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Biyoprotez Aort Kapak Replasmanı Sonrası Görülebilen Trombositopeni ve İlişkili Komplikasyonların Değerlendirilmesi

Year 2017, Volume: 20 Issue: 1, 47 - 52, 03.04.2017

Abstract

Giriş: Biyoprotez aort kapak replasmanı yapılan hastalarda görülebilen
trombositopeninin (TCP) postoperatif komplikasyonlar ile ilişkili olup
olmadığını belirlemeyi amaçladık.



Hastalar ve
Yöntem:
Aort darlığı nedeniyle biyoprotez aort kapak replasmanı
yapılan 39 ardışık hastanın klinik kayıtları incelendi. Hastalar operasyondan
sonraki 7 güne kadar trombositopeni görülen ve görülmeyenler olarak iki gruba
ayrıldı. (TCP+; 9 hasta ve TCP-; 30 hasta) Trombositopeni, 50 x 109/L’den
az trombosit sayısı olarak tanımlandı.



Bulgular: İki grup bazal klinik özellikleri ve operasyonel değişkenler açısından
benzerdi. Stentsiz biyoprotez kapak 16 hastada kullanıldı (41.02%). Sorin Pericarbon
Freedom kullanımı TCP (+) grubunda anlamlı olarak daha yaygındı. Drenaj
tüplerinin çekilme süresi, yoğun bakım ünitesi (YBÜ)’nde kalış süresi ve akut
böbrek yetmezliği gibi postoperatif komplikasyonlar, TCP (+) grupta anlamlı
olarak yüksek bulundu. Otuz günlük mortalite 3 (%7.7) idi ve mortalite
açısından iki grup arasındaki fark istatistiksel olarak anlamlı değildi.



Sonuç: Biyoprotez aort kapak replasmanı sonrası
görülebilen trombositopeni tablosu, hastalar için önemli bir tehdit ile
ilişkili olabilmektedir. Bu fenomenin oluş mekanizması tam olarak
aydınlatılamamış olmakla beraber yüksek sayılı araştırmalara tabi tutulması
gerekmektedir.

