak (Spearman’s rho = 0.159).

Conclusion: We observed a positive but weak correlation
between the monocyte/HDL cholesterol; ratio and increased coronary
atherosclerotic burden, as calculated by Gensini scoring. Further studies are
required to demonstrate the relationship between the monocyte/HDL cholesterol
ratio and atherosclerotic cardiovascular disease.

Keywords

Monocyte count, high-density lipoprotein cholesterol, atherosclerosis, coronary artery disease, Gensini score

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