Ankaferd® Kanama Durdurucunun Rat Abdominal Aort Kanama Modelinde Kanama Zamanına Etkisi

Year 2016, Volume: 19 Issue: 2, 103 - 107, 01.08.2016

Oruç Alper Onk Mehmet Aksüt Fatih Özçelik Didem Onk Erdim Sertoğlu Hüseyin Serkan Erol Ümit Kahraman Osman Nuri Tuncer Ömer Yiğiner Bilgehan Erkut

Abstract

Giriş:
Topikal hemostatik ajanların birçok cerrahi alanda
kullanımı son yıllarda popularite kazanmıştır. Ankaferd^® kanama
durdurucu (ABS) ajanın ratlarda abdominal aort cerrahisinde kanama zamanını
kısaltıp, kanama miktarını azaltabildiğini belirt          meye amaçladık.

Hastalar
ve Yöntem: Toplam 40 rat random 4 gruba
(her grup n= 10) ayrıldı. Grup 1 ve grup 2’deki ön-tedavi almayan ratlara salin
ve Ankaferd kanama durdurucu ABS emdirilmiş gaz uygulanırken, 5 gün asetil
salisilik asit ve klopidgrel tedavisi alış olan grup 3 ve 4’teki ratlara da
salin ve ABS emdirilmiş gaz uygulandı. İliak bifurkasyonun üzerinde abdominal
aortaya 1 mm’lik bir kesi yapıldı. Ortalama kanama zamanı ve ortalama kanama
miktarı belirlenip karşılaştırıldı.

Bulgular:
Ratların yaş, ağırlık ve laboratuvar sonuçları karşılaştırıldığında
gruplar arası anlamlı farklılık yoktu. ABS emdirilmiş gaz kullanılan hem tedavi
uygulanmış hem de tedavi uygulanmamış gruplarda daha kısa kanama zamanı ve daha
az kanama miktarı tespit edildi. Aradaki fark istatistiksel olarak anlamlı bulundu.

Sonuç: Ankaferd^® kanama
durdurucunun major aort cerrahisi sonrası daha kısa kanama zamanı sağlama ve
operasyon sonrası daha az kan kaybı sağlama potansiyeline sahiptir.

Keywords

Topikal hemostaz, abdominal aort

Haemostatic Effects of Topical Ankaferd Blood Stopper® On Bleeding Time in A Rat Abdominal Aortic Bleeding Model

Abstract

Introduction:
The use of topical haemostatic agents has been
popularised in recent years in many areas of surgery. We aimed to determine
whether Ankaferd blood stopper^® (ABS) can shorten the bleeding time
and decrease the amount of bleeding in a rat abdominal aortic bleeding model.

Patients
and Methods: A total of 40 rats were randomly divided into
four groups (n= 10 in each group). Saline- and ABS-soaked gauzes were applied
to rats that had not received any pre-treatment in Groups 1 and 2, while
saline- and ABS-soaked gauzes were applied to rats that had received
acetylsalicylic acid plus oral clopidrogel for 5 days in Groups 3 and 4. An
incision of about 1 mm was made over the aorta just proximal to the iliac
bifurcation. Mean bleeding time (MBT) and mean bleeding amount (MBA) were
determined and compared.

Results: There
were no significant differences in the age, weight and blood sample laboratory
results of rats. Shorter MBT and less MBA were determined in ABS-soaked groups
and the differences were statistically significant.

Conclusion: Ankaferd blood stopper^®
has the potential to reduce the bleeding time and post-operative blood loss
after a major aortic surgery.

Keywords

Topical haemostasis, abdominal aorta

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