References

  • 1. Kuehnel RU, Pohl A, Puchner R, Wendt MO, Hartrumpf M, Pohl M, et al. Opening and closure characteristics of different types of stented biological valves. Thorac Cardiovasc Surg 2006;54:85-90.
  • 2. Gulbins H, Reichenspurner H. Which patients benefit from stentless aortic valve replacement? Ann Thorac Surg 2009;88:2061-8.
  • 3. Nyawo B, Graham R, Hunter S. Aortic valve replacement with the Sorin Pericarbon Freedom stentless valve: five-year follow up. J Heart Valve Dis 2007;16:42-8.
  • 4. Kunadian B, Vijayalakshmi K, Thornley AR, de Belder MA, Hunter S, Kendall S, et al. Meta-analysis of valve hemodynamics and left ventricular mass regression for stentless versus stented aortic valves. Ann Thorac Surg 2007;84:73-8.
  • 5. Perez de Arenaza D, Lees B, Flather M, Nugara F, Husebye T, Jasinski M, et al; ASSERT (Aortic Stentless versus Stented valve assessed by Echocardiography Randomized Trial) Investigators. Randomized comparison of stentless versus stented valves for aortic stenosis: effects on left ventricular mass. Circulation 2005;112:2696-702.
  • 6. Doss M, Martens S, Wood JP, Aybek T, Kleine P, Wimmer Greinecker G, et al. Performance of stentless versus stented aortic valve bioprosthesis in the elderly patient: a prospective randomized trial. Eur J Cardiothorac Surg 2003;23:299-304.
  • 7. Westaby S. Implant technique for the Sorin stentless pericardial valve. Oper Tech Thorac Cardiovasc Surg 2001;6:101-5.
  • 8. Aymard T, Eckstein F, Englberger L, Stalder M, Kadner, A, Carrel, T. The Sorin Freedom SOLO stentless aortic valve: technique of implantation and operative results in 109 patients. J Thorac Cardiovasc Surg 2010;139:775-7.
  • 9. Yerebakan C, Kaminski A, Westphal B, Kundt G, Ugurlucan M, Steinhoff G, et al. Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis. Interact Cardiovasc Thorac Surg 2008;7:616-20.
  • 10. Piccardo A, Rusinaru D, Petitprez B, Marticho P, Vaida I, Tribouilloy C, et al. Thrombocytopenia after aortic valve replacement with freedom solo bioprosthesis: a propensity study. Ann Thorac Surg 2010;89:1425-30.
  • 11. Kolseth SM, Nordhaug D, Stenseth R, Wahba A. Initial experience with the Freedom Solo® stentless aortic valve in a low volume centre. Scand Cardiovasc J 2010;44:301-6.
  • 12. Reents W, Babin-Ebell J, Zacher M, Diegeler A. Thrombocytopenia after aortic valve replacement with the Sorin Freedom Solo prosthesis. J Heart Valve Dis 2011;20:313-8.
  • 13. Gersak B, Gartner U, Antonic M. Thrombocytopenia following implantation of the stentless biological Sorin Freedom SOLO valve. J Heart Valve Dis 2011;20:401-6.
  • 14. Hirnle T, Juszczyk G, Tycińska A, Stankiewicz A, Zak G, Lewczuk A, et al. Thrombocytopenia and perioperative complications after stentless Freedom Solo valve implantation. Kardiol Pol 2012;71:334-40.
  • 15. Repossini A, Bloch D, Muneretto C, Piccoli P, Bisleri G,Beholz, S. Platelet reduction after stentless pericardial aortic valve replacement. Interact Cardiovasc Thorac Surg 2012;14:434-8.
  • 16. Ravenni G, Celiento M, Ferrari G, Milano A, Scioti G, Pratali S, et al. Reduction in platelet count after aortic valve replacement: comparison of three bioprostheses. J Heart Valve Dis 2012;21:655-61.
  • 17. Altintas G, Diken AI, Hanedan O, Yurdakok O, Ozyalcin S, Kucuker SA, et al. The Sorin Freedom SOLO Stentless Tissue Valve: Early Outcomes after Aortic Valve Replacement. Tex Heart Inst J 2013;40:50-5.
  • 18. van Straten AH, Soliman Hamad MA, Berreklouw E, ter Woorst, JF, Martens EJ, Erwin SH, et al. Thrombocytopenia after aortic valve replacement: comparison between mechanical and biological valves. J Heart Valve Dis 2010;19:394-9.
  • 19. Repossini A, Muneretto C, Martini G. Thrombocytopenia after Sorin Freedom Solo valve implant. Ann Thorac Surg 2011;91:1307.
  • 20. Alfirevic A, Xu M, Johnston D, Figueroa P, Koch CG. Transfusion increases the risk for vasoplegia after cardiac operations. Ann Thorac Surg 2011;92:812-9.
  • 21. Fitzmaurice GJ, Parissis HD. Platelet transfusion associated with acute lung injury after coronary artery bypass grafting. Ann Thorac Surg 2011;91:1977-9.
  • 22. Beholz S, Claus B, Dushe S, Konertz, W. Operative technique and early hemodynamic results with the Freedom Solo valve. J Heart Valve Dis 2006;15:429-32.
  • 23. Horst M, Easo J, Hölzl PP, Eichstaedt HC, Kronberg K, Nordmeyer P, et al. The Freedom SOLO Valve: Mid-Term Clinical Results with a Stentless Pericardial Valve for Aortic Valve Replacement. J Heart Valve Dis 2011;20:704-10.
  • 24. D’Onofrio A, Auriemma S, Magagna P, Favaro A, Cannarella A, Piccin C, et al. Aortic valve replacement with the Sorin Pericarbon Freedom stentless prosthesis: 7 years’ experience in 130 patients. J Thorac Cardiovasc Surg 2007;134:491-5.

Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation

Year 2017, Volume: 20 Issue: 1, 47 - 52, 03.04.2017

Abstract

Introduction:
We
aimed to determine whether thrombocytopaenia (TCP) is associated with
postoperative complications in patients undergoing bioprosthetic aortic valve
replacement.



Patients
and Methods:
Clinical records of 39 consecutive patients undergoing
bioprosthetic aortic valve replacement for aortic stenosis were reviewed.
Patients were divided into 2 groups based on whether they had TCP or not within
7 days after the operation [TCP (+), 9 patients and TCP (-), 30 patients]. TCP
was defined as a platelet count less than 50 × 109/L.



Results: Both the
groups were similar with regard to baseline clinical characteristics and
operative variables. Stentless bioprosthesis was used in 16 patients (41.02%).
The use of Sorin Pericarbon Freedom was significantly more common in the TCP
(+) group. Postoperative complications such as the removal time of the drainage
tube, intensive care unit (ICU) stay and acute renal failure were significantly
higher in the TCP (+) group. Overall, 30-day mortality occurred in 3 (7.7%)
patients, and the difference between the groups was not statistically
significant.



Conclusion: Postoperative TCP may be associated with a substantial
threat for the postoperative status of patients undergoing bioprosthetic valve
replacement. The issue is still subject to further research until the exact
mechanism underlying its occurrence is elucidated.

