Ortalama Trombosit Hacmi ve Nötrofil Lenfosit Oranı: Preeklampsinin Ciddiyetinin Yeni Belirteçleri

Year 2015, Volume: 18 Issue: 2, 84 - 88, 03.08.2015

Mehmet Ata Akıl , Mehmet Zihni Bilik Halit Acet Senem Yaman Tunç Faruk Ertaş Mesut Aydın Hasan Kaya Yahya İslamoğlu Sait Alan

Abstract

Giriş:
Bu çalışmada, hematolojik parametrelerin ölçümleri
ile preeklamptik kadınlarda hipertansiyon şiddetini tahmin etmenin mümkün olup
olmadığını araştırdık.

Hastalar
ve Yöntem: İki yüz altmış bir
preeklamptik ve 51 normal gebe kadın çalışmaya alındı. Preeklampsi olguları
hafif ve ağır preeklampsi olarak sınıflandırıldı.

Bulgular:
Doğum sonrası sonuçlar karşılaştırıldığında,
preeklamptik kadınların trombosit sayıları düşük, ortalama trombosit hacimleri
ve nötrofil lenfosit oranları yüksekti (sırasıyla; p< 0.001, p< 0.001 ve
p< 0.001). Çoklu lineer regresyon analizinde, ortalama trombosit hacmi ve
nötrofil lenfosit oranı hipertansiyon şiddeti ile bağımsız bir şekilde
korelasyon gösterdi (sırasıyla; β= 0.25, p< 0.001 ve β= 0.31, p< 0.001).

Sonuç: Hem 
ortalama trombosit hacmi hemde nötrofil lenfosit oranı preeklamptik
gebelerde hipertansiyonun şiddetini öngörmede bağımsız birer belirleyici olarak
kullanılabilir.

Keywords

Preeklampsi, ortalama trombosit hacmi, nötrofil lenfosit oranı, hipertansiyon

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Abstract

Introduction:
This study was undertaken to examine the role of
hematological parameters in predicting the severity of hypertension in
pre-eclamptic women.

Patients
and Methods: Two hundred sixty-one pre-eclamptic women and
fifty-one women with normal pregnancy were included in the study. The severity
of preeclampsia was classified as mild or severe.

Results:
Compared to post-delivery period, pre-eclamptic
females had lower platelet count, raised mean platelet volume and raised
neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001,
respectively). Multiple linear regression analysis showed an independent
correlation between the severity of hypertension and mean platelet volume as
well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p<
0.001, respectively).

Conclusion:
Both mean platelet volume and neutrophil lymphocyte
ratio emerged as independent predictors of the severity of hypertension in
preeclampsia.

Keywords

Preeclampsia, mean platelet volume, neutrophil lymphocyte ratio, hypertension

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