Aterosklerozun Erken Dönemi ile Benign Prostat Hiperplazi Arasındaki İlişkinin Karotis İntima Media Kalınlığı Kullanılarak Değerlendirilmesi

Year 2016, Volume: 19 Issue: 3, 179 - 183, 01.12.2016

Turhan Turan , Ahmet Çağrı Aykan Tayyar Gökdeniz Hasan Rıza Aydın Ali Rıza Akyüz Hasan Turgut Yılmaz Ofluoğlu İlker Gül Selim Kul Alimdar Şimşek Ali Tüten Ayça Ata Korkmaz

Abstract

Giriş:  Bening prostat
hiperplazisi (BPH), yaşlı erkeklerde en sık görülen hastalıktır. BPH’nin
ateroskleroz ile ilişkisi bilinmesine karşın; subklinik ateroskleroz ile
ilişkisi henüz değerlendirilmemiştir. Bizim çalışmamızın amacı, bu ilişkinin
karotis intima media kalınlığı (KİMK) kullanılarak araştırılmasıydı.

Hastalar
ve Yöntem: Çalışmaya, 50-65 yaş arasında
50 BPH hastası ve BPH’si olmayan 50 erkek hasta kontrol deneği dahil edildi.
Alt ürüner sistem semptomları (AÜSS)’nın değerlendirilmesinde kullanılan,
uluslararası prostat semptom skoruna (IPSS) göre,  hastalar hafif-orta AÜSS (IPSS < 20, n= 33
hasta) ve ciddi AÜSS (IPSS ≥ 20, n= 17 hasta) gruplarına ayrıldı. KİMK ve diğer
parametreler açısından gruplar karşılaştırıldı.

Bulgular: Kontrol grubuyla karşılaştırıldığında, BPH grubunda KİMK
önemli düzeyde yüksekti (sırasıyla, 0.73 ± 0.2 vs. 0.97 ± 0.3, p< 0.001).
Ayrıca, yalnızca hastaları kapsayan alt grup analizinde, hafif-orta AÜSS
grubuna göre ciddi AÜSS grubunda da CIMT önemli düzeyde yüksekti (sırasıyla,
0.84 ± 0.2 vs. 1.22 ± 0.3,     p<
0.001). KİMK ve IPSS arasında önemli derecede pozitif korelasyon vardı.
Multivariate regresyon analizinde KİMK ve HDL kolesterol BPH’nin bağımsız
göstergeleri olarak bulundu.

Sonuç: Subklinik ateroskleroz
ve BPH aynı etiopatogenik faktörleri paylaşıyor olabilir. Bu nedenle benzer yaş
grubundaki erkeklerde, BPH ve alt üriner sistem semptomları, aterosklerotik
yükün göstergesi olabilir.

Keywords

Benign prostat hiperplazisi, subclinical atherosclerosis, carotid intima-media thickness

Assessment of Relationship Between Subclinical Atherosclerosis and Benign Prostate Hyperplasia Using Epicardial Fat Thickness and Carotid Intima-Media Thickness

Abstract

Introduction:
Benign prostatic hyperplasia (BPH) is the most common disorder in elderly men.
Although the relationship between atherosclerosis and BPH is known, the
association between subclinical atherosclerosis and BPH has not yet been
investigated. The aim of our study was to assess this relationship using
carotid intima-media thickness (CIMT).

Patients
and Methods: Fifty patients with BPH and 50 control
subjects without BPH of ages 50-65 years were enrolled. According to the
international prostate symptom score (IPSS), which is used for the evaluation
of LUTS, patients were divided into mild-moderate (IPSS< 20 point, n= 33
patients) and severe groups (IPSS ≥ 20 point, n= 17 patients). CIMT was
evaluated using ultrasonography. The relationship between CIMT and other parameters
were analysed.

Results:
CIMT was significantly higher in BPH group (p=
0.02). In addition, it was significantly higher in severe LUTS group in
subgroup analyses, which included only patients (1.22 ± 0.3 vs. 0.84 ± 0.2,
p< 0.001). There was a positive correlation between CIMT and IPSS (r= 0.745,
p< 0.001). CIMT and HDL cholesterol were found to be independent predictors
of BPH in multivariate analysis.

Conclusion:
Subclinical atherosclerosis and BPH may share
common aetiopathogenic factors. Therefore, BPH and lower urinary tract symptoms
may be indicators of atherosclerotic burden in men of the same age group.

Keywords

Benign prostatic hyperplasia, subclinical atherosclerosis, carotid intima-media thickness

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