Monositin HDL Kolesterole Oranının Kardiyak Sendrom X ve Sistemik İnflamasyon ile İlişkisi

Year 2016, Volume: 19 Issue: 2, 97 - 102, 01.08.2016

Elnur Alizade , Anıl Avcı Ahmet Güner Mehmet Mustafa Tabakcı Regayip Zehir Ahmet Güler Servet İzci Selçuk Pala

Abstract

Giriş:
Bu çalışmanın amacı, kardiyak sendrom X (KSX)
hastalarında monositin HDL kolesterole oranı (MHO)’nı ve kolay kullanılabilir
inflamatuvar göstericileri araştırmaktır.

Hastalar
ve Yöntem: Çalışmaya 50’si KSX ve 50’si
normal koroner arterlere sahip toplam 100 hasta dahil edilmiştir.

Bulgular:
Total beyaz küre sayısı, nötrofil sayısı, monosit
sayısı, lenfosit sayısı, nötrofil/lenfosit oranı, C-reaktif protein, hsCRP ve
MHO KSX grubunda artmıştır (p< 0.05), ancak HDL kolesterol CSX hastalarında
kontrol grubuna göre azalmıştır (p< 0.05). Korelasyon analizinde
MHO’nun  hsCRP (r= 0.375, p< 0.001) ve
CRP (r= 0.403, p< 0.001) ile pozitif yönde korelasyon olduğu
gösterilmiştir.  Multivariate logistic
regresyon analizinde MHO’nun KSX hastalığını göstermede bağımsız bir gösterge
olduğu bulundu [odds ratio: 1.250, 95% confidence interval (CI): 1.240-1.461,
p< 0.001]. Sınır değeri 90.6 alırsak, MHO bu oran ile KSX hastalığının
varlığını %78 duyarlılık ve %70 özgüllükle göstermektedir.

Sonuç: Çalışmamızda MHO KSX hastalarını
göstermede ciddi ve bağımsız bir gösterge olduğu gösterilmiştir.

Keywords

Kardiyak sendrom X, monositin HDL kolesterole oranı, inflamatuvar göstergeler

Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

Abstract

Introduction:
The aim of this study was to investigate an easily
available inflammatory marker and monocyte-to-high-density lipoprotein
cholesterol ratio (MHR) in patients with cardiac syndrome X (CSX).

Patients
and Methods: The study population included 100 patients of
which 50 had CSX (CSX group) and 50 had normal coronary angiograms (control
group).

Results: Total
white blood cell (WBC) count, monocyte count, neutrophil count, NLR,
high-sensitivity C-reactive protein (hs-CRP), C-reactive protein (CRP) and MHR
were higher in the CSX group (p< 0.05), whereas high-density lipoprotein
cholesterol (HDL-C) level was significantly lower in the CSX group as compared
with that in the control group (p< 0.05). In the correlation analysis, MHR
revealed a significantly positive correlation with hs-CRP (r= 0.375, p<
0.001) and CRP (r= 0.403, p< 0.001). In the multivariate logistic regression
analysis, MHR was independently associated with the presence of CSX (odds
ratio: 1.250, 95% confidence interval [CI]: 1.240-1.461, p< 0.001). Using a
cut-off level of 90.6, pre-procedural MHR predicted the presence of slow
coronary flow (SCF) with a sensitivity of 78% and specificity of 70%.

Conclusion: In conclusion, our findings
revealed that higher MHR levels were significantly and independently associated
with the presence of CSX.

Keywords

Cardiac syndrome X, monocyte-to-HDL cholesterol ratio, inflammatory markers

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