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Kapak Dışı Atriyal Fibrilasyonda Uzun Dönem Mortalite

Year 2015, Volume: 18 Issue: 3, 135 - 138, 01.12.2015

Abstract











Giriş:
Kapak dışı atriyal fibrilasyonu (AF) olan
hastalarda uzun dönemde gerçekleşen tüm sebeplere bağlı ve kardiyovasküler
nedenlere bağlı mortaliteyi belirlemeyi amaçladık.



Hastalar
ve Yöntem:
1995 ile 2010 yılları
arasında kliniğimize başvuran ve kapak dışı AF tanısı konan 352 hasta (153
erkek, 199 kadın; ort. yaş 62; dağılım 34-82) geriye dönük olarak incelendi.
Takip süresi 72-176 ay arasında değişmekteydi (ort. 110 ay).



Bulgular:
Atriyal fibrilasyon etkeni veya ilişkili durumu
olarak hipertansiyon (%51.1), koroner kalp hastalığı (%29.9), kalp yetersizliği
(%48.8), diabetes mellitus (%11.9), pulmoner hipertansiyon (%9.9) saptandı.
İzlem sırasında 72 hastanın (%21) öldüğü belirlendi. Ölümler 30 hastada (%41.7)
kardiyovasküler nedenli, 20 hastada (%27.8) inme kaynaklı, altı hastada (%8.3)
ani ölüm idi; 16 hastada (%22.2) ölümler diğer nedenlere (malignite, kaza,
infeksiyon vb.) bağlandı.



Sonuç: Kapak dışı AF’li  hastalarda uzun dönemde ana ölüm nedeninin
kardiyovasküler kaynaklı olduğu görüldü. 

References

  • 1. Stewart S, Hart CL, Hole DJ, McMurray JJ. Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study. Heart 2001;86:516-21.
  • 2. Heeringa J, van der Kuip DA, Hofman A, Kors JA, van Herpen G, Stricker BH, et al. Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J 2006;27:949-53.
  • 3. Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol 2009;104:1534-9.
  • 4. Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, et al. Outcome parameters for trials in atrial fibrillation: executive summary. Eur Heart J 2007;28:2803-17.
  • 5. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983-8.
  • 6. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002;347:1825-33.
  • 7. Roy D, Talajic M, Dubuc M, Thibault B, Guerra P, Macle L, et al. Atrial fibrillation and congestive heart failure. Curr Opin Cardiol 2009;24:29-34.
  • 8. Levy S, Maarek M, Coumel P, Guize L, Lekieffre J, Medvedowsky JL, et al. Characterization of different subsets of atrial fibrillation in general practice in France: the ALFA study. The College of French Cardiologists. Circulation 1999;99:3028-35.
  • 9. Potpara T, Grujić M, Marinković J, Ostojić M, Vujisić-Tesić B, Polovina M, et al. Relationship between mortality of patients with atrial fibrillation and mortality of general population in Serbia [Article in Serbian]. Srp Arh Celok Lek 2010;138:177-85.
  • 10. Li D, Fareh S, Leung TK, Nattel S. Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 1999;100:87-95.
  • 11. Shinbane JS, Wood MA, Jensen DN, Ellenbogen KA, Fitzpatrick AP, Scheinman MM. Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. J Am Coll Cardiol 1997;29:709-15.
  • 12. Nieuwlaat R, Capucci A, Camm AJ, Olsson SB, Andresen D, Davies DW, et al. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation. Eur Heart J 2005;26:2422-34.
  • 13. Nabauer M, Gerth A, Limbourg T, Schneider S, Oeff M, Kirchhof P, et al. The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management. Europace 2009;11:423-34.
  • 14. Goette A, Bukowska A, Dobrev D, Pfeiffenberger J, Morawietz H, Strugala D, et al. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J 2009;30:1411-20.
  • 15. Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010;31:2369-429.
  • 16. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146: 857-67.
  • 17. Britton M, Gustafsson C. Non-rheumatic atrial fibrillation as a risk factor for stroke. Stroke 1985;16:182-8.
  • 18. Candelise L, Pinardi G, Morabito A. Mortality in acute stroke with atrial fibrillation. The Italian Acute Stroke Study Group. Stroke 1991;22:169-74.
  • 19. Sandercock P, Bamford J, Dennis M, Burn J, Slattery J, Jones L, et al. Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire Community Stroke Project). BMJ 1992;305:1460-5.
  • 20. Sage JI, van Uitert RL. Risk of recurrent stroke in patients with atrial fibrillation and non-valvular heart disease. Stroke 1983;14:537-40.
  • 21. Hornig CR, Dorndorf W. Early outcome and recurrences after cardiogenic brain embolism. Acta Neurol Scand 1993;88:26-31.

