Atriyum Fibrilasyonunun İlaç Tedavisindeki Yenilikler

Year 2015, Volume: 18 Issue: 3, 139 - 145, 01.12.2015

Yusuf Türkmen , Cengizhan Türkoğlu Mustafa Yıldız

Abstract

Atriyum
fibrilasyonu (AF) klinikte en sık görülen aritmi cinsidir. Hastalara getirdiği
sağlık sorunları ve mortalite yanı sıra komplikasyonları ekonomik kayıplara
neden olmaktadır. Sağlık sorunlarının başında serebrovasküler ve
kardiyovasküler hastalıklar gelmektedir. Dolayısıyla AF’li hastaların ritmini yeniden
sinüs ritmine döndürmek ve tromboembolik olaylara karşı etkin koruma sağlamak
oldukça önemlidir. Bu amaçla, günümüzde kullanılmakta olan ritim düzenleyici ve
pıhtı oluşumunu önleyici ilaçlar söz konusu ise de, bunlardan elde edilen
yararlar ve kullanım kolaylığı istendiği düzeyde değildir. Hem antiaritmik
ilaçların yan etkileri hem de antikoagülanların dar terapatik sınırları olması
nedeniyle, AF tedavisinde yeni ilaçlara gereksinim duyulmaktadır. Bu amaçla
birçok ilacın AF üzerindeki etkileri araştırılmaktadır. Bu derlemede AF’nin
ilaç tedavisindeki yenilikler ele alınmıştır.

Keywords

Atriyal fibrilasyon, yeni ilaçlar

Novel Medications in the Treatment of Atrium Fibrillation

Abstract

Atrial
fibrillation (AF) is the most commonly encountered arrhythmia. Besides serious
health problems and mortality incurred by patients, its complitacions bring
about substantial economical losses. Among the most important health-related
consequences are cerebrovascular and cardiovascular diseases. Therefore,
convertion of AF to sinus rhythm and effective prevention from thromboembolic
events are of particular importance. Despite the current availability of many
rhythm control and anticoagulant medications, their efficacy and accessibility
are not at a desired level. Due to adverse effects of antiarrhythmic drugs and
narrow therapeutic range of anticoagulant drugs, there have been an increasing
need for novel medications. There is ongoing research on the effects of many
madications on AF. This paper reviews novel medicaitons in AF treatment.

Keywords

Atrial fibrillation, novel drugs

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