References

  • 1. Kuehnel RU, Pohl A, Puchner R, Wendt MO, Hartrumpf M, Pohl M, et al. Opening and closure characteristics of different types of stented biological valves. Thorac Cardiovasc Surg 2006;54:85-90.
  • 2. Gulbins H, Reichenspurner H. Which patients benefit from stentless aortic valve replacement? Ann Thorac Surg 2009;88:2061-8.
  • 3. Nyawo B, Graham R, Hunter S. Aortic valve replacement with the Sorin Pericarbon Freedom stentless valve: five-year follow up. J Heart Valve Dis 2007;16:42-8.
  • 4. Kunadian B, Vijayalakshmi K, Thornley AR, de Belder MA, Hunter S, Kendall S, et al. Meta-analysis of valve hemodynamics and left ventricular mass regression for stentless versus stented aortic valves. Ann Thorac Surg 2007;84:73-8.
  • 5. Perez de Arenaza D, Lees B, Flather M, Nugara F, Husebye T, Jasinski M, et al; ASSERT (Aortic Stentless versus Stented valve assessed by Echocardiography Randomized Trial) Investigators. Randomized comparison of stentless versus stented valves for aortic stenosis: effects on left ventricular mass. Circulation 2005;112:2696-702.
  • 6. Doss M, Martens S, Wood JP, Aybek T, Kleine P, Wimmer Greinecker G, et al. Performance of stentless versus stented aortic valve bioprosthesis in the elderly patient: a prospective randomized trial. Eur J Cardiothorac Surg 2003;23:299-304.
  • 7. Westaby S. Implant technique for the Sorin stentless pericardial valve. Oper Tech Thorac Cardiovasc Surg 2001;6:101-5.
  • 8. Aymard T, Eckstein F, Englberger L, Stalder M, Kadner, A, Carrel, T. The Sorin Freedom SOLO stentless aortic valve: technique of implantation and operative results in 109 patients. J Thorac Cardiovasc Surg 2010;139:775-7.
  • 9. Yerebakan C, Kaminski A, Westphal B, Kundt G, Ugurlucan M, Steinhoff G, et al. Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis. Interact Cardiovasc Thorac Surg 2008;7:616-20.
  • 10. Piccardo A, Rusinaru D, Petitprez B, Marticho P, Vaida I, Tribouilloy C, et al. Thrombocytopenia after aortic valve replacement with freedom solo bioprosthesis: a propensity study. Ann Thorac Surg 2010;89:1425-30.
  • 11. Kolseth SM, Nordhaug D, Stenseth R, Wahba A. Initial experience with the Freedom Solo® stentless aortic valve in a low volume centre. Scand Cardiovasc J 2010;44:301-6.
  • 12. Reents W, Babin-Ebell J, Zacher M, Diegeler A. Thrombocytopenia after aortic valve replacement with the Sorin Freedom Solo prosthesis. J Heart Valve Dis 2011;20:313-8.
  • 13. Gersak B, Gartner U, Antonic M. Thrombocytopenia following implantation of the stentless biological Sorin Freedom SOLO valve. J Heart Valve Dis 2011;20:401-6.
  • 14. Hirnle T, Juszczyk G, Tycińska A, Stankiewicz A, Zak G, Lewczuk A, et al. Thrombocytopenia and perioperative complications after stentless Freedom Solo valve implantation. Kardiol Pol 2012;71:334-40.
  • 15. Repossini A, Bloch D, Muneretto C, Piccoli P, Bisleri G,Beholz, S. Platelet reduction after stentless pericardial aortic valve replacement. Interact Cardiovasc Thorac Surg 2012;14:434-8.
  • 16. Ravenni G, Celiento M, Ferrari G, Milano A, Scioti G, Pratali S, et al. Reduction in platelet count after aortic valve replacement: comparison of three bioprostheses. J Heart Valve Dis 2012;21:655-61.
  • 17. Altintas G, Diken AI, Hanedan O, Yurdakok O, Ozyalcin S, Kucuker SA, et al. The Sorin Freedom SOLO Stentless Tissue Valve: Early Outcomes after Aortic Valve Replacement. Tex Heart Inst J 2013;40:50-5.
  • 18. van Straten AH, Soliman Hamad MA, Berreklouw E, ter Woorst, JF, Martens EJ, Erwin SH, et al. Thrombocytopenia after aortic valve replacement: comparison between mechanical and biological valves. J Heart Valve Dis 2010;19:394-9.
  • 19. Repossini A, Muneretto C, Martini G. Thrombocytopenia after Sorin Freedom Solo valve implant. Ann Thorac Surg 2011;91:1307.
  • 20. Alfirevic A, Xu M, Johnston D, Figueroa P, Koch CG. Transfusion increases the risk for vasoplegia after cardiac operations. Ann Thorac Surg 2011;92:812-9.
  • 21. Fitzmaurice GJ, Parissis HD. Platelet transfusion associated with acute lung injury after coronary artery bypass grafting. Ann Thorac Surg 2011;91:1977-9.
  • 22. Beholz S, Claus B, Dushe S, Konertz, W. Operative technique and early hemodynamic results with the Freedom Solo valve. J Heart Valve Dis 2006;15:429-32.
  • 23. Horst M, Easo J, Hölzl PP, Eichstaedt HC, Kronberg K, Nordmeyer P, et al. The Freedom SOLO Valve: Mid-Term Clinical Results with a Stentless Pericardial Valve for Aortic Valve Replacement. J Heart Valve Dis 2011;20:704-10.
  • 24. D’Onofrio A, Auriemma S, Magagna P, Favaro A, Cannarella A, Piccin C, et al. Aortic valve replacement with the Sorin Pericarbon Freedom stentless prosthesis: 7 years’ experience in 130 patients. J Thorac Cardiovasc Surg 2007;134:491-5.
There are 24 citations in total.

Details

Primary Language English
Journal Section Original Investigations
Authors

Sabit Sarıkaya This is me

Eray Aksoy This is me

Mehmet Dedemoğlu This is me

Davut Çekmecelioğlu This is me

Özge Altaş This is me

Yücel Özen This is me

Kaan Kırali This is me

Publication Date April 3, 2017
Published in Issue Year 2017 Volume: 20 Issue: 1

Cite

Vancouver Sarıkaya S, Aksoy E, Dedemoğlu M, Çekmecelioğlu D, Altaş Ö, Özen Y, Kırali K. Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation. Koşuyolu Heart Journal. 2017;20(1):47-52.