Long-Term Mortality of Nonvalvular Atrial Fibrillation

Year 2015, Volume: 18 Issue: 3, 135 - 138, 01.12.2015

Abstract











Introduction:
This study sought to determine long-term all-cause mortality and cardiovascular
mortality in patients with nonvalvular atrial fibrillation (AF).



Patients
and Methods:
The study included 352 patients (153 males,
199 females; mean age 62 years; range 34 to 82 years) who presented to our
clinic between 1995 and 2010 and were diagnosed with nonvalvular AF. The
follow-up ranged from 72 to 176 months (mean 110 months).



Results: The
causes or associated conditions of AF were hypertension (51.1%), coronary heart
disease (29.9%), heart failure (48.8%), diabetes mellitus (11.9%), and
pulmonary hypertension (9.9%). Seventy-two patients (21%) died during the
follow-up period. Cardiovascular death was noted in 30 patients (41.7%). Sudden
death was seen in six patients (8.3%). Death from stroke occurred in 20
patients (27.8%), and 16 patients (22.2%) died of other causes (malignancies,
accidents, infectious causes, etc.).



Conclusion:
The major cause of death was of cardiovascular
origin in patients with nonvalvular AF.



References

  • 1. Stewart S, Hart CL, Hole DJ, McMurray JJ. Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew/Paisley study. Heart 2001;86:516-21.
  • 2. Heeringa J, van der Kuip DA, Hofman A, Kors JA, van Herpen G, Stricker BH, et al. Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J 2006;27:949-53.
  • 3. Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol 2009;104:1534-9.
  • 4. Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, et al. Outcome parameters for trials in atrial fibrillation: executive summary. Eur Heart J 2007;28:2803-17.
  • 5. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983-8.
  • 6. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002;347:1825-33.
  • 7. Roy D, Talajic M, Dubuc M, Thibault B, Guerra P, Macle L, et al. Atrial fibrillation and congestive heart failure. Curr Opin Cardiol 2009;24:29-34.
  • 8. Levy S, Maarek M, Coumel P, Guize L, Lekieffre J, Medvedowsky JL, et al. Characterization of different subsets of atrial fibrillation in general practice in France: the ALFA study. The College of French Cardiologists. Circulation 1999;99:3028-35.
  • 9. Potpara T, Grujić M, Marinković J, Ostojić M, Vujisić-Tesić B, Polovina M, et al. Relationship between mortality of patients with atrial fibrillation and mortality of general population in Serbia [Article in Serbian]. Srp Arh Celok Lek 2010;138:177-85.
  • 10. Li D, Fareh S, Leung TK, Nattel S. Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 1999;100:87-95.
  • 11. Shinbane JS, Wood MA, Jensen DN, Ellenbogen KA, Fitzpatrick AP, Scheinman MM. Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. J Am Coll Cardiol 1997;29:709-15.
  • 12. Nieuwlaat R, Capucci A, Camm AJ, Olsson SB, Andresen D, Davies DW, et al. Atrial fibrillation management: a prospective survey in ESC member countries: the Euro Heart Survey on Atrial Fibrillation. Eur Heart J 2005;26:2422-34.
  • 13. Nabauer M, Gerth A, Limbourg T, Schneider S, Oeff M, Kirchhof P, et al. The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management. Europace 2009;11:423-34.
  • 14. Goette A, Bukowska A, Dobrev D, Pfeiffenberger J, Morawietz H, Strugala D, et al. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J 2009;30:1411-20.
  • 15. Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010;31:2369-429.
  • 16. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007;146: 857-67.
  • 17. Britton M, Gustafsson C. Non-rheumatic atrial fibrillation as a risk factor for stroke. Stroke 1985;16:182-8.
  • 18. Candelise L, Pinardi G, Morabito A. Mortality in acute stroke with atrial fibrillation. The Italian Acute Stroke Study Group. Stroke 1991;22:169-74.
  • 19. Sandercock P, Bamford J, Dennis M, Burn J, Slattery J, Jones L, et al. Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire Community Stroke Project). BMJ 1992;305:1460-5.
  • 20. Sage JI, van Uitert RL. Risk of recurrent stroke in patients with atrial fibrillation and non-valvular heart disease. Stroke 1983;14:537-40.
  • 21. Hornig CR, Dorndorf W. Early outcome and recurrences after cardiogenic brain embolism. Acta Neurol Scand 1993;88:26-31.
There are 21 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Investigations
Authors

Cem Bostan

Okay Abacı This is me

Cüneyt Koçaş This is me

Uğur Coşkun This is me

Ahmet Yıldız This is me

Mustafa Sarı This is me

Zerrin Yiğit This is me

Publication Date December 1, 2015
Published in Issue Year 2015 Volume: 18 Issue: 3

Cite

Vancouver Bostan C, Abacı O, Koçaş C, Coşkun U, Yıldız A, Sarı M, Yiğit Z. Long-Term Mortality of Nonvalvular Atrial Fibrillation. Koşuyolu Heart Journal. 2015;18(3):135-8.