Bilinen Kardiyovasküler Hastalığı Olmayan Kimselerde Hiperlipidemi ve Kalp Hızı Değişkenliği Arasındaki İlişkinin Araştırılması

Year 2015, Volume: 18 Issue: 1, 29 - 33, 06.04.2015

Alper Kepez , Zekeriya Doğan Ceyhun Mammadov Altuğ Çinçin Halil Ataş Murat Sünbül Tarık Kıvrak Mumune Topçu Bülent Mutlu Okan Erdoğan

Abstract

Giriş: Literatürde
hiperlipidemi ve kalp hızı değişkenliği (KHD) ilişkisiyle ilgili sınırlı sayıda
veri mevcuttur. Çalışmamızın amacı aşikâr kardiyovasküler veya sistemik
hastalığı olmayan bireylerin kayıtlarını retrospektif olarak inceleyerek KHD ve
hiperlipidemi arasındaki ilişkiyi araştırmaktır.

Hastalar ve Yöntem: Ocak 2012 ve
Mayıs 2013 tarihleri arasında kliniğimizde 24 saatlik Holter tetkiki yapılan
tüm hastaların medikal kayıtları incelendi. Sistemik veya kardiyovasküler
hastalığı olmadığına karar verilen kişilerin verileri analizde kullanıldı.

Bulgular: Toplam 37
kişinin verisi kullanıldı. Yirmi kişinin hiperlipidemik (10 erkek, yaş: 44.5 ±
11.1) olduğu saptanırken 17 kişinin normal lipit profiline sahip olduğu izlendi
(5 erkek, yaş: 33.4 ± 10.6; cinsiyet için p= 0.18 ve yaş için p= 0.004).
Hiperlipidemik hasta grubunda normal lipit profili grubuna göre çoğu KHD
parametresinin anlamlı derecede deprese olduğu izlendi ancak aritmi
prevalansları arasında fark saptanmadı. Lineer regresyon analizinde serum
trigliserid düzeyinin RMSSD, PNN50 ve LF/HF oranı ile bağımsız olarak ilişkili
olduğu görüldü (sıra ile beta= -0.40, p= 0.02; beta= -0.41, p= 0.012 ve beta=
-0.31, p= 0.05).

Sonuç: Retrospektif çalışmamız
sonucunda hiperlipidemisi olan grupta normal lipit profili olan kişilere göre
kalp hızı değişkenliğinin anlamlı derecede deprese olduğu gözlendi.
Gözlemlerimiz sonucunda özellikle hipertrigliseridemisi olan hiperlipidemik
kişilerin daha yüksek kardiyak sempatik aktivite gösterdikleri ve bu durumun
artmış kardiyovasküler morbidite ve mortalite ile ilişkili olabileceği
düşünülebilir.

Keywords

Hiperlipidemi, holter kaydı, kalp hızı, otonom sinir sistemi

Evaluation of Association Between Hyperlipidemia and Heart Rate Variability in Subjects Without Apparent Cardiovascular Disease

Abstract

Introduction: There is limited data in
the literature regarding the association between hyperlipidemia and heart rate
variability (HRV). The aim of the present study is to investigate the
association between HRV and hyperlipidemia by retrospectively evaluating the
recordings of subjects free of any apparent cardiovascular or systemic disease.

Patients and Methods: Medical records of
patients to whom 24 hour-Holter recording was performed in our clinic between
January 2012 and May 2013 were retrospectively examined. Data of subjects who
were determined to be free of any cardiovascular or systemic disease were used
in the analysis.

Results:
Data of 37 subjects were used. There were 20 subjects with hyperlipidemia (10
male, age: 44.5 ± 11.1 years) and 17 subjects with normal lipid profile (5
male, age: 33.4 ± 10.6 years; p= 0.18 for gender and p=0.004 for age). Majority
of HRV parameters were found to be significantly depressed in group with
hyperlipidemia; however, there were no significant difference between groups
regarding prevalence of arrhythmias. Out of components of the lipid profile,
linear regression analysis revealed serum triglyceride level to be
independently associated variable with RMSSD, PNN50 and LF/HF ratio (in
respective order; beta= -0.40, p= 0.02; beta= -0.41, p= 0.012 and beta= -0.31,
p= 0.05).

Conclusion: Subjects
with hyperlipidemia were observed to have significantly depressed HRV compared
to subjects with normal lipid profile in our retrospective study. Based on our
observations, it may be suggested that patients with hyperlipidemia, in
particular with hypertriglyceridemia display higher subtle cardiac sympathetic
activity which may be associated with increased cardiovascular morbidity and
mortality.

Keywords

Hyperlipidemia, holter recording, heart rate, autonomic nervous system

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